Publications
1024 results found
Taylor AM, Panting JR, Keegan J, et al., 1999, Use of the intravascular contrast agent NC100150 Injection in spin-echo and gradient-echo imaging of the heart, J.Cardiovascular MR, Vol: 1, Pages: 23-32
Taylor AM, Panting JR, Keegan J, et al., 1999, Use of the intravascular contrast agent NC100150 injection in spin-echo and gradient-echo imaging of the heart, JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, Vol: 1, Pages: 23-32, ISSN: 1097-6647
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- Citations: 37
Taylor AM, Stables RH, Poole-Wilson PA, et al., 1999, Definitive clinical assessment of atrial septal defect by magnetic resonance imaging, JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, Vol: 1, Pages: 43-47, ISSN: 1097-6647
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- Citations: 20
Taylor AM, Keegan J, Jhooti P, et al., 1999, Calculation of a subject specific adaptive motion correction factor for improved real-time navigator echo gated MR coronary angiography, J Cardiovasc Magn Reson, Pages: 131-138
Taylor AM, Panting JR, Keegan J, et al., 1999, Safety and preliminary findings with the new intravascular contrast agent, NC100150 injection, for MR coronary angiography, J Magn.Reson.Imag, Vol: 9, Pages: 220-227
Anagnostopoulos C, Pennell D, Francis J, et al., 1998, Erratum: A comparison of adenosine and arbutamine for myocardial perfusion imaging (European Journal of Nuclear Medicine (1998) 25 (394-400)), European Journal of Nuclear Medicine, Vol: 25, Pages: 1685-1686, ISSN: 0340-6997
Gunning MG, Anagnostopoulos C, Knight CJ, et al., 1998, Comparison of <SUP>201</SUP>Tl, <SUP>99m</SUP>Tc-tetrofosmin, and dobutamine magnetic resonance imaging for identifying hibernating myocardium, CIRCULATION, Vol: 98, Pages: 1869-1874, ISSN: 0009-7322
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- Citations: 75
Carr-White GS, Kon M, Koh TW, et al., 1998, Magnetic resonance imaging of right ventricular function after pulmonary autograft surgery, CIRCULATION, Vol: 98, Pages: 543-543, ISSN: 0009-7322
Pennell DJ, Manzara CC, Underwood SR, et al., 1998, Optimization of magnetic resonance imaging parameters for left ventricular wall motion studies at 0.5 T, BRITISH JOURNAL OF RADIOLOGY, Vol: 71, Pages: 1033-1039, ISSN: 0007-1285
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- Citations: 1
Yang GZ, Burger P, Panting J, et al., 1998, Motion and deformation tracking for short-axis echo-planar myocardial perfusion imaging., Med Image Anal, Vol: 2, Pages: 285-302, ISSN: 1361-8415
The assessment of regional myocardial perfusion during the first-pass of a contrast agent bolus requires tracking of the signal time course for each myocardial segment so that a detailed perfusion map can be derived. To obtain such a map in practice, however, is not trivial because deformation of the shape of the myocardium and respiratory-induced motion render a major difficulty in this process. This study describes an automated approach for motion and deformation tracking of functional myocardial perfusion images. The effectiveness of the described method has been evaluated using a numerical phantom and results are compared with those from existing techniques which use deformable models. Preliminary results from applying our approach to 20 patients are discussed and compared with those from SPECT studies.
Pennell DJ, Prvulovich E, Tweddel A, et al., 1998, Nuclear cardiology in the UK 1994: activity relative to Europe, USA, and British Cardiac Society targets, HEART, Vol: 80, Pages: 296-298, ISSN: 1355-6037
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- Citations: 5
Nagel E, Underwood R, Pennell D, et al., 1998, New developments in non-invasive cardiac imaging: critical assessment of the clinical role of cardiac magnetic resonance imaging, EUROPEAN HEART JOURNAL, Vol: 19, Pages: 1286-1293, ISSN: 0195-668X
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- Citations: 16
Pennell D, 1998, MR as a diagnostic tool in heart disease: What is the future?, MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE, Vol: 6, Pages: 189-190, ISSN: 0968-5243
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- Citations: 5
Prvulovich EM, Jarritt PH, Vivian GC, et al., 1998, Quality assurance in myocardial perfusion tomography: A collaborative BNCS/BNMS audit programme, NUCLEAR MEDICINE COMMUNICATIONS, Vol: 19, Pages: 831-838, ISSN: 0143-3636
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- Citations: 9
Nagel E, Underwood R, Penell D, et al., 1998, [Recent developments in non-invasive heart imaging. Critical evaluation of the use of cardiac magnetic resonance tomography--results of an interdisciplinary workshop]., Dtsch Med Wochenschr, Vol: 123, Pages: 1018-1021, ISSN: 0012-0472
Nagel E, Underwood R, Pennell D, et al., 1998, New developments of noninvasive cardiac imaging, Alpbach Meeting on New Developments in Noninvasive Cardiac Imaging, Publisher: GEORG THIEME VERLAG KG, Pages: 1018-1021, ISSN: 0012-0472
Jhooti P, Wiesmann F, Taylor A, et al., 1998, Hybrid ordered phase encoding (HOPE): an improved approach for respiratory artifact reduction, Journal of Magnetic Resonance Imaging, Vol: 8, Pages: 968-980
Gunning MG, Kaprielian RR, Pepper J, et al., 1998, Histology of hibernating myocardium characterised by Tl-201 imaging and dobutamine cine MRI, Heart, Vol: 79, ISSN: 1355-6037
Aim: To characterise the histology of hibernating myocardium based on pre-operative imaging features and post-operative functional recovery. Methods: We studied 21 patients with impaired left ventricular function scheduled for CABG. All underwent stress and separate day rest Tl-201 scintigraphy, and low-dose dobutamine MRI pre-operatively. At CABG transmural biopsies were taken from up to 4 myocardial segments per patient. Follow-up rest MRI was conducted after 3-6 months. Significantly hypocontractile segments of myocardium (on pre-op MRI) were evaluated for response to dobutamine, reversible ischaemia, rest Tl-201 uptake and functional recovery. Segments were classified as hibernating if wall motion improved by ≥1 grade following CABG. Biopsy specimens were assessed for % connective tissue content(CT), degree of glycogen accumulation(GLY), and degree of myocyte loss(ML). Results: Comparing hibernating and non-hibernating segments(scar), mean CT was 29.3±15.8% vs 38.1±23.7%(p=ns), mean GLY was 1.1±1 vs 1.5±0.9(p=ns), and mean ML was 1.4±1.2 vs 1.2±0.9(p=ns) respectively. On pre-operative MRI, comparing segments which responded to dobutamine to those that did not, CT was 23.1±7.2 vs 35.3±21.3%(p<0.05), GLY was 1.2±0.8 vs 1.2±1(p=ns) and ML was 1.7±1 vs 1.3±1.1(p=ns) respectively. For segments with Tl-201 uptake ≥60% vs uptake <60%, CT was 28.4±16 vs 36.4±22.7%(p=ns). Comparing ischaemic vs non-ischaemic segments CT was 30.8±18.1 vs 32.1±19.7%, GLY was 1.1±1 vs 1.3±1.1(p=ns), and ML was 1.4±1.2 vs 1.2±1.1(p=ns) respectively. Conclusions: Regions of myocardium displaying inotropic repense to dobutamine contain significantly less fibrous tissue than non-responsive regions. Hibernating myocardium contains less fibrous tissue than scar but the difference is not significant. Glycogen accumulation and myocyte loss do not de
Panting JR, Gatehouse PD, Yang GZ, et al., 1998, Myocardial perfusion imaging by MR: Optimisation of multislice single shot echo-planar imaging at 0.5T, Heart, Vol: 79, ISSN: 1355-6037
Perfusion imaging is important in the assessment of the physiological significance of ischaemic heart disease. First pass MR techniques have advantages over SPECT (lack of radiation and higher resolution). We have previously demonstrated good correlation of MR and SPECT with a spin echo, echo-planar MR technique, but these studies imaged only a single slice, which is not clinically viable. In order to improve coverage, we have now assessed methods of multislice MRI. We studied 8 normal subjects, 4 using a Single Inversion Pulse (SIP), to null myocardial signal, before imaging all the slices in rapid succession, and 4 where Multiple Inversion Pulses (MIP) were used, one before each slice. In all cases the image acquisition time was 100 ms. With SIP, there was an inversion delay of 200 ms before the first acquisition, with minimal delay between images, however with MIP, there was a delay of 100 ms before each image acquisition, increasing the apparent acquisition time of each slice to 200ms. With SIP the baseline signal intensity varied with length of time after inversion pulse to slice acquisition. Despite this, the net signal change with contrast for each slice was similar and all slices were evaluable. With MIP, the signal intensity was similar in all slices, but the increase in apparent acquisition time typically limited the maximum number of slices to 3. When compared to the 5 slices obtained with SIP, complete coverage of the ventricle was limited with MIP. Following these results we pursued a study of 20 patients with coronary artery disease using SIP during rest and stress with adenosine. Correlation with SPECT was good in all cases, good coverage of the LV possible, and defects were not missed by MR because of the non-contiguity of slices. Thus with further development, this MR technique is a candidate rival for SPECT in clinical practice, but large comparative studies are required.
Mohiaddin RH, Pennell DJ, 1998, MR BLOOD FLOW MEASUREMENT, Cardiology Clinics, Vol: 16, Pages: 161-187, ISSN: 0733-8651
Mohiaddin RH, Pennell DJ, 1998, MR blood flow measurement. Clinical application in the heart and circulation., Cardiol Clin, Vol: 16, Pages: 161-187, ISSN: 0733-8651
Several magnetic resonance imaging methods for measuring blood flow have greatly enhanced the capability of magnetic resonance imaging as a physiologic tool in cardiology. This article concentrates on phase-related techniques. Magnetic resonance velocity mapping is a flexible, robust, and accurate method of obtaining functional information in the cardiovascular system. It has the potential to contribute significantly to clinical decision making, and it should be a routine part of cardiovascular imaging whenever information on flow is required.
Pennell DJ, Prvulovich E, Tweddel A, et al., 1998, Nuclear cardiology in the UK: British Nuclear Cardiology Society survey 1994, NUCLEAR MEDICINE COMMUNICATIONS, Vol: 19, Pages: 305-313, ISSN: 0143-3636
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- Citations: 18
Anagnostopoulos C, Pennell D, Francis J, et al., 1998, A comparison of adenosine and arbutamine for myocardial perfusion imaging, EUROPEAN JOURNAL OF NUCLEAR MEDICINE, Vol: 25, Pages: 394-400, ISSN: 0340-6997
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- Citations: 4
Kaprielian RR, Gunning M, Dupont E, et al., 1998, Downregulation of immunodetectable connexin43 and decreased gap junction size in the pathogenesis of chronic hibernation in the human left ventricle, CIRCULATION, Vol: 97, Pages: 651-660, ISSN: 0009-7322
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- Citations: 180
Pennell DJ, Prvulovich E, Tweddel A, et al., 1998, Nuclear cardiology in the uk british nuclear cardiology society survey 1994, Nuclear Medicine Communications, Vol: 19, Pages: 305-314, ISSN: 0143-3636
This study surveyed practice in nuclear cardiology in the UK in 1994. A questionnaire was sent to 219 centres performing nuclear imaging asking for details of current practice in nuclear cardiology. Replies were received from 192 centres (88%). Activity in performance of myocardial perfusion imaging (MPI) and radionuclide ventriculography (RNV), anticipated changes in activity, differences between regional and district general hospitals, technical imaging parameters and referral sources were surveyed. Of the responding centres, 125 (65%) performed nuclear cardiology. More regional centres (85 vs 55%, P < 0.0003) performed a higher proportion (62 vs 24%, P < 0.001) of nuclear cardiology activity compared with district general hospitals. Nuclear medicine activity was estimated at 9.3 scans/1000/year, of which 8.9% was cardiology (0.82/1000/year; MPI, 0.56/1000/year; RNV, 0.26/1000/year). A comparison with previous surveys showed a significant increase of 24% in nuclear cardiology since 1988, with a strong rise in MPI (350%); however, RNV has fallen by 47%. Myocardial perfusion activity in the UK remains very low (25 and 5% for MPI and RNV respectively) when compared with the average of 2.2/1000/year for Europe and 10.8/1000/year for the USA. In conclusion, MPI has increased on average by 23% per annum (compound rate) since 1988, but in 1994 was still only 32% of the British Cardiac Society target of 2.6 scans/1000/year. Proper resourcing for capital expenditure on new equipment and new staff will be important to maintain momentum in closing the gap. Also important is clinical understanding, as already implemented by including nuclear cardiology in guidelines for specialist cardiology training. © 1998 Chapman and Hall Ltd.
Pennell D, Casolo G, 1997, Right ventricular arrhythmia: emergence of magnetic resonance imaging as an investigative tool, EUROPEAN HEART JOURNAL, Vol: 18, Pages: 1843-1845, ISSN: 0195-668X
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- Citations: 29
Taylor AM, Pennell DJ, 1997, Magnetic resonance imaging of the coronary arteries: Recent progress and limitations, British Journal of Cardiology, Vol: 4, Pages: 319-322, ISSN: 0969-6113
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- Citations: 1
Ellman A, Smith D, Patel J, et al., 1997, Functional myocardial imaging - DSE v. MPI - Round-table discussion, SOUTH AFRICAN MEDICAL JOURNAL, Vol: 87, Pages: C291-C295, ISSN: 0038-2469
ORegan DJ, Borland JAA, Chester AH, et al., 1997, Assessment of human long saphenous vein function with minimally invasive harvesting with the Mayo stripper, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 12, Pages: 428-435, ISSN: 1010-7940
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- Citations: 22
Wiesmann F, Taylor AM, Neubauer S, et al., 1997, [Current value of magnetic resonance imaging for diagnosis of coronary heart disease]., Z Kardiol, Vol: 86, Pages: 657-668, ISSN: 0300-5860
Magnetic Resonance Imaging (MRI) is a non-invasive imaging technique with increasing importance in clinical medicine. It has become a valuable and reliable imaging tool in the diagnosis and management of many medical and surgical conditions. Important advantages of MRI are its flexibility in orientation of imaging plane and the possibility of both anatomical and functional imaging. MRI is based on the application and detection of radio signals and works without any exposure to ionizing radiation, and therefore it is regarded as a safe imaging technique. In the heart there are well established imaging indications such as in acquired and congenital heart disease, pericardial and aortic disease and visualisation of cardiac masses and hypertrophy. Its applications in coronary artery disease (CAD) have been relatively limited, but recent developments in ultrafast imaging sequences and computer hardware have led to a considerable improvement in spatial and temporal image resolution. This has made applications in CAD a possibility, particularly coronary imaging and myocardial perfusion imaging. Recent clinical studies report good correlation between Magnetic Resonance Coronary Angiography (MRCA) and conventional x-ray contrast angiography in the detection of coronary lesions. In the assessment of coronary artery bypass graft (CABG) patency and the definition of anomalous coronary arteries, MRI showed good sensitivity and specificity. The first results of coronary artery flow measurements have now been reported. Myocardial perfusion imaging and stress-ventriculography for detection of wall motion abnormalities are reported as indirect imaging methods with high reliability and clinical value in the diagnosis of CAD. This overview describes recent developments in cardiac MRI and assesses the current and future value of MRI for clinical cardiology.
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