Imperial College London
Alternate

Professor David Nutt DM, FRCP, FRCPsych, FSB, FMedSci

Faculty of Medicine, Department of Brain Sciences

The Edmond J Safra Chair in Neuropsychopharmacology
 
 
 
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Contact

 

d.nutt

 
 
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Location

 

Burlington Danes BuildingBurlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Morris:2017:10.1111/adb.12503,
author = {Morris, LS and Baek, K and Tait, R and Elliott, R and Ersche, KD and Flechais, R and McGonigle, J and Murphy, A and Nestor, LJ and Orban, C and Passetti, F and Paterson, LM and Rabiner, I and Reed, L and Smith, D and Suckling, J and Taylor, EM and Bullmore, ET and Lingford-Hughes, AR and Deakin, B and Nutt, DJ and Sahakian, BJ and Robbins, TW and Voon, V and ICCAM, Consortium},
doi = {10.1111/adb.12503},
journal = {Addiction Biology},
pages = {425--436},
title = {Naltrexone ameliorates functional network abnormalities in alcohol-dependent individuals.},
url = {http://dx.doi.org/10.1111/adb.12503},
volume = {23},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Naltrexone, an opioid receptor antagonist, is commonly used as a relapse prevention medication in alcohol and opiate addiction, but its efficacy and the mechanisms underpinning its clinical usefulness are not well characterized. In the current study, we examined the effects of 50-mg naltrexone compared with placebo on neural network changes associated with substance dependence in 21 alcohol and 36 poly-drug-dependent individuals compared with 36 healthy volunteers. Graph theoretic and network-based statistical analysis of resting-state functional magnetic resonance imaging (MRI) data revealed that alcohol-dependent subjects had reduced functional connectivity of a dispersed network compared with both poly-drug-dependent and healthy subjects. Higher local efficiency was observed in both patient groups, indicating clustered and segregated network topology and information processing. Naltrexone normalized heightened local efficiency of the neural network in alcohol-dependent individuals, to the same levels as healthy volunteers. Naltrexone failed to have an effect on the local efficiency in abstinent poly-substance-dependent individuals. Across groups, local efficiency was associated with substance, but no alcohol exposure implicating local efficiency as a potential premorbid risk factor in alcohol use disorders that can be ameliorated by naltrexone. These findings suggest one possible mechanism for the clinical effects of naltrexone, namely, the amelioration of disrupted network topology.
AU  - Morris,LS
AU  - Baek,K
AU  - Tait,R
AU  - Elliott,R
AU  - Ersche,KD
AU  - Flechais,R
AU  - McGonigle,J
AU  - Murphy,A
AU  - Nestor,LJ
AU  - Orban,C
AU  - Passetti,F
AU  - Paterson,LM
AU  - Rabiner,I
AU  - Reed,L
AU  - Smith,D
AU  - Suckling,J
AU  - Taylor,EM
AU  - Bullmore,ET
AU  - Lingford-Hughes,AR
AU  - Deakin,B
AU  - Nutt,DJ
AU  - Sahakian,BJ
AU  - Robbins,TW
AU  - Voon,V
AU  - ICCAM,Consortium
DO  - 10.1111/adb.12503
EP  - 436
PY  - 2017///
SN  - 1369-1600
SP  - 425
TI  - Naltrexone ameliorates functional network abnormalities in alcohol-dependent individuals.
T2  - Addiction Biology
UR  - http://dx.doi.org/10.1111/adb.12503
UR  - http://hdl.handle.net/10044/1/45856
VL  - 23
ER  -
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