Imperial College London
Alternate

Dr David Laith Rawaf

Faculty of Medicine, School of Public Health

Web Editor for the WHO Collaborating Centre
 
 
 
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d.rawaf Website

 
 
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Reynolds BuildingCharing Cross Campus

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Publications

Citation

BibTex format

@article{Schmidt:2022:10.1186/s12916-022-02486-y,
author = {Schmidt, CA and Cromwell, EA and Hill, E and Donkers, KM and Schipp, MF and Johnson, KB and Pigott, DM and Schmidt, CA and Cromwell, EA and Hill, E and Pigott, DM and Abbas, J and Adekanmbi, V and Adetokunboh, OO and Ahmed, MB and Alanezi, FM and Alanzi, TM and Alipour, V and Andrei, CL and Andrei, T and Anvari, D and Appiah, SCY and Aqeel, M and Arabloo, J and Jafarabadi, MA and Ausloos, M and Baig, AA and Banach, M and Bärnighausen, TW and Bhattacharyya, K and Bhutta, ZA and Bijani, A and Brady, OJ and Bragazzi, NL and Butt, ZA and Carvalho, F and Chattu, VK and Dahlawi, SMA and Damiani, G and Demeke, FM and Deribe, K and Dharmaratne, SD and Diaz, D and Didarloo, A and Earl, L and Zaki, MES and El, Tantawi M and Fattahi, N and Fernandes, E and Foigt, NA and Foroutan, M and Franklin, RC and Guo, Y and Haj-Mirzaian, A and Hamidi, S and Hassankhani, H and Herteliu, C and Higazi, TB and Hosseini, M and Hosseinzadeh, M and Househ, M and Ilesanmi, OS and Ilic, IM and Ilic, MD and Irvani, S},
doi = {10.1186/s12916-022-02486-y},
journal = {BMC Medicine},
title = {The prevalence of onchocerciasis in Africa and Yemen, 2000–2018: a geospatial analysis},
url = {http://dx.doi.org/10.1186/s12916-022-02486-y},
volume = {20},
year = {2022}
}
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TY  - JOUR
AB  - BackgroundOnchocerciasis is a disease caused by infection with Onchocerca volvulus, which is transmitted to humans via the bite of several species of black fly, and is responsible for permanent blindness or vision loss, as well as severe skin disease. Predominantly endemic in parts of Africa and Yemen, preventive chemotherapy with mass drug administration of ivermectin is the primary intervention recommended for the elimination of its transmission.MethodsA dataset of 18,116 geo-referenced prevalence survey datapoints was used to model annual 2000–2018 infection prevalence in Africa and Yemen. Using Bayesian model-based geostatistics, we generated spatially continuous estimates of all-age 2000–2018 onchocerciasis infection prevalence at the 5 × 5-km resolution as well as aggregations to the national level, along with corresponding estimates of the uncertainty in these predictions.ResultsAs of 2018, the prevalence of onchocerciasis infection continues to be concentrated across central and western Africa, with the highest mean estimates at the national level in Ghana (12.2%, 95% uncertainty interval [UI] 5.0–22.7). Mean estimates exceed 5% infection prevalence at the national level for Cameroon, Central African Republic, Democratic Republic of the Congo (DRC), Guinea-Bissau, Sierra Leone, and South Sudan.ConclusionsOur analysis suggests that onchocerciasis infection has declined over the last two decades throughout western and central Africa. Focal areas of Angola, Cameroon, the Democratic Republic of the Congo, Ethiopia, Ghana, Guinea, Mali, Nigeria, South Sudan, and Uganda continue to have mean microfiladermia prevalence estimates exceeding 25%. At and above this level, the continuation or initiation of mass drug administration with ivermectin is supported. If national programs aim to eliminate onchocerciasis infection, additional surveillance or supervision of areas of predicted high prevalence would be warranted to ensure sufficiently high c
AU  - Schmidt,CA
AU  - Cromwell,EA
AU  - Hill,E
AU  - Donkers,KM
AU  - Schipp,MF
AU  - Johnson,KB
AU  - Pigott,DM
AU  - Schmidt,CA
AU  - Cromwell,EA
AU  - Hill,E
AU  - Pigott,DM
AU  - Abbas,J
AU  - Adekanmbi,V
AU  - Adetokunboh,OO
AU  - Ahmed,MB
AU  - Alanezi,FM
AU  - Alanzi,TM
AU  - Alipour,V
AU  - Andrei,CL
AU  - Andrei,T
AU  - Anvari,D
AU  - Appiah,SCY
AU  - Aqeel,M
AU  - Arabloo,J
AU  - Jafarabadi,MA
AU  - Ausloos,M
AU  - Baig,AA
AU  - Banach,M
AU  - Bärnighausen,TW
AU  - Bhattacharyya,K
AU  - Bhutta,ZA
AU  - Bijani,A
AU  - Brady,OJ
AU  - Bragazzi,NL
AU  - Butt,ZA
AU  - Carvalho,F
AU  - Chattu,VK
AU  - Dahlawi,SMA
AU  - Damiani,G
AU  - Demeke,FM
AU  - Deribe,K
AU  - Dharmaratne,SD
AU  - Diaz,D
AU  - Didarloo,A
AU  - Earl,L
AU  - Zaki,MES
AU  - El,Tantawi M
AU  - Fattahi,N
AU  - Fernandes,E
AU  - Foigt,NA
AU  - Foroutan,M
AU  - Franklin,RC
AU  - Guo,Y
AU  - Haj-Mirzaian,A
AU  - Hamidi,S
AU  - Hassankhani,H
AU  - Herteliu,C
AU  - Higazi,TB
AU  - Hosseini,M
AU  - Hosseinzadeh,M
AU  - Househ,M
AU  - Ilesanmi,OS
AU  - Ilic,IM
AU  - Ilic,MD
AU  - Irvani,SSN
AU  - Jha,RP
AU  - Ji,JS
AU  - Jonas,JB
AU  - Jozwiak,JJ
AU  - Kalankesh,LR
AU  - Kamyari,N
AU  - Matin,BK
AU  - Karimi,SE
AU  - Kayode,GA
AU  - Karyani,AK
AU  - Khan,EA
AU  - Khan,MN
AU  - Khatab,K
AU  - Khater,MM
AU  - Kianipour,N
AU  - Kim,YJ
AU  - Kosen,S
AU  - Kusuma,D
AU  - La,Vecchia C
AU  - Lansingh,VC
AU  - Lee,PH
AU  - Li,S
AU  - Maleki,S
AU  - Mansournia,MA
AU  - Martins-Melo,FR
AU  - McAlinden,C
AU  - Mendoza,W
AU  - Mestrovic,T
AU  - Moghadaszadeh,M
AU  - Mohammadian-Hafshejani,A
AU  - Mohammadi,SM
AU  - Mohammed,S
AU  - Moradzadeh,R
AU  - Moraga,P
AU  - Naderi,M
AU  - Nagarajan,AJ
AU  - Negoi,I
AU  - Nguyen,CT
AU  - Nguyen,HLT
AU  - Oancea,B
AU  - Olagunju,AT
AU  - Bali,AO
AU  - Onwujekwe,OE
AU  - Pana,A
AU  - Rahimi-Movaghar,V
AU  - Ramezanzadeh,K
AU  - Rawaf,DL
AU  - Rawaf,S
AU  - Rawassizadeh,R
AU  - Rezapour,A
AU  - Ribeiro,AI
AU  - Samy,AM
AU  - Shaikh,MA
AU  - Sharafi,K
AU  - Sheikh,A
AU  - Singh,JA
AU  - Skiadaresi,E
AU  - Soltani,S
AU  - Stolk,WA
AU  - Sufiyan,MB
AU  - Thomson,AJ
AU  - Tran,BX
AU  - Tran,KB
AU  - Unnikrishnan,B
AU  - Violante,FS
AU  - Vu,GT
AU  - Yamada,T
AU  - Yaya,S
AU  - Yip,P
AU  - Yonemoto,N
AU  - Yu,C
AU  - Yu,Y
AU  - Zamanian,M
AU  - Zhang,Y
AU  - Zhang,Z-J
AU  - Ziapour,A
AU  - Hay,SI
AU  - Hay,SI
DO  - 10.1186/s12916-022-02486-y
PY  - 2022///
SN  - 1741-7015
TI  - The prevalence of onchocerciasis in Africa and Yemen, 2000–2018: a geospatial analysis
T2  - BMC Medicine
UR  - http://dx.doi.org/10.1186/s12916-022-02486-y
UR  - https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-022-02486-y
UR  - http://hdl.handle.net/10044/1/99495
VL  - 20
ER  -
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