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@article{Munblit:2021:10.1111/cea.13997,
author = {Munblit, D and Bobkova, P and Spiridonova, E and Shikhaleva, A and Gamirova, A and Blyuss, O and Nekliudov, N and Bugaeva, P and Andreeva, M and DunnGalvin, A and Comberiati, P and Apfelbacher, C and Genuneit, J and Avdeev, S and Kapustina, V and Guekht, A and Fomin, V and Svistunov, AA and Timashev, P and Subbot, VS and Royuk, VV and Drake, TM and Hanson, SW and Merson, L and Carson, G and Horby, P and Sigfrid, L and Scott, JT and Semple, MG and Warner, JO and Vos, T and Olliaro, P and Glybochko, P and Butnaru, D},
doi = {10.1111/cea.13997},
journal = {Clinical and Experimental Allergy},
pages = {1107--1120},
title = {Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID-19},
url = {http://dx.doi.org/10.1111/cea.13997},
volume = {51},
year = {2021}
}

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TY  - JOUR
AB  - BackgroundThe long-term sequalae of COVID-19 remain poorly characterized. We assessed persistent symptoms in previously hospitalized patients with COVID-19 and assessed potential risk factors.MethodsData were collected from patients discharged from 4 hospitals in Moscow, Russia between 8 April and 10 July 2020. Participants were interviewed via telephone using an ISARIC Long-term Follow-up Study questionnaire.Results2,649 of 4755 (56%) discharged patients were successfully evaluated, at median 218 (IQR 200, 236) days post-discharge. COVID-19 diagnosis was clinical in 1291 and molecular in 1358. Most cases were mild, but 902 (34%) required supplemental oxygen and 68 (2.6%) needed ventilatory support. Median age was 56 years (IQR 46, 66) and 1,353 (51.1%) were women. Persistent symptoms were reported by 1247 (47.1%) participants, with fatigue (21.2%), shortness of breath (14.5%) and forgetfulness (9.1%) the most common symptoms and chronic fatigue (25%) and respiratory (17.2%) the most common symptom categories. Female sex was associated with any persistent symptom category OR 1.83 (95% CI 1.55 to 2.17) with association being strongest for dermatological (3.26, 2.36 to 4.57) symptoms. Asthma and chronic pulmonary disease were not associated with persistent symptoms overall, but asthma was associated with neurological (1.95, 1.25 to 2.98) and mood and behavioural changes (2.02, 1.24 to 3.18), and chronic pulmonary disease was associated with chronic fatigue (1.68, 1.21 to 2.32).ConclusionsAlmost half of adults admitted to hospital due to COVID-19 reported persistent symptoms 6 to 8 months after discharge. Fatigue and respiratory symptoms were most common, and female sex was associated with persistent symptoms.
AU  - Munblit,D
AU  - Bobkova,P
AU  - Spiridonova,E
AU  - Shikhaleva,A
AU  - Gamirova,A
AU  - Blyuss,O
AU  - Nekliudov,N
AU  - Bugaeva,P
AU  - Andreeva,M
AU  - DunnGalvin,A
AU  - Comberiati,P
AU  - Apfelbacher,C
AU  - Genuneit,J
AU  - Avdeev,S
AU  - Kapustina,V
AU  - Guekht,A
AU  - Fomin,V
AU  - Svistunov,AA
AU  - Timashev,P
AU  - Subbot,VS
AU  - Royuk,VV
AU  - Drake,TM
AU  - Hanson,SW
AU  - Merson,L
AU  - Carson,G
AU  - Horby,P
AU  - Sigfrid,L
AU  - Scott,JT
AU  - Semple,MG
AU  - Warner,JO
AU  - Vos,T
AU  - Olliaro,P
AU  - Glybochko,P
AU  - Butnaru,D
DO  - 10.1111/cea.13997
EP  - 1120
PY  - 2021///
SN  - 0954-7894
SP  - 1107
TI  - Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID-19
T2  - Clinical and Experimental Allergy
UR  - http://dx.doi.org/10.1111/cea.13997
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000684357100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://onlinelibrary.wiley.com/doi/10.1111/cea.13997
VL  - 51
ER  -

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DR. DANIEL MUNBLIT

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