Publications
145 results found
Rajappan K, Rimoldi OE, Camici PG, et al., 2003, Functional changes in coronary microcirculation after valve replacement in patients with aortic stenosis, CIRCULATION, Vol: 107, Pages: 3170-3175, ISSN: 0009-7322
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- Citations: 159
Rajappan K, Bellenger NG, Melina G, et al., 2003, Assessment of left ventricular mass regression after aortic valve replacement - cardiovascular magnetic resonance versus M-mode echocardiography, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 24, Pages: 59-65, ISSN: 1010-7940
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- Citations: 29
Rajappan K, O'Connell C, Sheridan DJ, 2003, Changes in QT interval with exercise in elite male rowers and controls, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 87, Pages: 217-222, ISSN: 0167-5273
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- Citations: 19
Rajappan K, Rimoldi O, Camici PG, et al., 2002, Factors influencing coronary microcirculatory function in patients with aortic stenosis after aortic valve replacement, American-Heart-Association Abstracts From Scientific Sessions, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 640-641, ISSN: 0009-7322
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- Citations: 7
Gray RP, Sheridan DJ, Fry CH, 2002, Intracellular Ca<SUP>2+</SUP> regulation in isolated myocytes from guinea-pigs with left ventricular hypertrophy induced by constriction of the thoracic aorta, Meeting of the Physiological-Society, Publisher: WILEY-BLACKWELL, Pages: 56P-56P, ISSN: 0022-3751
Fry CH, Sheridan DJ, Gray RP, 2002, Intracellular pH, H<SUP>+</SUP> buffering capacity and H<SUP>+</SUP> extrusion in isolated myocytes from guinea-pigs with left ventricular hypertrophy induced by thoracic-aortic constriction, Meeting of the Physiological-Society, Publisher: WILEY-BLACKWELL, Pages: 52P-52P, ISSN: 0022-3751
Christofi FM, Kingsbury MP, Fuller S, et al., 2002, Remodelling of the pulmonary vasculature during the evolution of chronic heart failure is associated with early upregulation and late downregulation of the angiotensin II type 1 receptor, 7th Annual Meeting of the European-Council-for-Blood-Pressure-and-Cardiovascular-Research, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 577-577, ISSN: 0194-911X
Theofanidi E, Kingsbury M, Sheridan D, 2002, Up-regulation of pulmonary preproendothelin-1 in a guinea-pig model of chronic heart failure prior to the development of pulmonary remodelling, 7th Annual Meeting of the European-Council-for-Blood-Pressure-and-Cardiovascular-Research, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 577-577, ISSN: 0194-911X
Hussain W, Patel PM, Carey P, et al., 2002, Changes in anisotropy associated with cellular architecture, and connexin43 expression in a guinea-pig model of left ventricular hypertrophy, 24th Annual Scientific Meeting of the European-Society-of-Cardiology, Publisher: OXFORD UNIV PRESS, Pages: 671-671, ISSN: 0195-668X
Kingsbury M, Mahnke A, Turner M, et al., 2002, Recovery of coronary function and morphology during regression of left ventricular hypertrophy, CARDIOVASCULAR RESEARCH, Vol: 55, Pages: 83-96, ISSN: 0008-6363
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- Citations: 4
Bakhai A, Sheridan DJ, Coutelle C, 2002, Bronchial artery delivery of viral vectors for gene delivery in cystic fibrosis; superior to airway delivery?, BMC Pulmonary Medicine, Vol: 2, ISSN: 1471-2466
BackgroundAttempts at gene therapy for the pulmonary manifestations of Cystic Fibrosis have relied mainly on airway delivery. However the efficiency of gene transfer and expression in the airway epithelia has not reached therapeutic levels. Access to epithelial cells is not homogenous for a number of reasons and the submucosal glands cannot be reached via the airways.PresentationWe propose to inject gene delivery vectors directly into bronchial arteries combined with pre-delivery of vascular endothelial growth factor to increase vascular endothelial permeability and post-delivery flow reduction by balloon occlusion. Thus it may be possible to reach mucous secreting cells of the bronchial luminal epithelium and the submucosal glands in an increased and homogenous fashion.TestingThis combination of techniques to the best of our knowledge has not previously been investigated, and may enable us to overcome some of the current limitations to gene therapy for Cystic Fibrosis.
El-Gendi H, Violaris AG, Foale R, et al., 2002, Endogenous, local, vascular endothelial growth factor production in patients with chronic total coronary artery occlusions: further evidence for its role in angiogenesis., Heart, Vol: 87, Pages: 158-159
Rajappan K, Rimoldi OE, Dutka DP, et al., 2002, Mechanisms of coronary microcirculatory dysfunction in patients with aortic stenosis and angiographically normal coronary arteries, CIRCULATION, Vol: 105, Pages: 470-476, ISSN: 0009-7322
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- Citations: 235
Fry CH, Gray RP, Sheridan DJ, 2001, Discontinuous action potential propagation in hypertrophied left ventricular guinea-pig myocardium, Scientific Meeting of the Physiological-Society, Publisher: WILEY-BLACKWELL, Pages: 79P-80P, ISSN: 0022-3751
Rajappan V, Rimoldi O, Ariff B, et al., 2001, Impairment of coronary microcirculation in aortic stenosis is related to aortic valve area, CIRCULATION, Vol: 104, Pages: 360-360, ISSN: 0009-7322
Rajappan K, Rimoldi O, Bellenger NG, et al., 2001, Functional changes in coronary microcirculation with regression of LVH, CIRCULATION, Vol: 104, Pages: 113-113, ISSN: 0009-7322
McGoldrick RB, Kingsbury MP, Turner MA, et al., 2001, Effect of heart failure induced by aortic banding in guinea pigs on vasodilation of coronary and mesenteric small arteries in vitro., HYPERTENSION, Vol: 38, Pages: 970-970, ISSN: 0194-911X
Rajappan K, Rimoldi O, Sheridan DJ, et al., 2001, A study of transmural blood flow in patients with aortic stenosis using positron emission tomography, EUROPEAN HEART JOURNAL, Vol: 22, Pages: 574-+, ISSN: 0195-668X
Rajappan K, Rimoldi O, Ariff B, et al., 2001, Coronary microcirculatory dysfunction is related to the severity of aortic stenosis, EUROPEAN HEART JOURNAL, Vol: 22, Pages: 309-309, ISSN: 0195-668X
Rajappan K, Rimoldi O, Pennell DJ, et al., 2001, Regression of LVH and changes in coronary microcirculation after valve replacement in aortic stenosis, EUROPEAN HEART JOURNAL, Vol: 22, Pages: 95-95, ISSN: 0195-668X
Stavrou BM, Sheridan DJ, Flores NA, 2001, Contribution of nitric oxide and prostanoids to the cardiac electrophysiological and coronary vasomotor effects of diadenosine polyphosphates, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 298, Pages: 531-538, ISSN: 0022-3565
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- Citations: 13
Carey PA, Turner M, Fry CH, et al., 2001, Reduced anisotropy of action potential conduction in left ventricular hypertrophy, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Vol: 12, Pages: 830-835, ISSN: 1045-3873
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- Citations: 17
Kingsbury MP, Huang W, Turner MA, et al., 2001, Resistance to pulmonary oedema in anaesthetised guinea-pigs with chronic heart failure, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 533, Pages: 90P-90P, ISSN: 0022-3751
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- Citations: 1
Stavrou BM, Lawrence C, Blackburn GM, et al., 2001, Coronary vasomotor and cardiac electrophysiologic effects of diadenosine polyphosphates and nonhydrolyzable analogs in the guinea pig, JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, Vol: 37, Pages: 571-584, ISSN: 0160-2446
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- Citations: 8
Wallis W, Cooklin M, Sheridan DJ, et al., 2001, The action of isoprenaline on the electrophysiological properties of hypertrophied left ventricular myocytes., Arch Physiol Biochem, Vol: 109, Pages: 117-126, ISSN: 1381-3455
The electrophysiological effects of the beta-agonist, isoprenaline, on hypertrophied left ventricular myocardium were measured to understand better the arrhythmic effects of beta-stimulation on the hypertrophied heart. Left ventricular hypertrophy was induced in guinea-pigs by constriction of the thoracic aorta. An age-matched sham-operated group served as controls. Isolated myocytes were held under voltage- and current clamp and the effect of isoprenaline on the L-type Ca2+ current, I(Ca), a Cl- current, I(Cl), and action potential morphology were measured. Cardiac growth was mirrored by cellular hypertrophy. I(Ca) and I(Cl) current density were reduced as myocyte hypertrophy progressed. The augmentation of I(Ca) and I(Cl) by isoprenaline was also reduced in hypertrophy, but no other characteristics of the two currents, or the dose-dependency of the action of isoprenaline were a function of cardiac growth. Isoprenaline prolonged the action potential, but to a smaller extent in hypertrophied myocytes. This difference in action potential prolongation was abolished by glibenclamide. The changes to I(Ca) and I(Cl) in hypertrophy would not tend to increase triggered activity in this situation. Under maximum inotropic stimulation hypertrophied myocytes show action potential changes which are consistent with intracellular ATP depletion, and which could enhance the likelihood of re-entrant circuits. A simple diffusion model for oxygen is constructed to demonstrate the possibility of cellular hypoxia in hypertrophied myocytes.
Morris-Jones R, Staughton RC, Walker M, et al., 2001, Lichen myxoedematosus with associated cardiac abnormalities., Br J Dermatol, Vol: 144, Pages: 594-596, ISSN: 0007-0963
We describe a 42-year-old woman who developed lichen myxoedematosus. Twenty years after the onset of the disease she became breathless and hypertensive, and an echocardiogram showed a mass on the mitral valve, which was thought to be a mucin deposit. Her hypertension was resistant to treatment with combination antihypertensives. To our knowledge, this is the first report to link lichen myxoedematosus with a valvular mucinous mass. This case also demonstrates the slow clinical progression of the disease over 20 years.
Kingsbury MP, Robinson H, Flores NA, et al., 2001, Investigation of mechanisms that mediate reactive hyperaemia in guinea-pig hearts:: role of K<sub>ATP</sub> channels, adenosine, nitric oxide and prostaglandins, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 132, Pages: 1209-1216, ISSN: 0007-1188
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- Citations: 16
Rajappan K, Rimoldi O, Schafers KP, et al., 2001, Evidence of stress-induced subendocardial hypoperfusion in patients with aortic stenosis demonstrated by positron emission tomography, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 37, Pages: 419A-420A, ISSN: 0735-1097
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- Citations: 1
Rajappan K, Mayet J, Rimoldi O, et al., 2001, ECG changes and microcirculatory dysfunction in aortic valve stenosis, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 37, Pages: 482A-482A, ISSN: 0735-1097
Huang WX, Kingsbury MP, Turner MA, et al., 2001, Capillary filtration is reduced in lungs adapted to chronic heart failure: morphological and haemodynamic correlates, CARDIOVASCULAR RESEARCH, Vol: 49, Pages: 207-217, ISSN: 0008-6363
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- Citations: 66
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