Imperial College London


Faculty of EngineeringDepartment of Bioengineering

Professor of Mechanobiology



+44 (0)20 7594 6376d.overby




3.07Bessemer BuildingSouth Kensington Campus





Darryl Overby earned his Ph.D. in Mechanical Engineering in 2002 from the Massachusetts Institute of Technology under the supervision of Dr. Mark Johnson and Prof. Roger Kamm for research on the mechanism of intraocular pressure regulation in relation to glaucoma. He spent 3 years as a post-doctoral research fellow at Harvard Medical School and Children’s Hospital Boston working under Prof. Donald Ingber in the area of cellular biomechanics and mechanotransduction in relation to vascular biology. Between October 2004 and June 2008, he served as Assistant Professor in the Department of Biomedical Engineering at Tulane University. He joined the academic staff at Imperial in July 2008.

Darryl’s research publications can be found at the tab above, or on Google Scholar

Selected Publications

Journal Articles

Sherwood JM, Stamer WD, Overby DR, 2019, A model of the oscillatory mechanical forces in the conventional outflow pathway, Journal of the Royal Society Interface, Vol:16, ISSN:1742-5662

Wu P-J, Kabovka I, Ruberti J, et al., 2018, Water content, not stiffness, dominates Brillouin spectroscopy measurements in hydrated materials, Nature Methods, Vol:15, ISSN:1548-7091, Pages:561-562

Chang JYH, Chow LW, Dismuke WM, et al., 2017, Peptide-functionalized fluorescent particles for in situ detection of nitric oxide via peroxynitrite-mediated nitration, Advanced Healthcare Materials, Vol:6, ISSN:2192-2640

Chandrawati R, Chang J, Reina-Torres E, et al., 2017, Localized and controlled delivery of nitric oxide to the conventional outflow pathway via enzyme biocatalysis: towards therapy for Glaucoma, Advanced Materials, Vol:29, ISSN:1521-4095

Overby DR, 2017, VEGF as a paracrine regulator of conventional outflow facility, Investigative Ophthalmology & Visual Science, Vol:58, ISSN:1552-5783, Pages:1899-1908

O'Callaghan J, Crosbie DE, Cassidy PS, et al., 2017, Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma, Human Molecular Genetics, Vol:26, ISSN:0964-6906, Pages:1230-1246

Sherwood JM, Reina-Torres E, Bertrand J, et al., 2016, Measurement of outflow facility using iPerfusion, PLOS One, Vol:11, ISSN:1932-6203, Pages:1-29

Chang JYH, Stamer WD, Bertrand J, et al., 2015, Role of nitric oxide in murine conventional outflow physiology, American Journal of Physiology - Cell Physiology, Vol:309, ISSN:0363-6143, Pages:C205-C214

Braakman ST, Read AT, Chan DW-H, et al., 2015, Colocalization of outflow segmentation and pores along the inner wall of Schlemm's canal, Experimental Eye Research, Vol:130, ISSN:0014-4835, Pages:87-96

Overby DR, Zhou EH, Vargas-Pinto R, et al., 2014, Altered mechanobiology of Schlemm's canal endothelial cells in glaucoma, Proceedings of the National Academy of Sciences of the United States of America, Vol:111, ISSN:0027-8424, Pages:13876-13881

Boussommier-Calleja A, Bertrand J, Woodward DF, et al., 2012, Pharmacologic Manipulation of Conventional Outflow Facility in Ex Vivo Mouse Eyes, Investigative Ophthalmology & Visual Science, Vol:53, ISSN:0146-0404, Pages:5838-5845

Pedrigi RM, Simon D, Reed A, et al., 2011, A model of giant vacuole dynamics in human Schlemm's canal endothelial cells, Experimental Eye Research, Vol:92, ISSN:0014-4835, Pages:57-66

Matthews BD, Thodeti CK, Tytell JD, et al., 2010, Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface beta 1 integrins, Integrative Biology, Vol:2, ISSN:1757-9694, Pages:435-442

Lu Z, Overby DR, Scott PA, et al., 2008, The mechanism of increasing outflow facility by rho-kinase inhibition with Y-27632 in bovine eyes, Experimental Eye Research, Vol:86, ISSN:0014-4835, Pages:271-281

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