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BibTex format

author = {Braga, RM and Roze, E and Ball, G and Merchant, N and Tusor, N and Arichi, T and Edwards, D and Rueckert, D and Counsell, SJ},
doi = {10.1371/journal.pone.0125681},
journal = {PLOS One},
title = {Development of the Corticospinal and Callosal Tracts from Extremely Premature Birth up to 2 Years of Age},
url = {},
volume = {10},
year = {2015}

RIS format (EndNote, RefMan)

AB - White matter tracts mature asymmetrically during development, and this development canbe studied using diffusion magnetic resonance imaging. The aims of this study were i. togenerate dynamic population-averaged white matter registration templates covering in detailthe period from 25 weeks gestational age to term, and extending to 2 years of age basedon DTI and fractional anisotropy, ii. to produce tract-specific probability maps of the corticospinaltracts, forceps major and forceps minor using probabilistic tractography, and iii. toassess the development of these tracts throughout this critical period of neurodevelopment.We found evidence for asymmetric development across the fiber bundles studied, with thecorticospinal tracts showing earlier maturation (as measured by fractional anisotropy) butslower volumetric growth compared to the callosal fibers. We also found evidence for an anteriorto posterior gradient in white matter microstructure development (as measured bymean diffusivity) in the callosal fibers, with the posterior forceps major developing at a fasterrate than the anterior forceps minor in this age range. Finally, we report a protocol for delineatingcallosal and corticospinal fibers in extremely premature cohorts, and make availablepopulation-averaged registration templates and a probabilistic tract atlas which we hope willbe useful for future neonatal and infant white-matter imaging studies.
AU - Braga,RM
AU - Roze,E
AU - Ball,G
AU - Merchant,N
AU - Tusor,N
AU - Arichi,T
AU - Edwards,D
AU - Rueckert,D
AU - Counsell,SJ
DO - 10.1371/journal.pone.0125681
PY - 2015///
SN - 1932-6203
TI - Development of the Corticospinal and Callosal Tracts from Extremely Premature Birth up to 2 Years of Age
T2 - PLOS One
UR -
UR -
VL - 10
ER -