Imperial College London


Faculty of EngineeringDepartment of Computing

Head of Department of Computing



+44 (0)20 7594 8333d.rueckert Website




568Huxley BuildingSouth Kensington Campus






BibTex format

author = {Newcombe, VFJ and Correia, MM and Ledig, C and Abate, MG and Outtrim, JG and Chatfield, D and Geeraerts, T and Manktelow, AE and Garyfallidis, E and Pickard, JD and Sahakian, BJ and Hutchinson, PJA and Rueckert, D and Coles, JP and Williams, GB and Menon, DK},
doi = {10.1177/1545968315584004},
journal = {Neurorehabilitation and Neural Repair},
pages = {49--62},
title = {Dynamic Changes in White Matter Abnormalities Correlate With Late Improvement and Deterioration Following TBI: A Diffusion Tensor Imaging Study},
url = {},
volume = {30},
year = {2015}

RIS format (EndNote, RefMan)

AB - Objective. Traumatic brain injury (TBI) is not a single insult with monophasic resolution, but a chronic disease, with dynamic processes that remain active for years. We aimed to assess patient trajectories over the entire disease narrative, from ictus to late outcome. Methods. Twelve patients with moderate-to-severe TBI underwent magnetic resonance imaging in the acute phase (within 1 week of injury) and twice in the chronic phase of injury (median 7 and 21 months), with some undergoing imaging at up to 2 additional time points. Longitudinal imaging changes were assessed using structural volumetry, deterministic tractography, voxel-based diffusion tensor analysis, and region of interest analyses (including corpus callosum, parasagittal white matter, and thalamus). Imaging changes were related to behavior. Results. Changes in structural volumes, fractional anisotropy, and mean diffusivity continued for months to years postictus. Changes in diffusion tensor imaging were driven by increases in both axial and radial diffusivity except for the earliest time point, and were associated with changes in reaction time and performance in a visual memory and learning task (paired associates learning). Dynamic structural changes after TBI can be detected using diffusion tensor imaging and could explain changes in behavior. Conclusions. These data can provide further insight into early and late pathophysiology, and begin to provide a framework that allows magnetic resonance imaging to be used as an imaging biomarker of therapy response. Knowledge of the temporal pattern of changes in TBI patient populations also provides a contextual framework for assessing imaging changes in individuals at any given time point.
AU - Newcombe,VFJ
AU - Correia,MM
AU - Ledig,C
AU - Abate,MG
AU - Outtrim,JG
AU - Chatfield,D
AU - Geeraerts,T
AU - Manktelow,AE
AU - Garyfallidis,E
AU - Pickard,JD
AU - Sahakian,BJ
AU - Hutchinson,PJA
AU - Rueckert,D
AU - Coles,JP
AU - Williams,GB
AU - Menon,DK
DO - 10.1177/1545968315584004
EP - 62
PY - 2015///
SN - 1552-6844
SP - 49
TI - Dynamic Changes in White Matter Abnormalities Correlate With Late Improvement and Deterioration Following TBI: A Diffusion Tensor Imaging Study
T2 - Neurorehabilitation and Neural Repair
UR -
VL - 30
ER -