Imperial College London
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DrDineshSivakumar

Faculty of Medicine, School of Public Health

Senior Data Specialist
 
 
 
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Contact

 

+44 (0)20 7594 2671d.sivakumar

 
 
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Location

 

Stadium HouseWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sanger:2007:10.1111/j.1474-8673.2007.00396.x,
author = {Sanger, GJ and Tuladhar, BR and Brown, J and Aziz, E and Sivakumar, D and Furness, JB},
doi = {10.1111/j.1474-8673.2007.00396.x},
journal = {Autonomic and Autacoid Pharmacology},
pages = {105--111},
title = {Modulation of peristalsis by NK<sub>3</sub> receptor antagonism in guineapig isolated ileum is revealed as intraluminal pressure is raised},
url = {http://dx.doi.org/10.1111/j.1474-8673.2007.00396.x},
volume = {27},
year = {2007}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Summary</jats:title><jats:p> <jats:bold>1</jats:bold> NK<jats:sub>3</jats:sub> tachykinin receptors mediate slow excitatory transmission in the enteric nervous system and play a role in reflexes induced by the intestinal stretch or mucosal compression. However, there is little evidence to suggest that these receptors are important in peristalsis. We have examined the effects of the NK<jats:sub>3</jats:sub> receptor antagonist, talnetant, on peristalsis in guineapig isolated ileum induced by optimal and by supramaximal distension pressures.<jats:bold>2</jats:bold> At the guineapig NK<jats:sub>3</jats:sub> receptor, talnetant was shown to have high affinity (p<jats:italic>K</jats:italic><jats:sub>B</jats:sub> 8.8) and selectivity over the guineapig NK<jats:sub>1</jats:sub> and NK<jats:sub>2</jats:sub> receptors.<jats:bold>3</jats:bold> Peristaltic waves in the ileum elicited by optimal distension pressures (1–3 cmH<jats:sub>2</jats:sub>O) were unaffected by talnetant at a supramaximal concentration (250 n<jats:sc>m</jats:sc>).<jats:bold>4</jats:bold> Distension at a higher pressure (4 cmH<jats:sub>2</jats:sub>O) induced peristalsis in which there was incomplete closure of the lumen during each peristaltic wave and an increase in the periods of inactivity observed between bursts of peristaltic activity. The addition of talnetant (250 n<jats:sc>m</jats:sc>) increased the number of peristaltic events by reducing these periods of inactivity and thus, increased the productivity of the peristaltic reflex.<jats:bold>5</jats:bold> The data suggest that NK<jats:sub>3</jats:sub> receptors are not involved in the modulation of peristaltic movements by physiological stimuli, but they may hav
AU  - Sanger,GJ
AU  - Tuladhar,BR
AU  - Brown,J
AU  - Aziz,E
AU  - Sivakumar,D
AU  - Furness,JB
DO  - 10.1111/j.1474-8673.2007.00396.x
EP  - 111
PY  - 2007///
SN  - 1474-8665
SP  - 105
TI  - Modulation of peristalsis by NK<sub>3</sub> receptor antagonism in guineapig isolated ileum is revealed as intraluminal pressure is raised
T2  - Autonomic and Autacoid Pharmacology
UR  - http://dx.doi.org/10.1111/j.1474-8673.2007.00396.x
VL  - 27
ER  -
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