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@article{Munblit:2021:cid/ciaa1535,
author = {Munblit, D and Nekliudov, NA and Bugaeva, P and Blyuss, O and Kislova, M and Listovskaya, E and Gamirova, A and Shikhaleva, A and Belyaev, V and Timashev, P and Warner, JO and Comberiati, P and Apfelbacher, C and Bezrukov, E and Politov, ME and Yavorovskiy, A and Bulanova, E and Tsareva, N and Avdeev, S and Kapustina, VA and Pigolkin, YI and Dankwa, EA and Kartsonaki, C and Pritchard, MG and Victor, F and Svistunov, AA and Butnaru, D and Glybochko, P},
doi = {cid/ciaa1535},
journal = {Clinical Infectious Diseases},
pages = {1--11},
title = {StopCOVID cohort: An observational study of 3,480 patients admitted to the Sechenov University hospital network in Moscow city for suspected COVID-19 infection},
url = {http://dx.doi.org/10.1093/cid/ciaa1535},
volume = {73},
year = {2021}
}

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TY  - JOUR
AB  - BACKGROUND: The epidemiology, clinical course, and outcomes of COVID-19 patients in the Russian population are unknown. Information on the differences between laboratory-confirmed and clinically-diagnosed COVID-19 in real-life settings is lacking. METHODS: We extracted data from the medical records of adult patients who were consecutively admitted for suspected COVID-19 infection in Moscow, between April 8 and May 28, 2020. RESULTS: Of the 4261 patients hospitalised for suspected COVID-19, outcomes were available for 3480 patients (median age 56 years (interquartile range 45-66). The commonest comorbidities were hypertension, obesity, chronic cardiac disease and diabetes. Half of the patients (n=1728) had a positive RT-PCR while 1748 were negative on RT-PCR but had clinical symptoms and characteristic CT signs suggestive of COVID-19 infection.No significant differences in frequency of symptoms, laboratory test results and risk factors for in-hospital mortality were found between those exclusively clinically diagnosed or with positive SARS-CoV-2 RT-PCR.In a multivariable logistic regression model the following were associated with in-hospital mortality; older age (per 1 year increase) odds ratio [OR] 1.05 (95% confidence interval (CI) 1.03 - 1.06); male sex (OR 1.71, 1.24 - 2.37); chronic kidney disease (OR 2.99, 1.89 - 4.64); diabetes (OR 2.1, 1.46 - 2.99); chronic cardiac disease (OR 1.78, 1.24 - 2.57) and dementia (OR 2.73, 1.34 - 5.47). CONCLUSIONS: Age, male sex, and chronic comorbidities were risk factors for in-hospital mortality. The combination of clinical features were sufficient to diagnoseCOVID-19 infection indicating that laboratory testing is not critical in real-life clinical practice.
AU  - Munblit,D
AU  - Nekliudov,NA
AU  - Bugaeva,P
AU  - Blyuss,O
AU  - Kislova,M
AU  - Listovskaya,E
AU  - Gamirova,A
AU  - Shikhaleva,A
AU  - Belyaev,V
AU  - Timashev,P
AU  - Warner,JO
AU  - Comberiati,P
AU  - Apfelbacher,C
AU  - Bezrukov,E
AU  - Politov,ME
AU  - Yavorovskiy,A
AU  - Bulanova,E
AU  - Tsareva,N
AU  - Avdeev,S
AU  - Kapustina,VA
AU  - Pigolkin,YI
AU  - Dankwa,EA
AU  - Kartsonaki,C
AU  - Pritchard,MG
AU  - Victor,F
AU  - Svistunov,AA
AU  - Butnaru,D
AU  - Glybochko,P
DO  - cid/ciaa1535
EP  - 11
PY  - 2021///
SN  - 1058-4838
SP  - 1
TI  - StopCOVID cohort: An observational study of 3,480 patients admitted to the Sechenov University hospital network in Moscow city for suspected COVID-19 infection
T2  - Clinical Infectious Diseases
UR  - http://dx.doi.org/10.1093/cid/ciaa1535
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33035307
UR  - https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa1535/5920244
UR  - http://hdl.handle.net/10044/1/83465
VL  - 73
ER  -

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DR. DANIEL MUNBLIT

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