Imperial College London
Mr Duncan Spalding

MrDuncanSpalding

Faculty of Medicine, Department of Surgery & Cancer

Clinical Senior Lecturer in Hepato-Biliary Surgery
 
 
 
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Contact

 

+44 (0)20 3313 3941d.spalding

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wadsworth:2019:10.1016/j.jceh.2018.06.521,
author = {Wadsworth, CA and Dixon, PH and Taylor-Robinso, SD and Kim, JU and Zabron, AA and Wong, JH and Chapman, MH and McKay, SC and Spalding, DR and Wasan, HS and Pereira, SP and Thomas, HC and Whittaker, JC and Williamson, C and Khan, SA},
doi = {10.1016/j.jceh.2018.06.521},
journal = {Journal of Clinical and Experimental Hepatology},
pages = {171--175},
title = {Polymorphisms in natural killer cell receptor protein 2D (NKG2D) as a risk factor for Cholangiocarcinoma},
url = {http://dx.doi.org/10.1016/j.jceh.2018.06.521},
volume = {9},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background and aims: Understanding of the significant genetic risk factors for Cholangiocarcinoma (CC) remains limited. Polymorphisms in the natural killer cell receptor G2D (NKG2D) gene have been shown to increase risk of CC transformation in patients with Primary Sclerosing Cholangitis (PSC). We present a validation study of NKG2D polymorphisms in CC patients without PSC. Methods: Seven common Single Nucleotide Polymorphisms (SNPs) of the NKG2D gene were genotyped in 164 non-PSC related CC subjects and 257 controls with HaploView. The two SNPs that were positively identified in the previous Scandinavian study, rs11053781 and rs2617167, were included. Results: The seven genotyped SNPs were not associated with risk of CC. Furthermore, haplotype analysis revealed that there was no evidence to suggest that any haplotype differs in frequency between cases and controls (P > 0.1). Conclusion: The common genetic variation in NKG2D does not correlate significantly with sporadic CC risk. This is in contrast to the previous positive findings in the Scandinavian study with PSC-patients. The failure to reproduce the association may reflect an important difference between the pathogenesis of sporadic CC and that of PSC-related CC. Given that genetic susceptibility is likely to be multifaceted and complex, further validation studies that include both sporadic and PSC-related CC are required.
AU  - Wadsworth,CA
AU  - Dixon,PH
AU  - Taylor-Robinso,SD
AU  - Kim,JU
AU  - Zabron,AA
AU  - Wong,JH
AU  - Chapman,MH
AU  - McKay,SC
AU  - Spalding,DR
AU  - Wasan,HS
AU  - Pereira,SP
AU  - Thomas,HC
AU  - Whittaker,JC
AU  - Williamson,C
AU  - Khan,SA
DO  - 10.1016/j.jceh.2018.06.521
EP  - 175
PY  - 2019///
SN  - 0973-6883
SP  - 171
TI  - Polymorphisms in natural killer cell receptor protein 2D (NKG2D) as a risk factor for Cholangiocarcinoma
T2  - Journal of Clinical and Experimental Hepatology
UR  - http://dx.doi.org/10.1016/j.jceh.2018.06.521
UR  - http://hdl.handle.net/10044/1/69404
VL  - 9
ER  -
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