Publications
126 results found
Reebye V, Saetrom P, Mintz PJ, et al., 2014, A Novel RNA Oligonucleotide Improves Liver Function and Inhibits Liver Carcinogenesis In Vivo, HEPATOLOGY, Vol: 59, Pages: 216-227, ISSN: 0270-9139
Mintz PJ, Huang K-W, Reebye V, et al., 2014, Exploiting human CD34(+) stem cell-conditioned medium for tissue repair, Molecular Therapy, Vol: 22, Pages: 149-159, ISSN: 1525-0016
Despite the progress in our understanding of genes essential for stem cell regulation and development, little is known about the factors secreted by stem cells and their effect on tissue regeneration. In particular, the factors secreted by human CD34+ cells remain to be elucidated. We have approached this challenge by performing a cytokine/growth factor microarray analysis of secreted soluble factors in medium conditioned by adherent human CD34+ cells. Thirty-two abundantly secreted factors have been identified, all of which are associated with cell proliferation, survival, tissue repair, and wound healing. The cultured CD34+ cells expressed known stem cell genes such as Nanog, Oct4, Sox2, c-kit, and HoxB4. The conditioned medium containing the secreted factors prevented cell death in liver cells exposed to liver toxin in vitro via inhibition of the caspase-3 signaling pathway. More importantly, in vivo studies using animal models of liver damage demonstrated that injection of the conditioned medium could repair damaged liver tissue (significant reduction in the necroinflammatory activity), as well as enable the animals to survive. Thus, we demonstrate that medium conditioned by human CD34+ cells has the potential for therapeutic repair of damaged tissue in vivo.
Huang KW, Reebye V, Mintz PJ, et al., 2013, Short activating RNA (saRNA) targeting C/EBPA significantly inhibits cell proliferation of undifferentiated cancer cells., MOLECULAR CANCER THERAPEUTICS, Vol: 12, ISSN: 1535-7163
Johnson N, Spalding D, Lord C, 2013, Profiling chemoresistance in pancreatic ductal adenocarcinoma and the stromal microenvironment stellate cancer-associated fibroblast., Int J Surg, Vol: 11
Hunter D, Shrestha A, Spalding D, et al., 2013, BASO∼The association of cancer surgery prize winner: Determining complete clinical response of radiologically disappearing colorectal liver metastases after chemotherapy and how they should be managed., Int J Surg, Vol: 11
Shrestha AK, Pai M, Jiao LR, et al., 2013, Resection margin status and long-term outcome using radiofrequency energy as a resection tool for colorectal liver metastases, International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI), Publisher: WILEY-BLACKWELL, Pages: 128-129, ISSN: 0007-1323
Skouras C, Skouras T, Pai M, et al., 2013, Inguinoscrotal extension of a pancreatic collection: a rare complication of pancreatitis-case report and review of the literature., Updates Surg, Vol: 65, Pages: 153-159, ISSN: 2038-131X
Pancreatitis associated with the extension of a pancreatic collection, pseudocyst or abscess into the groin is a rare phenomenon with few reports in the English literature. Nevertheless, it remains a clinically important differential diagnosis as it may be mistaken for more common pathologies in the groin and with a subsequent unnecessary surgical intervention. A case of this rare complication of pancreatitis is reported, together with a review of the literature.
Dina R, Tran-Dang M-A, Mauri F, et al., 2013, Pancreatobiliary cytology in the multidisciplinary setting, CYTOPATHOLOGY, Vol: 24, Pages: 150-158, ISSN: 0956-5507
- Author Web Link
- Cite
- Citations: 6
Drymousis P, Pai M, Spalding D, et al., 2013, Is octreotide beneficial in patients undergoing pancreaticoduodenectomy? Best evidence topic (BET), INTERNATIONAL JOURNAL OF SURGERY, Vol: 11, Pages: 779-782, ISSN: 1743-9191
- Author Web Link
- Cite
- Citations: 8
Zhang Y, Frampton AE, Cohen P, et al., 2012, Tumor infiltration in the medial resection margin predicts survival after pancreaticoduodenectomy for pancreatic ductal adenocarcinoma., Journal of Gastrointestinal Surgery, Vol: 16, Pages: 1875-1882
Zhang Y, Frampton AE, Cohen P, et al., 2012, Tumor Infiltration in the Medial Resection Margin Predicts Survival After Pancreaticoduodenectomy for Pancreatic Ductal Adenocarcinoma, JOURNAL OF GASTROINTESTINAL SURGERY, Vol: 16, Pages: 1875-1882, ISSN: 1091-255X
- Author Web Link
- Cite
- Citations: 47
Frampton AE, Pai M, Krell J, et al., 2012, The "malignant truth" about the recurrence of pancreatic intraductal papillary mucinous neoplasms., Archives of Surgery, Vol: 147, Pages: 977-979
Pai M, Frampton AE, Mikhail S, et al., 2012, Radiofrequency assisted liver resection: Analysis of 604 consecutive cases., Eur J Surg Oncol., Vol: 38, Pages: 274-280
Martin JL, Tedeschi M, Jackson JE, et al., 2012, Primary lymph node gastrinoma or metastatic gastrinoma with unidentified primary tumor site?, World Journal of Endocrine Surgery, Vol: 4, Pages: 66-70, ISSN: 0975-5039
Gastrinomas are neuroendocrine tumors that secrete gastrin and result in a clinical syndrome of peptic ulcer disease first described by Zollinger and Ellison in 1955.1 They present either sporadically or as a component of a hereditary determined syndrome, multiple endocrine neoplasia type 1. They are usually located in the pancreas and duodenum but have been reported to occur in both abdominal and extraabdominal sites.2 Reports of clinical and biochemical cure following resection of lymph nodes found to contain gastrinomas, in patients without a localized primary tumor, led investigators to cite the existence of the primary lymph node gastrinoma. Whether these cases represent metastatic disease from an, as yet, unidentified primary tumor, or de novo occurrence of a gastrinoma in a lymph node remains controversial. While some authors report that primary lymph node gastrinomas account for up to 10% of sporadic gastrinomas3,4 others question this theory, hypothesizing that their presentation represents an undetected microgastrinoma with metastatic lymph node involvement.5 Herewith, we report on a patient with Zollinger-Ellison syndrome in whom a peripancreatic lymph node with evidence of gastrinoma is the only apparent morphologic manifestation of the disease.
Pai M, Spalding D, Jiao L, et al., 2012, Use of Bipolar Radiofrequency in Parenchymal Transection of the Liver, Pancreas and Kidney, DIGESTIVE SURGERY, Vol: 29, Pages: 43-47, ISSN: 0253-4886
- Author Web Link
- Cite
- Citations: 21
Williamson J, Williamson R, Spalding D, 2012, Non-functioning neuroendocrine tumours of the pancreas: a surgical challenge, International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI), Publisher: WILEY-BLACKWELL, Pages: 91-91, ISSN: 0007-1323
Qiu S, Vaughan-Huxley E, Mikhail S, et al., 2012, Aetiology and management of spontaneous liver haemorrhage, International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI), Publisher: WILEY-BLACKWELL, Pages: 150-150, ISSN: 0007-1323
Kayani B, Spalding DR, Jiao LR, et al., 2012, Does neostigmine improve time to resolution of symptoms in acute colonic pseudo-obstruction?, INTERNATIONAL JOURNAL OF SURGERY, Vol: 10, Pages: 453-457, ISSN: 1743-9191
- Author Web Link
- Cite
- Citations: 16
Fovos A, Jarral O, Patel V, et al., 2012, Does Heller's myotomy provide superior clinical outcome in comparison to botulinum toxin injection for treatment of achalasia? Best evidence topic (BET), INTERNATIONAL JOURNAL OF SURGERY, Vol: 10, Pages: 120-123, ISSN: 1743-9191
- Author Web Link
- Cite
- Citations: 8
Pai M, Spalding D, Xi F, et al., 2012, Autologous Bone Marrow Stem Cells in the Treatment of Chronic Liver Disease, International Journal of Hepatology, Vol: 2012
Bhuva N, Wasan H, Spalding D, et al., 2011, Intraductal tubulopapillary neoplasm of the pancreas as a radiation induced malignancy., BMJ Case Rep, Vol: 2011
Pancreatic malignancies account for 3% of all cancer diagnoses in the UK and prognosis is poor with overall 1-year survival rates at 20% and 5-year survival rates at 5%. The majority of these cancers (75%-95%) arise from the exocrine part of the gland and are almost all invasive ductal adenocarcinomas. One per cent of all pancreatic tumours are endocrine tumours. There is limited data regarding the management of such rare neoplasms of the pancreas and some evidence suggests that prognoses and risk factors may be different. Therefore, it is important to report experience of this type of malignancy in order to build a knowledge base to guide the practice of future clinicians. The authors report a case of an intraductal tubulopapillary neoplasm of the pancreas. This is very unusual form of intraductal pancreatic tumour, which is now thought to occupy a distinct histological subcategory and has arisen within a previously irradiated field.
Pai M, Kyriakides C, Mikhail S, et al., 2011, Radiofrequency-Assisted Hepatic Resection, ANNALS OF SURGICAL ONCOLOGY, Vol: 18, Pages: 3391-3391, ISSN: 1068-9265
- Author Web Link
- Cite
- Citations: 6
Mckay SC, Unger K, Pericleous S, et al., 2011, A FOUR MICRORNA SIGNATURE CORRELATES WITH IMPROVED SURVIVAL IN CHOLANGIOCARCINOMA, 62nd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), Publisher: WILEY-BLACKWELL, Pages: 1290A-1290A, ISSN: 0270-9139
Mckay SC, Unger K, Hess J, et al., 2011, COPY NUMBER GAIN AT CHROMOSOME 8Q21-24.3 CORRELATES WITH POOR SURVIVAL IN CHOLANGIOCARCINOMA, 62nd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), Publisher: WILEY-BLACKWELL, Pages: 1289A-1289A, ISSN: 0270-9139
Mckay SC, Unger K, Pericleous S, et al., 2011, MICRORNA PROFILING REVEALS KEY MICRORNAS AND MOLECULAR PATHWAYS INVOLVED IN BILIARY TRACT CANCER, 62nd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), Publisher: WILEY-BLACKWELL, Pages: 1292A-1293A, ISSN: 0270-9139
Feng X, Pai M, Mizandari M, et al., 2011, Towards the optimization of management of hepatocellular carcinoma., Front Med, Vol: 5, Pages: 271-276
Hepatocellular carcinoma (HCC) is the fifth most common neoplasm in the world, closely correlated with viral hepatitis and liver cirrhosis. The vast majority of HCC patients present at a late stage and are unsuitable for surgery due to limited liver functional reserve. Tumors can involve major vessels or hilar structures, necessitating major liver resection and/or rendering liver resection unfeasible. A series of new technologies have been developed to optimise HCC management. Stem cell therapy improves impaired liver functional reserve prior to liver resection. Intravascular radiofrequency ablation recanalises the portal vein invaded by tumour thrombus and endobiliary radiofrequency ablation restores and extends biliary patency of the bile duct invaded by malignancy. Laparoscopic radiofrequency assisted liver resection minimizes blood loss and avoids liver warm ischemia, while increasing parenchymal sparing. These benefits combined maximize the safety of liver resection.
Williamson JML, Thorn CC, Spalding D, et al., 2011, Pancreatic and peripancreatic somatostatinomas, ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND, Vol: 93, Pages: 356-360, ISSN: 0035-8843
- Author Web Link
- Cite
- Citations: 16
Mirnezami R, Kang C, Pai M, et al., 2011, Meta-analysis of survival outcomes following radiofrequency ablation (RFA) <i>versus</i> surgical resection (SR) for hepatocellular carcinoma (HCC), International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland, Publisher: WILEY-BLACKWELL, Pages: 9-9, ISSN: 0007-1323
Wadsworth CA, Dixon PH, Zabron AA, et al., 2011, GENETIC VARIATION IN NATURAL KILLER CELL RECEPTOR PROTEIN G2D DOES NOT MODIFY SUSCEPTIBILITY TO SPORADIC CHOLANGIOCARCINOMA, Annual Meeting on British-Society-of-Gasenterology, Publisher: B M J PUBLISHING GROUP, ISSN: 0017-5749
McKay SC, Unger K, Pericleous S, et al., 2011, Array comparative genomic hybridization identifies novel potential therapeutic targets in cholangiocarcinoma, HPB (Oxford), Vol: 5, Pages: 309-319
Background: Cholangiocarcinoma (CC) is a rare tumour with a dismal prognosis. As conventional medical management offers minimal survival benefit, surgery currently represents the only chance of cure. We evaluated DNA copy number (CN) alterations in CC to identify novel therapeutic targets. Methods: DNA was extracted from 32 CC samples. Bacterial artificial chromosome (BAC) array comparative genomic hybridization was performed using microarray slides containing 3400 BAC clones covering the whole human genome at distances of 1 Mb. Data were analysed within the R statistical environment. Results: DNA CN gains (89 regions) occurred more frequently than DNA CN losses (55 regions). Six regions of gain were identified in all cases on chromosomes 16, 17, 19 and 22. Twenty regions were frequently gained on chromosomes 1, 5, 7, 9, 11, 12, 16, 17, 19, 20 and 21. The BAC clones covering ERBB2, MEK2 and PDGFB genes were gained in all cases. Regions covering MTOR, VEGFR 3, PDGFA, RAF1, VEGFA and EGFR genes were frequently gained. Conclusions: We identified CN gains in the region of 11 useful molecular targets. Findings of variable gains in some regions in this and other studies support the argument for molecular stratification before treatment for CC so that treatment can be tailored to the individual patient.
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.