Imperial College London
Professor Dominic Withers

ProfessorDominicWithers

Faculty of Medicine, Institute of Clinical Sciences

Clinical Chair in Diabetes & Endocrinology
 
 
 
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Contact

 

d.withers

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Viskaitis:2017:10.1016/j.celrep.2017.11.089,
author = {Viskaitis, P and Irvine, EE and Smith, MA and Choudhury, AI and Alvarez-Curto, E and Glegola, JA and Hardy, DG and Pedroni, SMA and Paiva, Pessoa MR and Fernando, ABP and Katsouri, L and Sardini, A and Ungless, MA and Milligan, G and Withers, DJ},
doi = {10.1016/j.celrep.2017.11.089},
journal = {Cell Reports},
pages = {3559--3572},
title = {Modulation of SF1 neuron activity co-ordinately regulates both feeding behaviour and associated emotional states},
url = {http://dx.doi.org/10.1016/j.celrep.2017.11.089},
volume = {21},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Feeding requires the integration of homeostatic drives with emotional states relevant to food procurement in potentially hostile environments. The ventromedial hypothalamus (VMH) regulates feeding and anxiety, but how these are controlled in a concerted manner remains unclear. Using pharmacogenetic, optogenetic, and calcium imaging approaches with a battery of behavioral assays, we demonstrate that VMH steroidogenic factor 1 (SF1) neurons constitute a nutritionally sensitive switch, modulating the competing motivations of feeding and avoidance of potentially dangerous environments. Acute alteration of SF1 neuronal activity alters food intake via changes in appetite and feeding-related behaviors, including locomotion, exploration, anxiety, and valence. In turn, intrinsic SF1 neuron activity is low during feeding and increases with both feeding termination and stress. Our findings identify SF1 neurons as a key part of the neurocircuitry that controls both feeding and related affective states, giving potential insights into the relationship between disordered eating and stress-associated psychological disorders in humans.
AU  - Viskaitis,P
AU  - Irvine,EE
AU  - Smith,MA
AU  - Choudhury,AI
AU  - Alvarez-Curto,E
AU  - Glegola,JA
AU  - Hardy,DG
AU  - Pedroni,SMA
AU  - Paiva,Pessoa MR
AU  - Fernando,ABP
AU  - Katsouri,L
AU  - Sardini,A
AU  - Ungless,MA
AU  - Milligan,G
AU  - Withers,DJ
DO  - 10.1016/j.celrep.2017.11.089
EP  - 3572
PY  - 2017///
SN  - 2211-1247
SP  - 3559
TI  - Modulation of SF1 neuron activity co-ordinately regulates both feeding behaviour and associated emotional states
T2  - Cell Reports
UR  - http://dx.doi.org/10.1016/j.celrep.2017.11.089
UR  - http://hdl.handle.net/10044/1/54393
VL  - 21
ER  -
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