Imperial College London
Alternate

ProfessorDarylWilliams

Faculty of Engineering, Department of Chemical Engineering

Professor of Particle Science
 
 
 
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Contact

 

+44 (0)20 7594 5611d.r.williams Website

 
 
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Location

 

439ACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{Hedberg:2019:10.1007/978-1-4939-8928-7_13,
author = {Hedberg, SHM and Devi, S and Duralliu, A and Williams, DR},
booktitle = {Methods in Pharmacology and Toxicology},
doi = {10.1007/978-1-4939-8928-7_13},
pages = {327--351},
title = {Mechanical behavior and structure of freeze-dried cakes},
url = {http://dx.doi.org/10.1007/978-1-4939-8928-7_13},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - CHAP
AB  - Freeze-drying or the lyophilization of biopharmaceuticals is a standard method for product manufacture in order to increase product shelf-life and minimize the tendency of re-constituted products to aggregate. However, the physical and or mechanical stability of freeze-dried cakes can be problematic, which can directly result in financial losses due to unusable or damaged products. Currently, there is very limited systematic knowledge of the relationship between lyophilization process conditions and the cake-specific physical structure, mechanical performance, and stability. This Chapter reviews the detailed mechanical properties and structure of freeze-dried cakes formed from aqueous solutions with concentrations from 1 to 40% w/v of common excipients, mannitol, sucrose, and trehalose in some detail. In addition, the mechanical properties of commercial freeze-dried products as well as effects of moisture content and ingress into freeze-dried cakes are also reported. Both experimentally measured Young’s moduli and yield stress data scale well with reduced cake density, in line with theoretical predictions from classical cellular solids theory. A novel compressive indentation method is reviewed which can accurately determine a cake’s Young’s modulus and yield stress within 1 min, allowing the potential future use of these mechanical cake attributes as Critical Quality Attributes (CQAs).
AU  - Hedberg,SHM
AU  - Devi,S
AU  - Duralliu,A
AU  - Williams,DR
DO  - 10.1007/978-1-4939-8928-7_13
EP  - 351
PY  - 2019///
SP  - 327
TI  - Mechanical behavior and structure of freeze-dried cakes
T1  - Methods in Pharmacology and Toxicology
UR  - http://dx.doi.org/10.1007/978-1-4939-8928-7_13
ER  -
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