14 results found
Schmitt A, Sory D, Tappert L, et al., 2020, Dynamic characterisation of the temporomandibular joint disc using split Hopkinson pressure bars, Computer Methods in Biomechanics and Biomedical Engineering, Vol: 23, Pages: S273-S275, ISSN: 1025-5842
Sory DR, Amin HD, Chapman D, et al., 2020, Replicating landmine blast loading in cellular <i>in Vitro</i> models, Physical Biology, Vol: 17, ISSN: 1478-3967
Trauma arising from landmines and improvised explosive devices promotes heterotopic ossification, the formation of extra-skeletal bone in non-osseous tissue. To date, experimental platforms that can replicate the loading parameter space relevant to improvised explosive device and landmine blast wave exposure have not been available to study the effects of such non-physiological mechanical loading on cells. Here, we present the design and calibration of three distinct in vitro experimental loading platforms that allow us to replicate the spectrum of loading conditions recorded in near-field blast wave exposure. We subjected cells in suspension or in a three-dimensional hydrogel to strain rates up to 6000 s-1and pressure levels up to 45 MPa. Our results highlight that cellular activation is regulated in a non-linear fashion - not by a single mechanical parameter, it is the combined action of the applied mechanical pressure, rate of loading and loading impulse, along with the extracellular environment used to convey the pressure waves. Finally, our research indicates that PO MSCs are finely tuned to respond to mechanical stimuli that fall within defined ranges of loading.
Lee JJ, Sory DR, Proud WG, 2020, Simulation of Two-gauge Measurement Method on the SHPB for Testing Soft Materials, 21st Biennial American-Physical-Society -Topical-Group Conference on Shock Compression of Condensed Matter (SCCM), Publisher: AMER INST PHYSICS, ISSN: 0094-243X
Proud WG, Martin E, Tear GR, et al., 2020, The Effect of Temperature on the Failure of a Simple Perspex Structure, 21st Biennial American-Physical-Society -Topical-Group Conference on Shock Compression of Condensed Matter (SCCM), Publisher: AMER INST PHYSICS, ISSN: 0094-243X
Magnus D, Sory DR, Lee J, et al., 2020, Study of Soft Material Blast Mitigation Effects Using a Shock Tube, 21st Biennial American-Physical-Society -Topical-Group Conference on Shock Compression of Condensed Matter (SCCM), Publisher: AMER INST PHYSICS, ISSN: 0094-243X
Injuries sustained due to attacks from explosive weapons are multiple in number, complex in nature, and not well characterised. Blast may cause damage to the human body by the direct effect of overpressure, penetration by highly energised fragments, and blunt trauma by violent displacements of the body. The ability to reproduce the injuries of such insults in a well-controlled fashion is essential in order to understand fully the unique mechanism by which they occur, and design better treatment and protection strategies to alleviate the resulting poor long-term outcomes. This paper reports a range of experimental platforms that have been developed for different blast injury models, their working mechanism, and main applications. These platforms include the shock tube, split-Hopkinson bars, the gas gun, drop towers and bespoke underbody blast simulators.
Sory DR, Amin HD, Rankin SM, et al., 2018, Osteogenic Differentiation of Periosteum-Derived Stromal Cells in Blast-Associated Traumatic Loading, 20th Biennial Conference of the Topical-Group of the American-Physical-Society (APS) on Shock Compression of Condensed Matter (SCCM), Publisher: AMER INST PHYSICS, ISSN: 0094-243X
Brown KA, Butler BJ, Sory D, et al., 2018, Challenges in the Characterization of Failure and Resilience of Biological Materials, 20th Biennial Conference of the Topical-Group of the American-Physical-Society (APS) on Shock Compression of Condensed Matter (SCCM), Publisher: AMER INST PHYSICS, ISSN: 0094-243X
Tear G, Cohen A, Magnus D, et al., 2018, Damage characterisation for cement and concrete using microwave induced damage, International Conference on Experimental Mechanics, Publisher: MDPI, ISSN: 2504-3900
Damage leading to failure in concrete and related materials is a complex behavior. Whilst many numerical approaches are available for simulating the degradation of material strength, it is difficult to discriminate between these models experimentally in the high strain rate ballistic impact regime. An experimental method has been developed to determine when local material failure has occurred, and whether the failure can be classed as fracture or granular flow. This method is tested on Kolsky bar and ballistic impact experiments. Comparison with numerical simulations is presented.
Nguyen TN, Sory DR, Rankin SM, et al., 2018, Platform development for primary blast injury studies, Trauma (United Kingdom), ISSN: 1460-4086
© 2018, The Author(s) 2018. Explosion-related injuries are currently the most commonly occurring wounds in modern conflicts. They are observed in both military and civilian theatres, with complex injury pathophysiologies. Primary blast injuries are the most frequently encountered critical injuries experienced by victims close to the explosion. They are caused by large and rapid pressure changes of the blast waves which produce a wide range of loading patterns resulting in varied injuries. Well-characterised experimental loading devices which can reproduce the real mechanical characteristics of blast loadings on biological specimens in in vivo, ex vivo, and in vitro models are essential in determining the injury mechanisms. This paper discusses the performance and application of platforms, including shock tubes, mechanical testing machines, drop-weight rigs, and split-Hopkinson pressure bar, with regards to the replication of primary blast.
Jung A, Luksch J, Felten M, et al., 2017, Investigation of strain-rate effects in Al foams and Ni/Al hybrid foams on different scales, PAMM, Vol: 17, Pages: 317-318, ISSN: 1617-7061
Sory DR, Areias AC, Overby DR, et al., 2017, Novel method to dynamically load cells in 3D-hydrogels culture for blast injury studies, 19th Biennial American-Physical-Society (APS) Conference on Shock Compression of Condensed Matter (SCCM), Publisher: AMER INST PHYSICS, ISSN: 0094-243X
Butler BJ, Sory DR, Nguyen T-TN, et al., 2017, Characterization of Focal Muscle Compression Under Impact Loading, 19th Biennial American-Physical-Society (APS) Conference on Shock Compression of Condensed Matter (SCCM), Publisher: AMER INST PHYSICS, ISSN: 0094-243X
Rittel D, Rotbaum Y, Rodriguez-Martinez JA, et al., 2014, Dynamic Necking of Notched Tensile Bars: An Experimental Study, EXPERIMENTAL MECHANICS, Vol: 54, Pages: 1099-1109, ISSN: 0014-4851
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