Imperial College London


Faculty of MedicineDepartment of Surgery & Cancer

Clinical Senior Lecturer in Hepato-Biliary Surgery



+44 (0)20 3313 3941d.spalding




Hammersmith HospitalHammersmith Campus






Clinical Senior Lecturer and Honorary Consultant in Hepatobiliary and Pancreatic Surgery. Has a clinical interest in HPB Surgery with a specific focus on minimally invasive techniques, the use of radiofrequency energy as a resection tool, cholangiocarcinomas and neuroendocrine tumours.



  • BSc in Biochemistry, University of Southampton, 1985
  • MB ChB, University of Birmingham, 1989
  • FRCS (Eng), 1993
  • FRCS (Gen Surg), 2002
  • MD, University of London, 2006

 Research Interests

  • Molecular pathogenesis of cholangiocarcinomas to identify novel therapeutic targets.
  • Early detection of cholangiocarcinomas using novel biomarkers
  • Synthesis of novel molecular conjugates comprising chemotherapeutic agents and transporter molecules for targeted delivery to cholangiocarcinomas.
  • Stellate cancer-associated fibroblasts contribution to chemoresistance of pancreatic ductal adenocarcinoma.

Membership of Professional Bodies

  • Association of Surgeons of Great Britain and Ireland
  • Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland
  • Fellow of the Royal College of Surgeons of England
  • International Hepatopancreatobiliary Association
  • Royal Society of Medicine
  • British Medical Association

 Teaching Activities

Undergraduate Teaching

  • Module leader BSc in Surgery and Anaesthesia (Module 1: Regeneration, repair and cancer control).
  • BSc in Gastroenterology and Hepatology

  Postgraduate Teaching

  • MSc in Surgical Science
  • MSc in Surgical Technology

 Invited Teaching

  • Whipps Cross Higher Surgery Course

  Postgraduate Supervision

  • Supervising 2 PhD, 2 MSc and 1 MRes Projects  

 Editorial Boards  

  • Sub-editor of the Journal of HPB Surgery 



Avari P, Eng PC, Hu M, et al., 2023, A novel somatic mutation implicates ATP6V0D1 in proinsulin processing, Journal of the Endocrine Society, Vol:7, ISSN:2472-1972, Pages:1-5

Das B, Fehervari M, Hamrang-Yousefi S, et al., 2022, Pancreaticoduodenectomy with right hemicolectomy for advanced malignancy: a single UK hepatopancreaticobiliary centre experience, Colorectal Disease, ISSN:1462-8910

Alghazawi LOK, Entwistle OH, Fehervari M, et al., 2022, Unusual cause of intraoperative haemorrhage: a lesson for patient counselling, Bmj Case Reports, Vol:15


D'Alessio A, Pai M, Spalding D, et al., 2022, PRIME-HCC: phase Ib study of neoadjuvant ipilimumab and nivolumab prior to liver resection for hepatocellular carcinoma, International Liver Congress, ELSEVIER, Pages:S108-S109, ISSN:0168-8278

D'Alessio A, Pai M, Spalding D, et al., 2022, Preliminary results from a phase Ib study of neoadjuvant ipilimumab plus nivolumab prior to liver resection for hepatocellular carcinoma: The PRIME-HCC trial., LIPPINCOTT WILLIAMS & WILKINS, ISSN:0732-183X

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