Imperial College London
Professor Dominic Withers

ProfessorDominicWithers

Faculty of Medicine, Institute of Clinical Sciences

Clinical Chair in Diabetes & Endocrinology
 
 
 
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Contact

 

d.withers

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Smith:2020:10.1172/jci130340,
author = {Smith, MA and Choudhury, AI and Glegola, JA and Viskaitis, P and Irvine, EE and Caldas, Custodio de Campos Silva P and Khadayate, S and Zeilhofer, HU and Withers, DJ},
doi = {10.1172/jci130340},
journal = {Journal of Clinical Investigation},
pages = {126--142},
title = {Extrahypothalamic GABAergic nociceptin-expressing neurons regulate AgRP neuron activity to control feeding behavior},
url = {http://dx.doi.org/10.1172/jci130340},
volume = {130},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Arcuate nucleus agouti-related peptide (AgRP) neurons play a central role in feeding and are under complex regulation by both homeostatic hormonal and nutrient signals and hypothalamic neuronal pathways. Feeding may also be influenced by environmental cues, sensory inputs and other behaviors implying the involvement of higher brain regions. However, whether such pathways modulate feeding through direct synaptic control of AgRP neuron activity is unknown. Here we show that nociceptin-expressing neurons in the anterior bed nuclei of the stria terminalis (aBNST) make direct GABAergic inputs onto AgRP neurons. We found that activation of these neurons inhibited AgRP neurons and feeding. Activity of these neurons increased upon food availability and their ablation resulted in obesity. Furthermore, these neurons received afferent inputs from a range of upstream brain regions as well as hypothalamic nuclei. Therefore, aBNST nociceptin/GABAergic neurons may act as a gateway to feeding behavior by connecting AgRP neurons to both homeostatic and non-homeostatic neuronal inputs.
AU  - Smith,MA
AU  - Choudhury,AI
AU  - Glegola,JA
AU  - Viskaitis,P
AU  - Irvine,EE
AU  - Caldas,Custodio de Campos Silva P
AU  - Khadayate,S
AU  - Zeilhofer,HU
AU  - Withers,DJ
DO  - 10.1172/jci130340
EP  - 142
PY  - 2020///
SN  - 0021-9738
SP  - 126
TI  - Extrahypothalamic GABAergic nociceptin-expressing neurons regulate AgRP neuron activity to control feeding behavior
T2  - Journal of Clinical Investigation
UR  - http://dx.doi.org/10.1172/jci130340
UR  - https://www.jci.org/articles/view/130340
UR  - http://hdl.handle.net/10044/1/73651
VL  - 130
ER  -
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