Publications
261 results found
Wood D, DeBacker G, Graham I, et al., 1997, A European Society of Cardiology survey of secondary prevention of coronary heart disease: Principal results, EUROPEAN HEART JOURNAL, Vol: 18, Pages: 1569-1582, ISSN: 0195-668X
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- Citations: 236
Pyke SDM, Wood DA, Kinmonth AL, et al., 1997, Change in coronary risk and coronary risk factor levels in couples following lifestyle intervention - The British Family Heart Study, ARCHIVES OF FAMILY MEDICINE, Vol: 6, Pages: 354-360, ISSN: 1063-3987
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- Citations: 53
Cowie MR, Wood DA, Coats A, et al., 1997, Incidence and aetiology of heart failure in the general population, Heart, Vol: 77, ISSN: 1355-6037
The contemporary incidence of heart failure in the UK is not known. A prospective survey of incident cases of heart failure presenting to 81 general practitioners and a district general hospital serving a population of 151 000 was conducted over 15 months. Cases were identified from hospital admissions and through a daily rapid access heart failure clinic to which GP's referred all new cases of suspected heart failure. Following a standardised interview, physical examination, ECG, CXR and echocardiogram all cases were reviewed by a panel of 3 cardiologists who determined whether the clinical case definition of heart failure was met and the aetiology. 171 incident cases of heart failure were identified (94M:77F) with no case aged under 35 years. Thirty five cases (20%) were identified from 122 referrals to the clinic, the remainder being acute hospital admissions. The incidence increased dramatically with age from 0.2 per 1000 population per annum in those aged 35-44 years to 11.6 in those aged 85 years or over and was higher in males than females (comparative incidence ratio 1.9 [95% CI 1.5-2.4] p<0.0001). The median age at presentation was 76 years. Aetiologies were ischaemic heart disease (36%), hypertension (15%), valve disease (6%), other (7%) but in 36% of cases the aetiology was unknown. Randomised controlled trials of heart failure are conducted in highly selected hospital cases with a strong bias towards younger patients and those with coronary artery disease as the aetiology. However, in the general population new cases of heart failure largely arise in the elderly and in over a third of cases the aetiology cannot be determined from non-invasive investigation. These findings have important implications for the investigation and management of new cases of heart failure in the general population.
Cowie MR, Struthers AD, Wood DA, et al., 1997, The predictive value of natriuretic peptide estimation for detecting new heart failure in general practice, Heart, Vol: 77, ISSN: 1355-6037
The validity of a clinical diagnosis of heart failure in general practice is known to be poor, leading to inappropriate treatment in as many as two thirds of such patients. However, confirming the diagnosis is time consuming requiring further clinical assessment by a specialist and investigation including echocardiography. Since elevation of plasma atrial (ANP and NT-ANP) and brain natriuretic peptides (BNP) occur in patients with heart failure we assessed the utility of measuring these peptides in 122 consecutive patients referred to a rapid access heart failure clinic with a new primary care diagnosis of heart failure. On the basis of clinical examination, chest x-ray and echocardiography a panel of 3 cardiologists confirmed that 35 of the 122 (29%) referred patients had new heart failure. The median level of ANP, BNP & NT-ANP (pmol/l) were much higher in those in heart failure compared with those not in heart failure (30.6 vs 13.0, 60.8 vs 11.9, 1271.3 vs 417.0 respectively, all p<0.00005). The Table displays the sensitivity, specificity and positive predictive value of the three peptides for cut-off levels where the negative predictive value was 98%: BNP ANP NT-ANP ≥22.22 pmol/l ≥18.06 pmol/l ≥537.56 pmol/l sensitivity (%) 97 97 97 specificity (%) 84 72 66 positive pred. value (%) 70 55 54 negative pred. value (%) 98 98 98 A multiple logistic regression model was used to determine the independent contribution of natriuretic peptides in detecting the presence of heart failure and there was no significant improvement in fit by adding either ANP (p=0.18) or NT-ANP (p=0.55) to a model containing BNP only. A plasma BNP level in patients with symptoms which are thought to be due to heart failure by a general practitioner may be a very useful (and relatively inexpensive) screening test for selecting patients who require assessment by a cardiologist.
Cowie MR, Mosterd A, Wood DA, et al., 1997, The epidemiology of heart failure, EUROPEAN HEART JOURNAL, Vol: 18, Pages: 208-225, ISSN: 0195-668X
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- Citations: 667
Wood DA, Roberts TL, Campbell M, 1997, Women married to men with myocardial infarction are at increased risk of coronary heart disease., J Cardiovasc Risk, Vol: 4, Pages: 7-11, ISSN: 1350-6277
AIM: To measure the prevalence of coronary heart disease (CHD) risk factors in the female partners of men with acute myocardial infarction (AMI). METHOD: Consecutive incident cases of men under 65 years of age with AMI surviving to 3 months, their female partners and female healthy controls matched for age and marital status drawn from the general population were investigated. RESULTS: One-hundred and seventeen cases of AMI in men under 65 years of age and 89 female partners were identified; 133 age- and sex-matched controls were examined for CHD risk factors. Cigarette smoking was more common among the younger partners (25-44 years of age) compared with controls. A body mass index > 28 kg/m2, systolic blood pressure > 150 mmHg, diastolic blood pressure > 90 mmHg and cholesterol > 6.5 mmol/l were all significantly more common in partners compared with controls. In a logistic regression of age, smoking habit, blood pressure, cholesterol and body mass index, based on 89 female partners and 132 controls with complete data, body mass index > 28 kg/m2 (odds ratio 2, 17, 95% CI 1.11-4.23) and cholesterol > 6.5 mmol/l (odds ratio 2.21, 95% CI 1.08-4.49) were both significantly more common in the female partners compared with controls. CONCLUSIONS: Women married to men with AMI have a higher frequency of CHD risk factors compared with married women in the general population, consistent with a shared family lifestyle putting both adults at higher risk of CHD. Screening blood relatives in families prematurely affected by CHD is widely advocated; such screening should include partners.
Cowie MR, Penston H, Wood DA, et al., 1997, A population survey of the incidence and aetiology of heart failure, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 29, Pages: 9130-9130, ISSN: 0735-1097
Cowie MR, Mosterd A, Wood DA, et al., 1997, The epidemiology of heart failure, European Heart Journal, Vol: 18, Pages: 208-225, ISSN: 0195-668X
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- Citations: 844
Lilliehöök B, Puska P, Schnocks H, et al., 1997, The European Heart Health Initiative. An expert report on European action in the field of CVD prevention., Publisher: European Heart Network
Sheppard MN, Davies MJ, Cary NRB, et al., 1997, A national survey of sudden unexpected cardiac or unexplained death in adults in the United Kingdom., JOURNAL OF PATHOLOGY, Vol: 182, Pages: A14-A14, ISSN: 0022-3417
S Sans, H Kesteloot, D Kromhout, et al., 1997, Task Force Report: The burden of cardiovascular diseases mortality in Europe, Eur Heart J, Vol: 18, Pages: 1231-1248
Cowie MR, Penston H, Wood DA, et al., 1996, A population-based survey of the incidence of heart failure, HEART, Vol: 75, Pages: 129-129, ISSN: 1355-6037
Bowker TJ, Clayton TC, Ingham J, et al., 1996, A British cardiac society survey of the potential for the secondary prevention of coronary disease: ASPIRE (Action on Secondary Prevention through Intervention to Reduce Events) - Principal results, HEART, Vol: 75, Pages: 334-342, ISSN: 1355-6037
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- Citations: 234
ROBERTS TL, WOOD DA, RIEMERSMA RA, et al., 1995, TRANS ISOMERS OF OLEIC AND LINOLEIC ACIDS IN ADIPOSE-TISSUE AND SUDDEN CARDIAC DEATH, LANCET, Vol: 345, Pages: 278-282, ISSN: 0099-5355
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- Citations: 122
WOOD DA, 1995, CHOLESTEROL-LOWERING DOES HAVE A ROLE IN SECONDARY PREVENTION, BRITISH HEART JOURNAL, Vol: 73, Pages: 4-5, ISSN: 0007-0769
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- Citations: 10
BARBIR M, BOWKER TJ, LUDMAN PF, et al., 1993, CARDIAC TRANSPLANT FOLLOW-UP BY ULTRAFAST CT SCANNING, CIRCULATION, Vol: 88, Pages: 420-420, ISSN: 0009-7322
Lowe GD, Wood DA, Douglas JT, et al., 1991, Relationships of plasma viscosity, coagulation and fibrinolysis to coronary risk factors and angina., Thromb Haemost, Vol: 65, Pages: 339-343, ISSN: 0340-6245
Plasma viscosity, molecular markers of activated coagulation and fibrinolysis (fibrinopeptides A and B beta 15-42), coagulation factors (fibrinogen and factor VII) and antiplasmins were measured in 529 men aged 35-54 years and related to new angina pectoris (n = 117) and to coronary risk factors in controls without angina (n = 412). Five major risk factors (cigarette-smoking, blood pressure, cholesterol, triglyceride and body mass index) were each associated with increases in plasma viscosity, coagulation factors, and imbalance of coagulation over fibrinolysis (increased ratio of fibrinopeptide A/fibrinopeptide B beta 15-42). Increased viscosity and fibrinogen in smokers were partly reversed in ex-smokers, but the imbalance of coagulation and fibrinolysis persisted. Cholesterol and triglyceride were also associated with increased antiplasmin activity. In men with angina, only fibrinogen was elevated compared to controls. We suggest that increased plasma viscosity and an imbalance of coagulation over fibrinolysis may be mechanisms by which known risk factors promote arterial thrombosis, but are not present in stable angina.
Fulton M, Thomson M, Elton RA, et al., 1988, Cigarette smoking, social class and nutrient intake: relevance to coronary heart disease., Eur J Clin Nutr, Vol: 42, Pages: 797-803, ISSN: 0954-3007
The association of cigarette smoking habits and social class with nutrient intake was investigated in 162 men aged 45-54 using a 7-d weighed dietary record. Cigarette smokers had a significantly lower intake of fibre and polyunsaturated fatty acids and a lower P:S ratio than non-smokers. Fibre intake was lower in men in the manual compared to the non-manual group but smoking was a more powerful influence than social class. The differences in nutrient intake were accompanied by differences in the consumption of polyunsaturated margarines and cereal-containing foods. These results should be considered in the explanation of the increased incidence of coronary heart disease in smokers.
Cowie M, Fox KF, Wood DA, et al., N-terminal Pro-BNP better predicts prognosis in patients presenting with heart failure for the first time than NT-pro-ANP or BNP, EUROPEAN HEART JOURNAL, Vol: 21, Pages: 536-536, ISSN: 0195-668X
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- Citations: 2
De Hert M, Dekker JM, Wood D, et al., A consensus statement by the European Psychiatric Association (EPA) on cardiovascular disease and Diabetes in patients with severe mental illness Supported by the European Association for the Study of Diabetes (EASD) and der European Society of Cardiology (ESC)*, PSYCHOPHARMAKOTHERAPIE, Vol: 17, Pages: 3-+, ISSN: 0944-6877
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- Citations: 1
GRAHAM I, ROBINSON K, TOMKIN G, et al., A ONE-YEAR MULTICENTER STUDY OF SIMVASTATIN IN THE TREATMENT OF HYPERCHOLESTEROLEMIA, BRITISH JOURNAL OF CLINICAL PRACTICE, Vol: 48, Pages: 231-235, ISSN: 0007-0947
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