Publications
505 results found
Sun Y, Meier J, Hatami N, et al., 2009, Endoscopic Fluorescence Lifetime Imaging Applied to Intraoperative Cancer Diagnosis for Non-Invasive Optical Biopsy, 15th Annual Cancer Research Symposium
Sun Y, Phipps J, Elson DS, et al., 2009, Fluorescence lifetime imaging microscopy: <i>in vivo</i> application to diagnosis of oral carcinoma, OPTICS LETTERS, Vol: 34, Pages: 2081-2083, ISSN: 0146-9592
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- Citations: 101
Sun Y, Phipps J, Elson DS, et al., 2009, Fluorescence Lifetime Imaging Microscopy (FLIM) for Cancer Demarcation during Medical Surgery, 10th Annual UC Systemwide Bioengineering Symposium
Elson DS, Yang G-Z, 2009, The principles and role of medical imaging in surgery, Key Topics in Surgical Research and Methodology, Editors: Darzi, Athanasiou, Berlin, Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. K, ISBN: 978-3540719144
Lee ACH, Elson DS, Neil MA, et al., 2009, Solid-state semiconductors are better alternatives to arc-lamps for efficient and uniform illumination in minimal access surgery, Scientific Congress of the Royal-College-of-Surgeons-of-Edinburgh/College-of-Surgeons-of-Hong-Kong (RCSED/CSHK), Publisher: SPRINGER, Pages: 518-526, ISSN: 0930-2794
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- Citations: 19
Lee ACH, Elson DS, Neil MA, et al., 2009, Solid-state semiconductors are better alternatives to arc-lamps for efficient and uniform illumination in minimal access surgery., Surg Endosc, Vol: 23, Pages: 518-526
INTRODUCTION: Current arc-lamp illumination systems have a number of technical and ergonomic limitations. White light-emitting diodes (LEDs) are energy-efficient solid-state lighting devices which are small, durable and inexpensive. Their use as an alternative to arc-lamp light sources in minimal access surgery has not been explored. This study aims to develop an LED-based endo-illuminator and to determine its lighting characteristics for use in minimal access surgery. METHODS: We developed an LED endo-illuminator using a white LED mounted at the tip of a steel rod. Offline image analysis was carried out to compare the illuminated field using the LED endo-illuminator or an arc-lamp based endoscope in terms of uniformity, shadow sharpness and overall image intensity. Direct radiometric power measurements in light intensity and stability were obtained. Visual perception of fine details at the peripheral endoscopic field was assessed by 13 subjects using the different illumination systems. RESULTS: Illumination from the LED endo-illuminator was more uniform compared to illumination from an arc-lamp source, especially at the closer distance of 4 cm (0.0006 versus 0.0028 arbitrary units--lower value indicates more uniform illumination). The shadows were also sharper (edge widths of 16 versus 44 pixels for the first edge and 15 versus 61 pixels for the second edge). The overall mean image intensity was higher (127 versus 100 arbitrary units) when using the autoshutter mode despite the lower direct radiometric power, about one tenth of the arc-lamp endoscopic system. The illumination was also more stable with less flickering (0.02% versus 5% of total power in non-DC components). Higher median scores on visual perception was also obtained (237 versus 157, p < 0.001). CONCLUSION: The LED endo-illuminator provides more uniform illumination with sharper shadows, less flickering and better illumination for visual perception than the arc-lamp-based system currently used.
McGinty J, Dunsby C, Auksorius E, et al., 2009, Chapter 4 Multidimensional fluorescence imaging
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- Citations: 3
Stoyanov D, Elson D, Yang G-Z, 2009, Illumination Position Estimation for 3D Soft-Tissue Reconstruction in Robotic Minimally Invasive Surgery, IEEE RSJ International Conference on Intelligent Robots and Systems, Publisher: IEEE, Pages: 2628-2633
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- Citations: 7
Li R, Elson DS, Dunsby C, et al., 2009, A study on optical modulation signal and tissue displacement in Ultrasound Modulated Optical Tomography, Conference on Photons Plus Ultrasound - Imaging and Sensing 2009, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X
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- Citations: 1
Koh KR, Wood TC, Goldin RD, et al., 2009, Visible and near infrared autofluorescence and hyperspectral imaging spectroscopy for the investigation of colorectal lesions and detection of exogenous fluorophores, Conference on Advanced Biomedical and Clinical Diagnostic Systems VII, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X
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- Citations: 7
Song L, Elson DS, 2009, Multi-exposure speckle imaging using phantoms for blood flow and tissue perfusion, 8th Pacific Rim Conference on Lasers and Electro-Optics, Publisher: IEEE, Pages: 1127-+
Noonan DP, Mountney P, Elson DS, et al., 2009, A Stereoscopic Fibroscope for Camera Motion and 3D Depth Recovery during Minimally Invasive Surgery, IEEE International Conference on Robotics and Automation, Publisher: IEEE, Pages: 3274-3279, ISSN: 1050-4729
This paper introduces a stereoscopic fibroscope imaging system for Minimally Invasive Surgery (MIS) and examines the feasibility of utilizing images transmitted from the distal fibroscope tip to a proximally mounted CCD camera to recover both camera motion and 3D scene information. Fibre image guides facilitate instrument miniaturization and have the advantage of being more easily integrated with articulated robotic instruments. In this paper, twin 10,000 pixel coherent fibre bundles (590 mu m diameter) have been integrated into a bespoke laparoscopic imaging instrument. Images captured by the system have been used to build a 3D map of the environment and reconstruct the laparoscope's 3D pose and motion using a SLAM algorithm. Detailed phantom validation of the system demonstrates its practical value and potential for flexible MIS instrument integration due to the small footprint and flexible nature of the fibre image guides.
Mountney P, Giannarou S, Elson D, et al., 2009, Optical Biopsy Mapping for Minimally Invasive Cancer Screening, Pages: 483-490
Noonan D, Mountney P, Elson D, et al., 2009, A Stereoscopic Fibroscope for Camera Motion and 3D Depth Recovery During Minimally Invasive Surgery, International Conference on Robotics and Automation, Publisher: IEEE, Pages: 4463-4468
Noonan D, Elson D, Mylonas G, et al., 2009, Laser Induced Fluorescence and Reflected White Light Imaging for Robot-Assisted MIS, IEEE Transactions on Biomedical Engineering, Vol: 56, Pages: 889-892
McGinty J, Dunsby C, Auksorius E, et al., 2009, Multidimensional fluorescence imaging, FRET AND FLIM TECHNIQUES, Editors: Gadella, Publisher: ELSEVIER SCIENCE BV, Pages: 133-169, ISBN: 978-0-08-054958-3
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- Citations: 2
McGinty J, Dunsby C, Auksorius E, et al., 2009, Multidimensional fluorescence imaging, Laboratory Techniques in Biochemistry and Molecular Biology (FLIM and FRET techniques), Editors: Gadella, Publisher: Elsevier, ISBN: 9780080915128
This volume reviews the techniques Förster Resonance Energy Transfer (FRET) and Fluorescence Lifetime Imaging Microscopy (FLIM) providing researchers with step by step protocols and handy hints and tips.
Wood TC, Thiemjarus S, Koh KR, et al., 2008, Optimal feature selection applied to multispectral fluorescence imaging, Pages: 222-229, ISSN: 0302-9743
Recent rapid developments in multi-modal optical imaging have created a significant clinical demand for its in vivo - in situ application. This offers the potential for real-time tissue characterization, functional assessment, and intra-operative guidance. One of the key requirements for in vivo consideration is to minimise the acquisition window to avoid tissue motion and deformation, whilst making the best use of the available photons to account for correlation or redundancy between different dimensions. The purpose of this paper is to propose a feature selection framework to identify the best combination of features for discriminating between different tissue classes such that redundant or irrelevant information can be avoided during data acquisition. The method is based on a Bayesian framework for feature selection by using the receiver operating characteristic curves to determine the most pertinent data to capture. This represents a general technique that can be applied to different multi-modal imaging modalities and initial results derived from phantom and ex vivo tissue experiments demonstrate the potential clinical value of the technique. © 2008 Springer Berlin Heidelberg.
Nadeau VJ, Elson DS, Hanna GB, et al., 2008, Modelling of a laser-pumped light source for endoscopic surgery, ISSN: 0277-786X
A white light source, based on illumination of a yellow phosphor with a fibre-coupled blue-violet diode laser, has been designed and built for use in endoscopic surgery. This narrow light probe can be integrated into a standard laparoscope or inserted into the patient separately via a needle. We present a Monte Carlo model of light scattering and phosphorescence within the phosphor/silicone matrix at the probe tip, and measurements of the colour, intensity, and uniformity of the illumination. Images obtained under illumination with this light source are also presented, demonstrating the improvement in illumination quality over existing endoscopic light sources. This new approach to endoscopic lighting has the advantages of compact design, improved ergonomics, and more uniform illumination in comparison with current technologies. © 2008 SPIE.
Galletly NP, McGinty J, Dunsby C, et al., 2008, Fluorescence lifetime imaging distinguishes basal cell carcinoma from surrounding uninvolved skin, BRITISH JOURNAL OF DERMATOLOGY, Vol: 159, Pages: 152-161, ISSN: 0007-0963
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- Citations: 104
Kennedy GT, Elson DS, Hares JD, et al., 2008, Fluorescence lifetime imaging using light emitting diodes, JOURNAL OF PHYSICS D-APPLIED PHYSICS, Vol: 41, ISSN: 0022-3727
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- Citations: 5
Sun Y, Liu R, Elson DS, et al., 2008, Simultaneous time- and wavelength-resolved fluorescence spectroscopy for near real-time tissue diagnosis, OPTICS LETTERS, Vol: 33, Pages: 630-632, ISSN: 0146-9592
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- Citations: 47
McGinty J, Tahir KB, Soloviev VY, et al., 2008, Time-domain fluorescence lifetime tomography
We present a platform for fluorescence lifetime tomography utilising tuneable supercontinuum excitation and wide-field time-gated technology. Applied to optical projection and diffuse fluorescence tomography, we demonstrate 3D time-resolved fluorescence reconstruction in transparent and scattering phantoms.
Wood TC, Thiemjarus S, Koh KR, et al., 2008, Optimal feature selection applied to multispectral fluorescence imaging., Med Image Comput Comput Assist Interv, Vol: 11, Pages: 222-229
Recent rapid developments in multi-modal optical imaging have created a significant clinical demand for its in vivo--in situ application. This offers the potential for real-time tissue characterization, functional assessment, and intra-operative guidance. One of the key requirements for in vivo consideration is to minimise the acquisition window to avoid tissue motion and deformation, whilst making the best use of the available photons to account for correlation or redundancy between different dimensions. The purpose of this paper is to propose a feature selection framework to identify the best combination of features for discriminating between different tissue classes such that redundant or irrelevant information can be avoided during data acquisition. The method is based on a Bayesian framework for feature selection by using the receiver operating characteristic curves to determine the most pertinent data to capture. This represents a general technique that can be applied to different multi-modal imaging modalities and initial results derived from phantom and ex vivo tissue experiments demonstrate the potential clinical value of the technique.
Wood TC, Thiemjarus S, Koh KR, et al., 2008, Optimal Feature Selection Applied to Multispectral Fluorescence Imaging, 11th International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI2008), Publisher: SPRINGER-VERLAG BERLIN, Pages: 222-229, ISSN: 0302-9743
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- Citations: 4
Nadeau VJ, Elson DS, Neil MAA, et al., 2008, Laser-Pumped Endoscopic Illumination Source, 30th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society, Publisher: IEEE, Pages: 2059-+, ISSN: 1557-170X
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- Citations: 7
Koh K, Wood T, Zhang H, et al., 2008, Fluorescence excitation spectroscopic imaging with a tuneable light source and dimensionality reduction using FR-IsoMap, Conference on Advanced Biomedical and Clinical Diagnostic Systems VI, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X
Nadeau VJ, Elson DS, Neil MAA, et al., 2008, Laser-pumped endoscopic illumination source., Annu Int Conf IEEE Eng Med Biol Soc, Vol: 2008, Pages: 2059-2062, ISSN: 2375-7477
Light sources currently employed in endoscopy have a number of disadvantages including inefficiency, high temperature, non-uniform illumination, and the production of shadow-less images. In this paper, we present a novel endoscopic illumination source, based on the use of a blue-violet laser diode in combination with a yellow phosphor for the production of white light. By using this approach, the resulting illumination source is more compact and potentially more ergonomic than those currently used in endoscopy. Spectral measurements of the emitted light indicate that it has a colour similar to that of daylight, and images obtained under illumination with this light source indicate that it provides more uniform illumination and sharper shadows than standard endoscopic light sources.
Soloviev VY, Tahir KB, McGinty J, et al., 2007, Fluorescence lifetime imaging by using time-gated data acquisition, APPLIED OPTICS, Vol: 46, Pages: 7384-7391, ISSN: 1559-128X
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- Citations: 49
Poher V, Zhang HX, Kennedy GT, et al., 2007, Optical sectioning microscopes with no moving parts using a micro-stripe array light emitting diode, OPTICS EXPRESS, Vol: 15, Pages: 11196-11206, ISSN: 1094-4087
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- Citations: 45
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