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@article{Das:2023:10.1111/codi.16303,
author = {Das, B and Fehervari, M and Hamrang-Yousefi, S and Jiao, LR and Pai, M and Jenkins, JT and Spalding, DRC},
doi = {10.1111/codi.16303},
journal = {Colorectal Disease},
pages = {16--23},
title = {Pancreaticoduodenectomy with right hemicolectomy for advanced malignancy: a single UK hepatopancreaticobiliary centre experience},
url = {http://dx.doi.org/10.1111/codi.16303},
volume = {25},
year = {2023}
}

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TY  - JOUR
AB  - AimLocally advanced intestinal neoplasms including colon cancer may require radical en bloc pancreaticoduodenectomy and right hemicolectomy (PD-RC) to achieve curative, margin-negative resection, but the safety and benefit of this uncommon procedure has not been established. The Association of Coloproctology of Great Britain and Ireland IMPACT initiative has also highlighted a lack of awareness about current services available within the UK for patients with advanced colorectal cancer and concerns about low-volume centres managing complex cases. Thus, we aimed to review the feasibility, safety and long-term outcomes of this procedure at a single high-volume hepatopancreaticobiliary surgery unit in the UK.MethodA retrospective cohort study was performed using a database of all consecutive patients with intestinal cancer who had been referred to our regional advanced multidisciplinary team and undergone PD-RC in a 7-year period (2013–2020). Clinico-pathological and outcome data were reviewed.ResultsTen patients (mean age 54 ± 13, 8/10 men) were identified. Final histology revealed the primary tumour sites were colon (n = 7) and duodenum (n = 3). R0 resection was achieved in all cases. The major complication rate (Clavien–Dindo ≥ 3) was 10% (1/10) with no deaths within 90 days of surgery. The Kaplan–Meier estimated 5-year overall survival was 83.3% (95% CI 58.3%–100%). Univariate survival analysis identified perineural invasion and extra-colonic origin as predictors of poor survival (log-rank P < 0.05).ConclusionEn bloc PD-RC for locally advanced intestinal cancer can be performed safely with a high proportion of margin-negative resections and resultant long-term survival in carefully selected patients.
AU  - Das,B
AU  - Fehervari,M
AU  - Hamrang-Yousefi,S
AU  - Jiao,LR
AU  - Pai,M
AU  - Jenkins,JT
AU  - Spalding,DRC
DO  - 10.1111/codi.16303
EP  - 23
PY  - 2023///
SN  - 1462-8910
SP  - 16
TI  - Pancreaticoduodenectomy with right hemicolectomy for advanced malignancy: a single UK hepatopancreaticobiliary centre experience
T2  - Colorectal Disease
UR  - http://dx.doi.org/10.1111/codi.16303
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000848221200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://onlinelibrary.wiley.com/doi/10.1111/codi.16303
UR  - http://hdl.handle.net/10044/1/107664
VL  - 25
ER  -

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