Imperial College London


Faculty of MedicineDepartment of Surgery & Cancer

Clinical Senior Lecturer in Hepato-Biliary Surgery



+44 (0)20 3313 3941d.spalding




Hammersmith HospitalHammersmith Campus






Clinical Senior Lecturer and Honorary Consultant in Hepatobiliary and Pancreatic Surgery. Has a clinical interest in HPB Surgery with a specific focus on minimally invasive techniques, the use of radiofrequency energy as a resection tool, cholangiocarcinomas and neuroendocrine tumours.



  • BSc in Biochemistry, University of Southampton, 1985
  • MB ChB, University of Birmingham, 1989
  • FRCS (Eng), 1993
  • FRCS (Gen Surg), 2002
  • MD, University of London, 2006

 Research Interests

  • Molecular pathogenesis of cholangiocarcinomas to identify novel therapeutic targets.
  • Early detection of cholangiocarcinomas using novel biomarkers
  • Synthesis of novel molecular conjugates comprising chemotherapeutic agents and transporter molecules for targeted delivery to cholangiocarcinomas.
  • Stellate cancer-associated fibroblasts contribution to chemoresistance of pancreatic ductal adenocarcinoma.

Membership of Professional Bodies

  • Association of Surgeons of Great Britain and Ireland
  • Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland
  • Fellow of the Royal College of Surgeons of England
  • International Hepatopancreatobiliary Association
  • Royal Society of Medicine
  • British Medical Association

 Teaching Activities

Undergraduate Teaching

  • Module leader BSc in Surgery and Anaesthesia (Module 1: Regeneration, repair and cancer control).
  • BSc in Gastroenterology and Hepatology

  Postgraduate Teaching

  • MSc in Surgical Science
  • MSc in Surgical Technology

 Invited Teaching

  • Whipps Cross Higher Surgery Course

  Postgraduate Supervision

  • Supervising 2 PhD, 2 MSc and 1 MRes Projects  

 Editorial Boards  

  • Sub-editor of the Journal of HPB Surgery 



Gavriilidis P, Sutcliffe RP, Roberts KJ, et al., 2020, No difference in mortality among ALPPS, two-staged hepatectomy, and portal vein embolization/ligation: A systematic review by updated traditional and network meta-analyses., Hepatobiliary Pancreat Dis Int, Vol:19, ISSN:1499-3872, Pages:411-419

Sarker D, Plummer R, Meyer T, et al., 2020, MTL-CEBPA, a small activating RNA therapeutic upregulating C/EBP-α, in patients with advanced liver cancer: a first-in-human, multicenter, open-label, phase I trial, Clinical Cancer Research, Vol:26, ISSN:1078-0432, Pages:3936-3946

da Costa AC, Sodergren M, Jayant K, et al., 2020, Radiofrequency combined with immunomodulation for hepatocellular carcinoma: State of the art and innovations, World Journal of Gastroenterology, Vol:26, ISSN:1007-9327, Pages:2040-2048


Noor MS, Dennis J, Al-Hinai K, et al., 2020, Quality Improvement Project: Improving the External Referrals Service of the Hepato-Pancreato-Biliary (HPB) Surgery in a Tertiary Centre, International Surgical Conference of the Association-of-Surgeons-in-Training, WILEY, Pages:187-187, ISSN:0007-1323

Sarker D, Sodergren M, Plummer ER, et al., 2020, Phase Ib dose escalation and cohort expansion study of the novel myeloid differentiating agent MTL-CEBPA in combination with sorafenib in patients with advanced hepatocellular carcinoma (HCC)., AMER SOC CLINICAL ONCOLOGY, ISSN:0732-183X

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