Summary
Summary
Prostate Cancer Foundation Young Investigator.
My principal research interests are in the mesechymal cells of the prostate cancer microenvironment, both at the primary site and in metastatic sites (particularly the liver). Specifically, I investigate how the mesenchymal cells influence the behavior and characteristics of cancer cells. I am also interested in androgen/nuclear receptor signalling, the cell specificity of the signalling pathway, and how it alters with disease progression in both cancer and microenvironment. To investigate these interests I employ a number of techniques, including 3D-in vitro models, patient explant assays, next gen sequencing, IHC.
Publications
1. Leach, D.A., et al., Enzalutamide, a prostate cancer therapeutic, downregulates TMPRSS2 in lung and reduces cellular entry of SARS-CoV-2. Research Square, 2021.
2. Leach, D.A., G.N. Brooke, and C.L. Bevan, Roles of steroid receptors in the lung and COVID-19. Essays Biochem, 2021.
3. Leach, D.A., et al., The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells. Nat Commun, 2021. 12(1): p. 4068.
4. Leach, D.A. and G. Buchanan, Protocols for Studies on Stromal Cells in Prostate Cancer. Methods Mol Biol, 2018. 1786: p. 207-218.
5. Leach, D.A., et al., The prognostic value of stromal FK506-binding protein 1 and androgen receptor in prostate cancer outcome. Prostate, 2017. 77(2): p. 185-195.
6. Leach, D.A. and G. Buchanan, Stromal Androgen Receptor in Prostate Cancer Development and Progression. Cancers (Basel), 2017. 9(1).
7. Leach, D.A., et al., Cell-lineage specificity and role of AP-1 in the prostate fibroblast androgen receptor cistrome. Mol Cell Endocrinol, 2017. 439: p. 261-272.
8. Leach, D.A., S.M. Powell, and C.L. Bevan, WOMEN IN CANCER THEMATIC REVIEW: New roles for nuclear receptors in prostate cancer. Endocr Relat Cancer, 2016. 23(11): p. T85-T108.
9. Leach, D.A., et al., Stromal androgen receptor regulates the composition of the microenvironment to influence prostate cancer outcome. Oncotarget, 2015. 6(18): p. 16135-50.
10. Leach, D.A., et al., Hic-5 influences genomic and non-genomic actions of the androgen receptor in prostate myofibroblasts. Mol Cell Endocrinol, 2014. 384(1-2): p. 185-99.
Publications
Journals
Fletcher C, Zamarbide Losada J, Sulpice E, et al., 2023, Apoptosis-modulatory miR-361-3p as a novel treatment target in endocrine-responsive and endocrine-resistant breast cancer, Journal of Endocrinology, Vol:256, ISSN:0022-0795, Pages:1-20
Buxton AK, Abbasova S, Bevan CL, et al., 2022, Liver Microenvironment Response to Prostate Cancer Metastasis and Hormonal Therapy, Cancers, Vol:14
Leach DA, Fernandes RC, Bevan CL, 2022, Cellular specificity of androgen receptor, coregulators, and pioneer factors in prostate cancer, Endocrine Oncology, Vol:2, Pages:R112-R131
Fletcher C, Deng L, Orafidiya F, et al., 2022, A non-coding RNA balancing act: miR-346-induced DNA damage is limited by the long non-coding RNA NORAD in prostate cancer, Molecular Cancer, Vol:21, ISSN:1476-4598
Ma KC, Hale JE, Grad YH, et al., 2022, Trends in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Seroprevalence in Massachusetts Estimated from Newborn Screening Specimens, Clinical Infectious Diseases, Vol:75, ISSN:1058-4838, Pages:E105-E113