Dr David R Owen MD PhD

Faculty of Medicine, Department of Brain Sciences

Reader in Molecular Pharmacology and Experimental Medicine

Contact

+44 (0)20 3313 6195d.owen Website

Location

G20AICTEM buildingHammersmith Campus

Summary

I am a clinical pharmacologist, and Head of Clinical Studies at the NIHR Imperial Clinical Research Facility (ICRF). The ICRF hosts clinical trials and experimental medicine studies to help Imperial College researchers turn their laboratory discoveries into medicines of the future.

My own research programme uses clinical and basic science studies to study the mitochondrial 18kDa Translocator Protein (TSPO). As a PhD student and post doc I worked on the pharmacology of TSPO as a PET imaging target, but I am currently investigating it as a drug target for CNS (neurodegeneration) and non CNS (pulmonary vascular disease) indications.

I spend the remaining ~20% of my time in clinical medicine seeing acute medical patients, leading Pharmacology teaching (with Chris John) at Imperial Medical School, directing the MRES in Clinical Research, and contributing to committees on the use of medicines. This includes chairing the North West London Integrated Formulary Committee which covers prescribing for approximately 2.6 million people, and chairing the Subregional IVIG committee covering the stewardship of this life saving but scarce resource across 6 NHS Trusts.

If you are interested in working on any of these projects, or wanting to start a new one in this field, please do get in touch.

Publications

Journals

Matthews P, 2024, A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer’s disease, Nature Communications

Knowles S, Middleton R, Cooze B, et al.Knowles S, Middleton R, Cooze B, Farkas I, Leung YY, Allen K, Winslade M, Owen DRJ, Magliozzi R, Reynolds R, Neal JW, Pearson O, Nicholas R, Pickrell WO, Howell OW, UK MS Register Research Group close, 2024, Comparing the pathology, clinical, and demographic characteristics of younger and older-onset multiple sclerosis, Annals of Neurology, Vol:95, ISSN:0364-5134, Pages:471-486

Nutma E, Fancy N, Weinert M, et al.Nutma E, Fancy N, Weinert M, Tsartsalis S, Marzin MC, Muirhead RCJ, Falk I, Breur M, de Bruin J, Hollaus D, Pieterman R, Anink J, Story D, Chandran S, Tang J, Trolese MC, Saito T, Saido TC, Wiltshire KH, Beltran-Lobo P, Phillips A, Antel J, Healy L, Dorion M-F, Galloway DA, Benoit RY, Amossé Q, Ceyzériat K, Badina AM, Kövari E, Bendotti C, Aronica E, Radulescu CI, Wong JH, Barron AM, Smith AM, Barnes SJ, Hampton DW, van der Valk P, Jacobson S, Howell OW, Baker D, Kipp M, Kaddatz H, Tournier BB, Millet P, Matthews PM, Moore CS, Amor S, Owen DR close, 2023, Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases, Nature Communications, Vol:14, ISSN:2041-1723, Pages:1-25

Mahmud M, Wade C, Jawad S, et al.Mahmud M, Wade C, Jawad S, Hadi Z, Otoul C, Kaminski RM, Muglia P, Kadiu I, Rabiner E, Maguire P, Johnson M, Owen D close, 2023, Translocator protein PET imaging in temporal lobe epilepsy: a reliable test-retest study using laterality index, Frontiers in Neuroimaging, Vol:2, ISSN:2813-1193, Pages:1-10

Writing Committee for the REMAP-CAP Investigators, Lawler PR, Derde LPG, et al.Writing Committee for the REMAP-CAP Investigators, Lawler PR, Derde LPG, van de Veerdonk FL, McVerry BJ, Huang DT, Berry LR, Lorenzi E, van Kimmenade R, Gommans F, Vaduganathan M, Leaf DE, Baron RM, Kim EY, Frankfurter C, Epelman S, Kwan Y, Grieve R, O'Neill S, Sadique Z, Puskarich M, Marshall JC, Higgins AM, Mouncey PR, Rowan KM, Al-Beidh F, Annane D, Arabi YM, Au C, Beane A, van Bentum-Puijk W, Bonten MJM, Bradbury CA, Brunkhorst FM, Burrell A, Buzgau A, Buxton M, Cecconi M, Cheng AC, Cove M, Detry MA, Estcourt LJ, Ezekowitz J, Fitzgerald M, Gattas D, Godoy LC, Goossens H, Haniffa R, Harrison DA, Hills T, Horvat CM, Ichihara N, Lamontagne F, Linstrum KM, McAuley DF, McGlothlin A, McGuinness SP, McQuilten Z, Murthy S, Nichol AD, Owen DRJ, Parke RL, Parker JC, Pollock KM, Reyes LF, Saito H, Santos MS, Saunders CT, Seymour CW, Shankar-Hari M, Singh V, Turgeon AF, Turner AM, Zarychanski R, Green C, Lewis RJ, Angus DC, Berry S, Gordon AC, McArthur CJ, Webb SA close, 2023, Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support–free days in patients hospitalized with COVID-19, Jama: Journal of the American Medical Association, Vol:329, ISSN:0098-7484, Pages:1183-1196

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