Imperial College London
Alternate

ProfessorDavidBrooks

Faculty of Medicine, Department of Brain Sciences

Visiting Professor
 
 
 
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Contact

 

david.brooks

 
 
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Assistant

 

Ms Hyacinth Henry +44 (0)20 3313 3172

 
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Location

 

U106Block B Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

1044 results found

DETTMERS C, FINK GR, LEMON RN, STEPHAN KM, PASSINGHAM RE, SILBERSWEIG D, HOLMES A, RIDDING MC, BROOKS DJ, FRACKOWIAK RSJet al., 1995, RELATION BETWEEN CEREBRAL-ACTIVITY AND FORCE IN THE MOTOR AREAS OF THE HUMAN BRAIN, JOURNAL OF NEUROPHYSIOLOGY, Vol: 74, Pages: 802-815, ISSN: 0022-3077

Journal article

Burn DJ, Rinne JO, Quinn NP, Lees AJ, Marsden CD, Brooks DJet al., 1995, Striatal opioid receptor binding in Parkinson's disease, striatonigral degeneration and Steele-Richardson-Olszewski syndrome, A [11C]diprenorphine PET study., Brain, Vol: 118 ( Pt 4), Pages: 951-958, ISSN: 0006-8950

The clinical differentiation of Parkinson's disease from the striatonigral degeneration (SND) type of multiple system atrophy (MSA) and Steele-Richardson-Olszewski syndrome (SRO) may be difficult. This is reflected by a 20-25% misdiagnosis rate in clinicopathological series of cases labelled as 'Parkinson's disease' in life. The caudate and putamen contain a high density of opioidergic neurons and receptors which have a close anatomical and physiological relationship with the dopaminergic system. We used [11C]diprenorphine with PET to investigate striatal opioid receptor binding in groups of patients with clinically defined Parkinson's disease (n = 8), SND (n = 7) and SRO (n = 6), compared with normal controls (n = 8). There was no significant difference between mean ligand binding in the putamen and caudate of Parkinson's disease cases when compared with normals. Mean putamen, but not caudate, opioid receptor binding was significantly reduced in the SND group, when compared with normals. By contrast, in the SRO group, both mean caudate and putamen opioid receptor binding was significantly reduced when compared with both normal and Parkinson's disease groups. When considering the individual patients, none of the eight Parkinson's disease cases (0%), none of the seven SND cases (0%), but four of the six SRO cases (67%) had caudate opioid receptor binding that was > 2.5 SDs below the normal mean. Corresponding figures for putamen opioid receptor binding were: none of the Parkinson's disease cases (0%); three of the SND cases (43%); and all of the SRO cases (100%). We conclude that there are differences in the pattern of opioid receptor binding in the striatum of Parkinson's disease, SND and SRO patients, as determined by [11C]diprenorphine PET. The different binding patterns may help to differentiate these akinetic-rigid syndromes in life.

Journal article

JAHANSHAHI M, JENKINS H, BROWN RG, MARSDEN CD, PASSINGHAM RE, BROOKS DJet al., 1995, SELF-INITIATED VERSUS EXTERNALLY TRIGGERED MOVEMENTS .1. AN INVESTIGATION USING MEASUREMENT OF REGIONAL CEREBRAL BLOOD-FLOW WITH PET AND MOVEMENT-RELATED POTENTIALS IN NORMAL AND PARKINSONS-DISEASE SUBJECTS, BRAIN, Vol: 118, Pages: 913-933, ISSN: 0006-8950

Journal article

PREVETT MC, DUNCAN JS, JONES T, FISH DR, BROOKS DJet al., 1995, DEMONSTRATION OF THALAMIC ACTIVATION DURING TYPICAL ABSENCE SEIZURES USING (H2O)-O-15 AND PET, NEUROLOGY, Vol: 45, Pages: 1396-1402, ISSN: 0028-3878

Journal article

Turjanski N, Weeks R, Dolan R, Harding AE, Brooks DJet al., 1995, Striatal D1 and D2 receptor binding in patients with Huntington's disease and other choreas. A PET study., Brain, Vol: 118 ( Pt 3), Pages: 689-696, ISSN: 0006-8950

We have used PET to study striatal D1 and D2 receptor binding in 10 patients with either the choreic or akinetic-rigid variants of Huntington's disease and in three patients with other causes of chorea. Background rigidity and bradykinesia in choreic patients were scored with a four-point scale. PET studies showed a severe and parallel reduction of both striatal D1 and D2 receptor binding in Huntington's disease patients irrespective of their predominant phenotype (mean reduction 60%). Huntington's disease patients with rigidity showed more pronounced reduction of striatal D1 and D2 binding compared with those without rigidity. A case of chorea associated with systemic lupus erythematosus had normal D2 binding. These results suggest that the presence of chorea per se may not be determined by alterations in striatal dopamine receptor binding, but that rigidity in Huntington's disease is associated with severe striatal D1 and D2 receptor loss.

Journal article

PREVETT MC, LAMMERTSMA AA, BROOKS DJ, CUNNINGHAM VJ, FISH DR, DUNCAN JSet al., 1995, BENZODIAZEPINE-GABA(A) RECEPTOR-BINDING DURING ABSENCE SEIZURES, EPILEPSIA, Vol: 36, Pages: 592-599, ISSN: 0013-9580

Journal article

TURJANSKI N, WEEKS R, DOLAN R, HARDING AE, BROOKS DJet al., 1995, STRIATAL D-1 AND D-2 RECEPTOR-BINDING IN PATIENTS WITH HUNTINGTONS-DISEASE AND OTHER CHOREAS - A PET STUDY, BRAIN, Vol: 118, Pages: 689-696, ISSN: 0006-8950

Journal article

CEBALLOSBAUMAN AO, PASSINGHAM RE, MARSDEN CD, BROOKS DJet al., 1995, MOTOR REORGANIZATION IN ACQUIRED HEMIDYSTONIA, ANNALS OF NEUROLOGY, Vol: 37, Pages: 746-757, ISSN: 0364-5134

Journal article

OPACKAJUFFRY J, BROOKS DJ, 1995, L-DIHYDROXYPHENYLALANINE AND ITS DECARBOXYLASE - NEW IDEAS ON THEIR NEUROREGULATORY ROLES, MOVEMENT DISORDERS, Vol: 10, Pages: 241-249, ISSN: 0885-3185

Journal article

ABRAHAMS S, LEIGH PN, KEW JJM, GOLDSTEIN LH, LLOYD CML, BROOKS DJet al., 1995, A POSITRON EMISSION TOMOGRAPHY STUDY OF FRONTAL-LOBE FUNCTION (VERBAL FLUENCY) IN AMYOTROPHIC-LATERAL-SCLEROSIS, 5th International Symposium on MND/ALS, Publisher: ELSEVIER SCIENCE BV, Pages: 44-46, ISSN: 0022-510X

Conference paper

Abrahams S, Goldstein LH, Lloyd CM, Brooks DJ, Leigh PNet al., 1995, Cognitive deficits in non-demented amyotrophic lateral sclerosis patients: a neuropsychological investigation., J Neurol Sci, Vol: 129 Suppl, Pages: 54-55, ISSN: 0022-510X

Journal article

Abrahams S, Leigh PN, Kew JJ, Goldstein LH, Lloyd CM, Brooks DJet al., 1995, A positron emission tomography study of frontal lobe function (verbal fluency) in amyotrophic lateral sclerosis., J Neurol Sci, Vol: 129 Suppl, Pages: 44-46, ISSN: 0022-510X

Positron emission tomography (PET) was used to investigate the location of cerebral cortical and subcortical abnormalities in non-demented patients with amyotrophic lateral sclerosis (ALS). Involvement of the frontal lobes was investigated with a task of executive frontal lobe function (verbal fluency/word generation), using a PET activation paradigm. Two groups of ALS patients defined by the presence or absence of cognitive impairment were tested. ALS patients who had cognitive impairments showed a region of cortical and subcortical dysfunction which extended across a wide area of the frontal lobes, and included the insular cortex and thalamic nuclear complex. These findings support the notion that extra-motor involvement is relatively common in ALS and broadens concepts of selective vulnerability in ALS.

Journal article

ABRAHAMS S, GOLDSTEIN LH, LLOYD CM, BROOKS DJ, LEIGH PNet al., 1995, COGNITIVE DEFICITS IN NONDEMENTED AMYOTROPHIC-LATERAL-SCLEROSIS PATIENTS - A NEUROPSYCHOLOGICAL INVESTIGATION, 5th International Symposium on MND/ALS, Publisher: ELSEVIER SCIENCE BV, Pages: 54-55, ISSN: 0022-510X

Conference paper

RINNE JO, BURN DJ, MATHIAS CJ, QUINN NP, MARSDEN CD, BROOKS DJet al., 1995, POSITRON EMISSION TOMOGRAPHY STUDIES ON THE DOPAMINERGIC SYSTEM AND STRIATAL OPIOID BINDING IN THE OLIVOPONTOCEREBELLAR ATROPHY VARIANT OF MULTIPLE SYSTEM ATROPHY, ANNALS OF NEUROLOGY, Vol: 37, Pages: 568-573, ISSN: 0364-5134

Journal article

PLAYFORD ED, BRITTON TC, THOMPSON PD, BROOKS DJ, FINDLEY LJ, MARSDEN CDet al., 1995, EXACERBATION OF POSTURAL TREMOR WITH EMERGENCE OF PARKINSONISM AFTER TREATMENT WITH NEUROLEPTIC DRUGS, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 58, Pages: 487-489, ISSN: 0022-3050

Journal article

WILLS AJ, JENKINS IH, THOMPSON PD, FINDLEY LJ, BROOKS DJet al., 1995, A POSITRON EMISSION TOMOGRAPHY STUDY OF CEREBRAL ACTIVATION-ASSOCIATED WITH ESSENTIAL AND WRITING TREMOR, ARCHIVES OF NEUROLOGY, Vol: 52, Pages: 299-305, ISSN: 0003-9942

Journal article

CEBALLOSBAUMANN AO, PASSINGHAM RE, WARNER T, PLAYFORD ED, MARSDEN CD, BROOKS DJet al., 1995, OVERACTIVE PREFRONTAL AND UNDERACTIVE MOTOR CORTICAL AREAS IN IDIOPATHIC DYSTONIA, ANNALS OF NEUROLOGY, Vol: 37, Pages: 363-372, ISSN: 0364-5134

Journal article

BROOKS DJ, 1995, PARKINSONS-DISEASE - A SINGLE CLINICAL ENTITY, QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS, Vol: 88, Pages: 81-91, ISSN: 0033-5622

Journal article

PREVETT MC, LAMMERTSMA AA, BROOKS DJ, BARTENSTEIN PA, PATSALOS PN, FISH DR, DUNCAN JSet al., 1995, BENZODIAZEPINE-GABA(A) RECEPTORS IN IDIOPATHIC GENERALIZED EPILEPSY MEASURED WITH [C-11] FLUMAZENIL AND POSITRON EMISSION TOMOGRAPHY, EPILEPSIA, Vol: 36, Pages: 113-121, ISSN: 0013-9580

Journal article

MENZA MA, MARK MH, BURN DJ, BROOKS DJet al., 1995, PERSONALITY-CORRELATES OF [F-18] DOPA STRIATAL UPTAKE - RESULTS OF POSITRON-EMISSION TOMOGRAPHY IN PARKINSONS-DISEASE, JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES, Vol: 7, Pages: 176-179, ISSN: 0895-0172

Journal article

Mathias CJ, Senard JM, Valeta P, Durrten G, Mathias CJ, Mathias CJ, Frankel L, Mathias CJ, Robertson D, Hollister AS, Biaggioni I, Mathias CJ, Armstrong E, Browse N, Mathias CJ, Bannister R, Cortelli P, Mathias CT, Christensen NJ, Frankel HL, Brooks DJ, Redmond S, Mathias CJ, Wieling W, Van Lieshout JJ, Van Leeuwen AM, Smith GDPet al., 1995, Orthostatic hypotension: Causes, mechanisms, and influencing factors, Neurology, Vol: 45, Pages: S6-S11, ISSN: 0028-3878

Blood pressure homeostasis is particularly challenged by moving to an upright position.The autonomic nervous system, structural factors, infravascular volume, and circulating and local hormones influence the body's response to a change in posture. Disorders of the autonomic nervous system can result in orthostatic hypotension. Both neurogenic and nonneurogenic disorders can contribute, and distinguishing between the two causes is important for both diagnosis and management. It is also important to recognize various factors in daily life that influence orthostatic hypotension. Copyright © 1995 American Academy of Neurology.

Journal article

Abrahams S, Leigh PN, Kew JJM, Goldstein LH, Lloyd CML, Brooks DJet al., 1995, A positron emission tomography study of frontal lobe function (verbal fluency) in amyotrophic lateral sclerosis, Pages: 44-46, ISSN: 0022-510X

Positron emission tomography (PET) was used to investigate the location of cerebral cortical and subcortical abnormalities in non-demented patients with amyotrophic lateral sclerosis (ALS). Involvement of the frontal lobes was investigated with a task of executive frontal lobe function (verbal fluency/word generation), using a PET activation paradigm. Two groups of ALS patients defined by the presence or absence of cognitive impairment were tested. ALS patients who had cognitive impairments showed a region of cortical and subcortical dysfunction which extended across a wide area of the frontal lobes, and included the insular cortex and thalamic nuclear complex. These findings support the notion that extra-motor involvement is relatively common in ALS and broadens concepts of selective vulnerability in ALS. © 1995 Elsevier Science B.V. All rights reserved.

Conference paper

Abrahams S, Goldstein LH, Lloyd CM, Brooks DJ, Leigh PNet al., 1995, Cognitive deficits in non-demented amyotrophic lateral sclerosis patients: a neuropsychological investigation, Pages: 54-55, ISSN: 0022-510X

  • Cite
  • Citations: 35
Conference paper

BROOKS DJ, 1995, THE ROLE OF THE BASAL GANGLIA IN MOTOR CONTROL - CONTRIBUTIONS FROM PET, JOURNAL OF THE NEUROLOGICAL SCIENCES, Vol: 128, Pages: 1-13, ISSN: 0022-510X

Journal article

JAHANSHAHI M, JENKINS H, BROWN RG, MARSDEN C, BROOKS DJ, PASSINGHAM REet al., 1995, SELF-INITIATED VS EXTERNALLY-TRIGGERED ACTIONS - THE EFFECTS OF STIMULUS PREDICTABILITY STUDIED WITH POSITRON EMISSION TOMOGRAPHY, JOURNAL OF PSYCHOPHYSIOLOGY, Vol: 9, Pages: 177-178, ISSN: 0269-8803

Journal article

TURJANSKI N, WEEKS R, SAWLE GV, BROOKS DJet al., 1995, PET studies of the dopaminergic and opioid function in dopa-responsive dystonic syndromes and Tourette's syndrome, International Symposium on Age-Related Monoamine-Dependent Disorders and Their Modulation by Gene and Gender/20 Anniversary Symposium of the Segawa-Neurological-Clinic-for-Children, Publisher: KARGER, Pages: 77-86

Conference paper

Brooks DJ, Torjanski N, Burn DJ, 1995, Ropinirole in the symptomatic treatment of Parkinson's disease, JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT, Pages: 231-238, ISSN: 0303-6995

Journal article

Piccini P, Turjanski N, Brooks DJ, 1995, PET studies of the striatal dopaminergic system in Parkinson's disease (PD), JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT, Pages: 123-131, ISSN: 0303-6995

Journal article

KEW JJM, RIDDING MC, ROTHWELL JC, PASSINGHAM RE, LEIGH PN, SOORIAKUMARAN S, FRACKOWIAK RSJ, BROOKS DJet al., 1994, REORGANIZATION OF CORTICAL BLOOD-FLOW AND TRANSCRANIAL MAGNETIC STIMULATION MAPS IN HUMAN-SUBJECTS AFTER UPPER-LIMB AMPUTATION, JOURNAL OF NEUROPHYSIOLOGY, Vol: 72, Pages: 2517-2524, ISSN: 0022-3077

Journal article

ANDERSON TJ, JENKINS IH, BROOKS DJ, HAWKEN MB, FRACKOWIAK RSJ, KENNARD Cet al., 1994, CORTICAL CONTROL OF SACCADES AND FIXATION IN MAN - A PET STUDY, BRAIN, Vol: 117, Pages: 1073-1084, ISSN: 0006-8950

Journal article

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