Imperial College London
Alternate

ProfessorDanielRueckert

Faculty of Engineering, Department of Computing

Professor of Visual Information Processing
 
 
 
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Contact

 

+44 (0)20 7594 8333d.rueckert Website

 
 
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Location

 

568Huxley BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Neubauer:2022:10.1016/j.nicl.2022.103286,
author = {Neubauer, A and Menegaux, A and Wendt, J and Li, HB and Schmitz-Koep, B and Ruzok, T and Thalhammer, M and Schinz, D and Bartmann, P and Wolke, D and Priller, J and Zimmer, C and Rueckert, D and Hedderich, DM and Sorg, C},
doi = {10.1016/j.nicl.2022.103286},
journal = {NeuroImage: Clinical},
pages = {1--16},
title = {Aberrant claustrum structure in preterm-born neonates: an MRI study.},
url = {http://dx.doi.org/10.1016/j.nicl.2022.103286},
volume = {37},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The human claustrum is a gray matter structure in the white matter between insula and striatum. Previous analysis found altered claustrum microstructure in very preterm-born adults associated with lower cognitive performance. As the claustrum development is related to hypoxia-ischemia sensitive transient cell populations being at-risk in premature birth, we hypothesized that claustrum structure is already altered in preterm-born neonates. We studied anatomical and diffusion-weighted MRIs of 83 preterm- and 83 term-born neonates at term-equivalent age. Additionally, claustrum development was analyzed both in a spectrum of 377 term-born neonates and longitudinally in 53 preterm-born subjects. Data was provided by the developing Human Connectome Project. Claustrum development showed increasing volume, increasing fractional anisotropy (FA), and decreasing mean diffusivity (MD) around term both across term- and preterm-born neonates. Relative to term-born ones, preterm-born neonates had (i) increased absolute and relative claustrum volumes, both indicating increased cellular and/or extracellular matter and being in contrast to other subcortical gray matter regions of decreased volumes such as thalamus; (ii) lower claustrum FA and higher claustrum MD, pointing at increased extracellular matrix and impaired axonal integrity; and (iii) aberrant covariance between claustrum FA and MD, respectively, and that of distributed gray matter regions, hinting at relatively altered claustrum microstructure. Results together demonstrate specifically aberrant claustrum structure in preterm-born neonates, suggesting altered claustrum development in prematurity, potentially relevant for later cognitive performance.
AU  - Neubauer,A
AU  - Menegaux,A
AU  - Wendt,J
AU  - Li,HB
AU  - Schmitz-Koep,B
AU  - Ruzok,T
AU  - Thalhammer,M
AU  - Schinz,D
AU  - Bartmann,P
AU  - Wolke,D
AU  - Priller,J
AU  - Zimmer,C
AU  - Rueckert,D
AU  - Hedderich,DM
AU  - Sorg,C
DO  - 10.1016/j.nicl.2022.103286
EP  - 16
PY  - 2022///
SN  - 2213-1582
SP  - 1
TI  - Aberrant claustrum structure in preterm-born neonates: an MRI study.
T2  - NeuroImage: Clinical
UR  - http://dx.doi.org/10.1016/j.nicl.2022.103286
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36516730
UR  - https://www.sciencedirect.com/science/article/pii/S2213158222003515?via%3Dihub
UR  - http://hdl.handle.net/10044/1/101353
VL  - 37
ER  -
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