Imperial College London


Faculty of MedicineDepartment of Surgery & Cancer

Research Associate







ICTEM buildingHammersmith Campus






  1. Leach DA, Panagopoulos V, Nash C, Bevan C, Thomson AA, Selth LA, et al. Cell-lineage specificity and role of AP-1 in the prostate fibroblast androgen receptor cistrome. Mol Cell Endocrinol. 2016.
  2. Leach DA, Powell SM, Bevan CL. WOMEN IN CANCER THEMATIC REVIEW: New roles for nuclear receptors in prostate cancer. Endocr Relat Cancer. 2016;23(11):T85-T108.
  3. Leach DA, Trotta AP, Need EF, Risbridger GP, Taylor RA, Buchanan G. The prognostic value of stromal FK506-binding protein 1 and androgen receptor in prostate cancer outcome. Prostate. 2016.
  4. Leach DA, Need EF, Toivanen R, Trotta AP, Palenthorpe HM, Tamblyn DJ, et al. Stromal androgen receptor regulates the composition of the microenvironment to influence prostate cancer outcome. Oncotarget. 2015.
  5. Leach DA, Need EF, Trotta AP, Grubisha MJ, Defranco DB, Buchanan G. Hic-5 influences genomic and non-genomic actions of the androgen receptor in prostate myofibroblasts. Mol Cell Endocrinol. 2014;384(1-2):185-99.
  6. Panagopoulos V, Liapis V, Zinonos I, Hay S, Leach DA, Ingman W, et al. Peroxidase enzymes inhibit osteoclast differentiation and bone resorption. Mol Cell Endocrinol. 2017;440:8-15.
  7. Smith E, Palethorpe HM, Ruszkiewicz AR, Edwards S, Leach DA, Underwood TJ, et al. Androgen Receptor and Androgen-Responsive Gene FKBP5 Are Independent Prognostic Indicators for Esophageal Adenocarcinoma. Dig Dis Sci. 2016;61(2):433-43.
  8. Panagopoulos V, Zinonos I, Leach DA, Hay SJ, Liapis V, Zysk A, et al. Uncovering a new role for peroxidase enzymes as drivers of angiogenesis. Int J Biochem Cell Biol. 2015;68:128-38.
  9. Need EF, Selth LA, Trotta AP, Leach DA, Giorgio L, O'Loughlin MA, et al. The unique transcriptional response produced by concurrent estrogen and progesterone treatment in breast cancer cells results in upregulation of growth factor pathways and switching from a Luminal A to a Basal-like subtype. BMC Cancer. 2015;15:791.
  10. Tan C, Shard C, Ranieri E, Hynes K, Pham DH, Leach D, et al. Mutations of protocadherin 19 in female epilepsy (PCDH19-FE) lead to allopregnanolone deficiency. Hum Mol Genet. 2015;24(18):5250-9.
  11. Bianco-Miotto T, Trotta AP, Need EF, Lee AM, Ochnik AM, Giorgio L, et al. Molecular and structural basis of androgen receptor responses to dihydrotestosterone, medroxyprogesterone acetate and Delta(4)-tibolone. Mol Cell Endocrinol. 2014;382(2):899-908.
  12. Solomon JD, Heitzer MD, Liu TT, Beumer JH, Parise RA, Normolle DP, et al. VDR activity is differentially affected by Hic-5 in prostate cancer and stromal cells. Mol Cancer Res. 2014;12(8):1166-80.
  13. Trotta AP, Need EF, Selth LA, Chopra S, Pinnock CB, Leach DA, et al. Knockdown of the cochaperone SGTA results in the suppression of androgen and PI3K/Akt signaling and inhibition of prostate cancer cell proliferation. Int J Cancer. 2013;133(12):2812-23.



Leach DA, Buchanan G, 2018, Protocols for Studies on Stromal Cells in Prostate Cancer., Methods Mol Biol, Vol:1786, Pages:207-218

Leach DA, Buchanan G, 2017, Stromal Androgen Receptor in Prostate Cancer Development and Progression, Cancers, Vol:9, ISSN:2072-6694

Leach DA, Powell SM, Bevan C, 2016, New roles for nuclear receptors in prostate cancer, Endocrine-related Cancer, Vol:23, ISSN:1479-6821, Pages:T85-T108

Leach DA, Panagopoulos V, Nash C, et al., 2016, Cell-lineage specificity and role of AP-1 in the prostate fibroblast androgen receptor cistrome., Molecular and Cellular Endocrinology, Vol:439, ISSN:1872-8057, Pages:261-272

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