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Sanger GJ, Tuladhar BR, Brown J, et al., 2007, Modulation of peristalsis by NK<sub>3</sub> receptor antagonism in guinea‐pig isolated ileum is revealed as intraluminal pressure is raised, Autonomic and Autacoid Pharmacology, Vol: 27, Pages: 105-111, ISSN: 1474-8665
<jats:title>Summary</jats:title><jats:p> <jats:bold>1</jats:bold> NK<jats:sub>3</jats:sub> tachykinin receptors mediate slow excitatory transmission in the enteric nervous system and play a role in reflexes induced by the intestinal stretch or mucosal compression. However, there is little evidence to suggest that these receptors are important in peristalsis. We have examined the effects of the NK<jats:sub>3</jats:sub> receptor antagonist, talnetant, on peristalsis in guinea‐pig isolated ileum induced by optimal and by supra‐maximal distension pressures. <jats:bold>2</jats:bold> At the guinea‐pig NK<jats:sub>3</jats:sub> receptor, talnetant was shown to have high affinity (p<jats:italic>K</jats:italic><jats:sub>B</jats:sub> 8.8) and selectivity over the guinea‐pig NK<jats:sub>1</jats:sub> and NK<jats:sub>2</jats:sub> receptors. <jats:bold>3</jats:bold> Peristaltic waves in the ileum elicited by optimal distension pressures (1–3 cmH<jats:sub>2</jats:sub>O) were unaffected by talnetant at a supra‐maximal concentration (250 n<jats:sc>m</jats:sc>). <jats:bold>4</jats:bold> Distension at a higher pressure (4 cmH<jats:sub>2</jats:sub>O) induced peristalsis in which there was incomplete closure of the lumen during each peristaltic wave and an increase in the periods of inactivity observed between bursts of peristaltic activity. The addition of talnetant (250 n<jats:sc>m</jats:sc>) increased the number of peristaltic events by reducing these periods of inactivity and thus, increased the productivity of the peristaltic reflex. <jats:bold>5</jats:bold> The data suggest that NK<jats:sub>3</jats:sub> receptors are not involved in the modulation of peristaltic movements by physiological stimuli, but they may hav
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