Imperial College London
Alternate

Dr David Laith Rawaf

Faculty of Medicine, School of Public Health

Web Editor for the WHO Collaborating Centre
 
 
 
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Contact

 

d.rawaf Website

 
 
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Location

 

Reynolds BuildingCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{GBD:2022:10.1016/S1470-2045(21)00581-7,
author = {GBD, 2019 Adolescent Young Adult Cancer Collaborators},
doi = {10.1016/S1470-2045(21)00581-7},
journal = {The Lancet Oncology},
pages = {27--52},
title = {The global burden of adolescent and young adult cancer in 2019: a systematic analysis for the Global Burden of Disease Study 2019},
url = {http://dx.doi.org/10.1016/S1470-2045(21)00581-7},
volume = {23},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. METHODS: Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15-39 years to define adolescents and young adults. FINDINGS: There were 1·19 million (95% UI 1·11-1·28) incident cancer cases and 396000 (370000-425000) deaths due to cancer among people aged 15-39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59·6 [54·5-65·7] per 100000 person-years) and high-middle SDI countries (53·2 [48·8-57·9] per 100000 person-years), while the high
AU  - GBD,2019 Adolescent Young Adult Cancer Collaborators
DO  - 10.1016/S1470-2045(21)00581-7
EP  - 52
PY  - 2022///
SN  - 1213-9432
SP  - 27
TI  - The global burden of adolescent and young adult cancer in 2019: a systematic analysis for the Global Burden of Disease Study 2019
T2  - The Lancet Oncology
UR  - http://dx.doi.org/10.1016/S1470-2045(21)00581-7
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34871551
UR  - http://hdl.handle.net/10044/1/94637
VL  - 23
ER  -
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