Publications
215 results found
Xiao B, Sanders MJ, Carmena D, et al., 2013, Structural basis of AMPK regulation by small molecule activators, NATURE COMMUNICATIONS, Vol: 4, ISSN: 2041-1723
- Author Web Link
- Cite
- Citations: 377
Wan X, Huo Y, Johns M, et al., 2013, 5′-AMP-Activated Protein Kinase-Activating Transcription Factor 1 Cascade Modulates Human Monocyte-Derived Macrophages to Atheroprotective Functions in Response to Heme or Metformin, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol: 33, Pages: 2470-2480, ISSN: 1079-5642
- Author Web Link
- Cite
- Citations: 35
Lallet-Daher H, Wiel C, Gitenay D, et al., 2013, Potassium Channel KCNA1 Modulates Oncogene-Induced Senescence and Transformation, CANCER RESEARCH, Vol: 73, Pages: 5253-5265, ISSN: 0008-5472
- Author Web Link
- Cite
- Citations: 36
Ruderman NB, Carling D, Prentki M, et al., 2013, AMPK, insulin resistance, and the metabolic syndrome, JOURNAL OF CLINICAL INVESTIGATION, Vol: 123, Pages: 2764-2772, ISSN: 0021-9738
- Author Web Link
- Cite
- Citations: 601
Zhao J, Carling D, Wang Z, et al., 2013, Loss of CaMKKβ attenuates endotoxin induced hypotension, Spring Meeting for Clinician Scientists in Training, Publisher: ELSEVIER SCIENCE INC, Pages: 119-119, ISSN: 0140-6736
Johns M, Carling D, Piper EL, et al., 2012, An Adenosine Monophosphate Activated Protein Kinase / Activating Transcription Factor-1 Cascade Initiates Commitment to Mhem Atheroprotective Macrophages in Response to Heme or Metformin, CIRCULATION, Vol: 126, ISSN: 0009-7322
Laine R, Stuckey DW, Manning H, et al., 2012, Fluorescence Lifetime Readouts of Troponin-C-Based Calcium FRET Sensors: A Quantitative Comparison of CFP and mTFP1 as Donor Fluorophores, PLOS ONE, Vol: 7, ISSN: 1932-6203
- Author Web Link
- Cite
- Citations: 20
Carling D, Thornton C, Woods A, et al., 2012, AMP-activated protein kinase: new regulation, new roles?, BIOCHEMICAL JOURNAL, Vol: 445, Pages: 11-27, ISSN: 0264-6021
- Author Web Link
- Cite
- Citations: 299
Oliveira SM, Zhang Y-H, Solis RS, et al., 2012, AMP-Activated Protein Kinase Phosphorylates Cardiac Troponin I and Alters Contractility of Murine Ventricular Myocytes, CIRCULATION RESEARCH, Vol: 110, Pages: 1192-1201, ISSN: 0009-7330
- Author Web Link
- Cite
- Citations: 62
Tsuchiya Y, Denison FC, Heath RB, et al., 2012, 5′-AMP-activated protein kinase is inactivated by adrenergic signalling in adult cardiac myocytes, BIOSCIENCE REPORTS, Vol: 32, Pages: 197-209, ISSN: 0144-8463
- Author Web Link
- Cite
- Citations: 11
Fritah A, Steel JH, Parker N, et al., 2012, Absence of RIP140 Reveals a Pathway Regulating glut4-Dependent Glucose Uptake in Oxidative Skeletal Muscle through UCP1-Mediated Activation of AMPK, PLOS ONE, Vol: 7, ISSN: 1932-6203
- Author Web Link
- Open Access Link
- Cite
- Citations: 24
Woods A, Leiper JM, Carling D, 2012, The role of ATM in response to metformin treatment and activation of AMPK., Nature Genetics, Vol: 44, Pages: 360-361
Denison FC, Smith LB, Muckett PJ, et al., 2011, LKB1 Is an Essential Regulator of Spermatozoa Release during Spermiation in the Mammalian Testis, PLOS ONE, Vol: 6, ISSN: 1932-6203
- Author Web Link
- Cite
- Citations: 24
Mayer FV, Heath R, Underwood E, et al., 2011, ADP regulates SNF1, the Saccharomyces cerevisiae homolog of AMP-activated protein kinase., Cell Metab, Vol: 14, Pages: 707-714
The SNF1 protein kinase complex plays an essential role in regulating gene expression in response to the level of extracellular glucose in budding yeast. SNF1 shares structural and functional similarities with mammalian AMP-activated protein kinase. Both kinases are activated by phosphorylation on a threonine residue within the activation loop segment of the catalytic subunit. Here we show that ADP is the long-sought metabolite that activates SNF1 in response to glucose limitation by protecting the enzyme against dephosphorylation by Glc7, its physiologically relevant protein phosphatase. We also show that the regulatory subunit of SNF1 has two ADP binding sites. The tighter site binds AMP, ADP, and ATP competitively with NADH, whereas the weaker site does not bind NADH, but is responsible for mediating the protective effect of ADP on dephosphorylation. Mutagenesis experiments suggest that the general mechanism by which ADP protects against dephosphorylation is strongly conserved between SNF1 and AMPK.
Hardie DG, Carling D, Gamblin SJ, 2011, AMP-activated protein kinase: also regulated by ADP?, TRENDS IN BIOCHEMICAL SCIENCES, Vol: 36, Pages: 470-477, ISSN: 0968-0004
- Author Web Link
- Cite
- Citations: 137
Carling D, Mayer FV, Sanders MJ, et al., 2011, AMP-activated protein kinase: nature's energy sensor, NATURE CHEMICAL BIOLOGY, Vol: 7, Pages: 512-518, ISSN: 1552-4450
- Author Web Link
- Cite
- Citations: 318
Xiao B, Sanders MJ, Underwood E, et al., 2011, Structure of mammalian AMPK and its regulation by ADP, NATURE, Vol: 472, Pages: 230-233, ISSN: 0028-0836
- Author Web Link
- Cite
- Citations: 655
Claret M, Smith MA, Knauf C, et al., 2011, Deletion of <i>Lkb1</i> in Pro-Opiomelanocortin Neurons Impairs Peripheral Glucose Homeostasis in Mice, DIABETES, Vol: 60, Pages: 735-745, ISSN: 0012-1797
- Author Web Link
- Cite
- Citations: 44
Woods A, Heslegrave AJ, Muckett PJ, et al., 2011, LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice, BIOCHEMICAL JOURNAL, Vol: 434, Pages: 49-60, ISSN: 0264-6021
- Author Web Link
- Cite
- Citations: 62
Thorton C, Bright N, Sastre M, et al., 2011, AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to β-amyloid exposure, Biochemical Journal, Vol: 434, Pages: 503-512
Bungard D, Fuerth BJ, Zeng P-Y, et al., 2010, Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation, SCIENCE, Vol: 329, Pages: 1201-1205, ISSN: 0036-8075
- Author Web Link
- Cite
- Citations: 275
Lopez M, Varela L, Vazquez MJ, et al., 2010, Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance, NATURE MEDICINE, Vol: 16, Pages: 1001-U97, ISSN: 1078-8956
- Author Web Link
- Cite
- Citations: 516
Beall C, Piipari K, Al-Qassab H, et al., 2010, Loss of AMP-activated protein kinase α2 subunit in mouse β-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia, BIOCHEMICAL JOURNAL, Vol: 429, Pages: 323-333, ISSN: 0264-6021
- Author Web Link
- Cite
- Citations: 48
Piipari K, Beall C, Al-Qassab H, et al., 2010, Key Role of AMP-Activated Protein Kinase in Pancreatic Beta Cell Glucose-Sensing and Whole Body Glucose Homeostasis, 92nd Meeting and Expo of the Endocrine Society (ENDO 2010), Publisher: ENDOCRINE SOC, Pages: S810-S810, ISSN: 0163-769X
Stahmann N, Woods A, Spengler K, et al., 2010, Activation of AMP-activated Protein Kinase by Vascular Endothelial Growth Factor Mediates Endothelial Angiogenesis Independently of Nitric-oxide Synthase, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 285, Pages: 10638-10652, ISSN: 0021-9258
- Author Web Link
- Cite
- Citations: 75
Garcia-Garcia C, Fumarola C, Navaratnam N, et al., 2010, AMPK-independent down-regulation of cFLIP and sensitization to TRAIL-induced apoptosis by AMPK activators, BIOCHEMICAL PHARMACOLOGY, Vol: 79, Pages: 853-863, ISSN: 0006-2952
- Author Web Link
- Cite
- Citations: 20
Carling D, 2010, The role of the AMPK cascade in regulating energy metabolism, ENDOCRINE JOURNAL, Vol: 57, Pages: S250-S250, ISSN: 0918-8959
Humbert N, Navaratnam N, Augert A, et al., 2010, Regulation of ploidy and senescence by the AMPK-related kinase NUAK1, EMBO J, Vol: 29, Pages: 376-386
Senescence is an irreversible cell-cycle arrest that is elicited by a wide range of factors, including replicative exhaustion. Emerging evidences suggest that cellular senescence contributes to ageing and acts as a tumour suppressor mechanism. To identify novel genes regulating senescence, we performed a loss-of-function screen on normal human diploid fibroblasts. We show that downregulation of the AMPK-related protein kinase 5 (ARK5 or NUAK1) results in extension of the cellular replicative lifespan. Interestingly, the levels of NUAK1 are upregulated during senescence whereas its ectopic expression triggers a premature senescence. Cells that constitutively express NUAK1 suffer gross aneuploidies and show diminished expression of the genomic stability regulator LATS1, whereas depletion of NUAK1 with shRNA exerts opposite effects. Interestingly, a dominant-negative form of LATS1 phenocopies NUAK1 effects. Moreover, we show that NUAK1 phosphorylates LATS1 at S464 and this has a role in controlling its stability. In summary, our work highlights a novel role for NUAK1 in the control of cellular senescence and cellular ploidy. The EMBO Journal (2010) 29, 376-386. doi: 10.1038/emboj.2009.342; Published online 19 November 2009
Selman C, Tullet JMA, Wieser D, et al., 2009, Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span, SCIENCE, Vol: 326, Pages: 140-144, ISSN: 0036-8075
- Author Web Link
- Cite
- Citations: 837
Renz B, Davies JK, Carling D, et al., 2009, Determination of AMP-activated protein kinase phosphorylation sites in recombinant protein expressed using the pET28a vector: A cautionary tale, PROTEIN EXPRESSION AND PURIFICATION, Vol: 66, Pages: 181-184, ISSN: 1046-5928
- Author Web Link
- Cite
- Citations: 3
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.