Imperial College London
Professor Danny O'Hare

ProfessorDannyO'Hare

Faculty of Engineering, Department of Bioengineering

Professor of Biosensor Technology
 
 
 
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Contact

 

+44 (0)20 7594 5173d.ohare

 
 
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Location

 

4.07Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{McLeod:2021:10.1016/j.elecom.2021.107147,
author = {McLeod, J and Stadler, E and Wilson, R and Holmes, A and O'Hare, D},
doi = {10.1016/j.elecom.2021.107147},
journal = {Electrochemistry Communications},
title = {Electrochemical detection of cefiderocol for therapeutic drug monitoring},
url = {http://dx.doi.org/10.1016/j.elecom.2021.107147},
volume = {133},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cefiderocol is a novel siderophore-conjugated β-lactam antibiotic which has been approved for clinical use. It has demonstrated efficacy against infections caused by  Gram-negative bacteria, including carbapenem-resistant strains. Novel antibiotics are rarely brought to market and, as such, are ideal candidates for therapeutic drug monitoring which enables optimised dosing across a range of clinical scenarios whilst also reducing the chances of antimicrobial resistance. Here we demonstrate direct electrochemical detection of cefiderocol by oxidation using untreated gold and glassy carbon electrodes as well as multi-walled carbon nanotube (MWCNT)-coated glassy carbon and foamed gold electrodes. Quantification of cefiderocol in the therapeutic range is demonstrated in spiked whole human blood using MWCNT-coated pyrolytic carbon screen-printed electrodes.
AU  - McLeod,J
AU  - Stadler,E
AU  - Wilson,R
AU  - Holmes,A
AU  - O'Hare,D
DO  - 10.1016/j.elecom.2021.107147
PY  - 2021///
SN  - 1388-2481
TI  - Electrochemical detection of cefiderocol for therapeutic drug monitoring
T2  - Electrochemistry Communications
UR  - http://dx.doi.org/10.1016/j.elecom.2021.107147
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000718145000001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S1388248121002319?via%3Dihub
UR  - http://hdl.handle.net/10044/1/92843
VL  - 133
ER  -
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