Imperial College London


Faculty of EngineeringDepartment of Computing

Head of Department of Computing



+44 (0)20 7594 8333d.rueckert Website




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BibTex format

author = {Rueckert, D and Aljabar, P},
booktitle = {Handbook of Biomedical Imaging: Methodologies and Clinical Research},
doi = {10.1007/978-0-387-09749-7_15},
pages = {277--294},
title = {Non-rigid registration using free-form deformations},
url = {},
year = {2015}

RIS format (EndNote, RefMan)

AB - © Springer Science+Business Media New York 2015. Free-form deformations are a powerful geometric modeling technique which can be used to represent complex 3D deformations. In recent years, freeform deformations have gained significant popularity in algorithms for the non-rigid registration of medical images. In this chapter we show how free-form deformations can be used in non-rigid registration to model complex local deformations of 3D organs. In particular, we discuss diffeomorphic and non-diffeomorphic representations of 3D deformation fields using free-form deformations as well as different penalty functions that can be used to constrain the deformation fields during the registration.We also show how free-form deformations can be used in combination with mutual information-based similarity metrics for the registration ofmono-modal and multi-modal medical images. Finally, we discuss applications of registration techniques based on free-form deformations for the analysis of images of the breast, heart and brain as well as for segmentation and shape modelling.
AU - Rueckert,D
AU - Aljabar,P
DO - 10.1007/978-0-387-09749-7_15
EP - 294
PY - 2015///
SN - 9780387097480
SP - 277
TI - Non-rigid registration using free-form deformations
T1 - Handbook of Biomedical Imaging: Methodologies and Clinical Research
UR -
ER -