Imperial College London

Professor Dale Wigley FRS

Faculty of MedicineDepartment of Medicine

Chair in Protein Crystallography
 
 
 
//

Contact

 

+44 (0)20 7594 8417d.wigley

 
 
//

Assistant

 

Mrs Kasia Pearce +44 (0)20 7594 2763

 
//

Location

 

258Sir Alexander Fleming BuildingSouth Kensington Campus

//

Summary

 

Summary

Professor Dale Wigley and his team at the Imperial College London are finding out what happens when the DNA in a cell is damaged, and how the cell deals with it. If DNA damage is not repaired correctly, mistakes occur in important genes which can lead to cancer.

Professor Wigley studies bacteria grown in the lab to investigate DNA repair. Bacteria are a simple model system and easier to work with than human cells. Understanding the DNA repair processes in bacteria will help Professor Wigley and his team gain insight into the similar, more complex, processes at work in human cells.

Learning more about how cells repair damage to their DNA could lead to new ways to prevent or treat cancer in the future.

mini cv

  • 1985 - BSc (Hons) Biochemistry, University of York                                  
  • 1988 - PhD Biochemistry, University of Bristol                                              
  • 1988-1990,Temporary Lecturer, University of Leicester                  
  • 1990-1992, SERC Advanced Fellow, University of York 
  • 1993-1997, Lecturer, University of Oxford            
  • 1997-2000, Reader, University of Oxford             
  • 2000 - 2010, Principal Scientist, Cancer Research UK                    
  • 2010 - 2014, Professor and Head of Division, Institute Cancer Research
  • 2014 - present, Professor, Section of Structural Biology, Department of Medicine, Imperial College London

 

Publications

Journals

Willhoft O, Ghoneim M, Lin C-L, et al., 2018, Structure and dynamics of the yeast SWR1-nucleosome complex, Science, Vol:362, ISSN:0036-8075, Pages:199-+

Ayala R, Willhoft O, Aramayo RJ, et al., 2018, Structure and regulation of the human INO80-nucleosome complex, Nature, Vol:556, ISSN:0028-0836, Pages:391-+

Aramayo RJ, Willhoft O, Ayala R, et al., 2018, Cryo-EM structures of the human INO80 chromatin-remodeling complex, Nature Structural & Molecular Biology, Vol:25, ISSN:1545-9993, Pages:37-+

Lin C-L, Chaban Y, Rees DM, et al., 2017, Functional characterization and architecture of recombinant yeast SWR1 histone exchange complex, Nucleic Acids Research, Vol:45, ISSN:0305-1048, Pages:7249-7260

Willhoft O, McCormack EA, Aramayo RJ, et al., 2017, Crosstalk within a functional INO80 complex dimer regulates nucleosome sliding, Elife, Vol:6, ISSN:2050-084X

More Publications