Imperial College London
Alternate

Dr David L Constable-Phelps

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Clinical Lecturer
 
 
 
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+44 (0)20 7594 2125d.phelps

 
 
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Summary

 

Publications

Citation

BibTex format

@article{Ahmed-Salim:2021:10.31083/j.ejgo4204102,
author = {Ahmed-Salim, Y and Saso, S and Meehan, H and Galazis, N and Phelps, D and Jones, B and Chan, M and Chawla, M and Lathouras, K and Gabra, H and Fotopoulou, C and Ghaem-Maghami, S and Smith, JR},
doi = {10.31083/j.ejgo4204102},
journal = {European Journal of Gynecological Oncology},
pages = {662--672},
title = {A novel application of calcium electroporation to cutaneous manifestations of gynaecological cancer},
url = {http://dx.doi.org/10.31083/j.ejgo4204102},
volume = {42},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Introduction: Calcium electroporation (CaEP) is a new technique whereby intracellular concentrations of calcium are elevated by transient permeabilisation of the cell membrane using high-voltage electrical pulses. Tumour necrosis is induced with little damage to healthy tissue. Within gynaecological cancer, vulval cancer and vulval intraepithelial neoplasia (VIN) pose challenges for treatment, given the high recurrence rate, persistent symptoms and repeated resections required. In certain cases, CaEP may provide a suitable alternative.Methods: We present a case series of six patients with recurrent vulval squamous cell carcinoma(n=2), VIN III (n=2) and metastatic ovarian cancer (n=2), five of whom were treated with CaEP. This is the first known application of CaEP to gynaecological cancers .Results: The median follow-up time was 14 months (range 2-18 months). Within the cohort of patients, CaEP was applied a total of 10 times, achieving a complete response five times and partial response four times. Symptoms improved within six weeks for eight episodes following CaEP application. Beyond six weeks, symptoms eventually recurred in all patients and four patients required more than one CaEP procedure. CaEP was useful for palliation of distressing symptoms in one case of metastatic ovarian cancer. No intra-operative or post-operative complications have been reported to date. Conclusion: CaEP may be a promising short-term treatment in selected patients with recurrent VIN and vulval cancer, where other treatments had failed. If validated, it could provide an acceptable alternative where surgery is unacceptable. Long term follow-up is required to evaluate effects on recurrence.
AU  - Ahmed-Salim,Y
AU  - Saso,S
AU  - Meehan,H
AU  - Galazis,N
AU  - Phelps,D
AU  - Jones,B
AU  - Chan,M
AU  - Chawla,M
AU  - Lathouras,K
AU  - Gabra,H
AU  - Fotopoulou,C
AU  - Ghaem-Maghami,S
AU  - Smith,JR
DO  - 10.31083/j.ejgo4204102
EP  - 672
PY  - 2021///
SN  - 0392-2936
SP  - 662
TI  - A novel application of calcium electroporation to cutaneous manifestations of gynaecological cancer
T2  - European Journal of Gynecological Oncology
UR  - http://dx.doi.org/10.31083/j.ejgo4204102
UR  - https://ejgo.imrpress.com/EN/10.31083/j.ejgo4204102
UR  - http://hdl.handle.net/10044/1/88613
VL  - 42
ER  -
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