Publications
215 results found
Carling D, Woods A, Thornton C, et al., 1997, Molecular characterization of the AMP-activated protein kinase and its role in cellular metabolism, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 25, Pages: 1224-1228, ISSN: 0300-5127
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- Citations: 9
Cheung PCF, Carling D, 1997, Interaction of AMP-activated protein kinase subunits in the heterotrimeric complex and with their yeast homologues, 662nd Meeting of the Biochemical-Society, Publisher: PORTLAND PRESS, Pages: S668-S668, ISSN: 0300-5127
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- Citations: 2
Thornton C, Snowden MA, Carling D, 1997, Identification of a novel AMPKβ subunit that is highly expressed in skeletal muscle, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 25, Pages: S667-S667, ISSN: 0300-5127
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- Citations: 3
Hardie DG, Carling D, 1997, The AMP-activated protein kinase - Fuel gauge of the mammalian cell?, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 246, Pages: 259-273, ISSN: 0014-2956
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- Citations: 1098
Sprenkle AB, Davies SP, Carling D, et al., 1997, Identification of Raf-1 Ser(621) kinase activity from NIH 3T3 cells as AMP-activated protein kinase, FEBS LETTERS, Vol: 403, Pages: 254-258, ISSN: 0014-5793
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- Citations: 53
Marley AE, Sullivan JE, Carling D, et al., 1996, Biochemical characterization and deletion analysis of recombinant human protein phosphatase 2C alpha, BIOCHEMICAL JOURNAL, Vol: 320, Pages: 801-806, ISSN: 0264-6021
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- Citations: 74
Woods A, Salt I, Scott J, et al., 1996, The alpha 1 and alpha 2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro, FEBS LETTERS, Vol: 397, Pages: 347-351, ISSN: 0014-5793
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- Citations: 225
Hawley SA, Davison M, Woods A, et al., 1996, Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 271, Pages: 27879-27887, ISSN: 0021-9258
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- Citations: 986
Woods A, Cheung PCF, Smith FC, et al., 1996, Characterization of AMP-activated protein kinase beta and gamma subunits - Assembly of the heterotrimeric complex in vitro, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 271, Pages: 10282-10290, ISSN: 0021-9258
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- Citations: 214
HAWLEY SA, SELBERT MA, GOLDSTEIN EG, et al., 1995, 5'-AMP ACTIVATES THE AMP-ACTIVATED PROTEIN-KINASE CASCADE AND CA2+/CALMODULIN ACTIVATES THE CALMODULIN-DEPENDENT PROTEIN-KINASE-I CASCADE, VIA 3 INDEPENDENT MECHANISMS, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 270, Pages: 27186-27191, ISSN: 0021-9258
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- Citations: 354
VERHOEVEN AJM, WOODS A, BRENNAN CH, et al., 1995, THE AMP-ACTIVATED PROTEIN-KINASE GENE IS HIGHLY EXPRESSED IN RAT SKELETAL-MUSCLE - ALTERNATIVE SPLICING AND TISSUE DISTRIBUTION OF THE MESSENGER-RNA, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 228, Pages: 236-243, ISSN: 0014-2956
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- Citations: 57
BERI RK, MARLEY AE, SEE CG, et al., 1994, MOLECULAR-CLONING, EXPRESSION AND CHROMOSOMAL LOCALIZATION OF HUMAN AMP-ACTIVATED, FEBS LETTERS, Vol: 356, Pages: 117-121, ISSN: 0014-5793
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- Citations: 32
Hardie DG, Carling D, Halford N, 1994, Roles of the Snf1/Rkin1/AMP-activated protein kinase family in the response to environmental and nutritional stress., Semin Cell Biol, Vol: 5, Pages: 409-416, ISSN: 1043-4682
The AMP-activated protein kinase (AMPK) inhibits several biosynthetic pathways in mammals, and is activated in response to stresses which cause ATP depletion, e.g. heat shock. This system may therefore protect cells against environmental stress by switching off biosynthesis (i.e. growth) to conserve ATP. Recent biochemical and molecular genetic studies have shown that AMPK is closely related to the SNF1 gene product from Saccharomyces cerevisiae, and its homologues in higher plants. SNF1 is required for the response to starvation for glucose. Thus the novel function of providing protection against environmental stress may have evolved from a more ancient response to nutritional stress.
SULLIVAN JE, BROCKLEHURST KJ, MARLEY AE, et al., 1994, INHIBITION OF LIPOLYSIS AND LIPOGENESIS IN ISOLATED RAT ADIPOCYTES WITH AICAR, A CELL-PERMEABLE ACTIVATOR OF AMP-ACTIVATED PROTEIN-KINASE, FEBS LETTERS, Vol: 353, Pages: 33-36, ISSN: 0014-5793
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- Citations: 413
WOODS A, MUNDAY MR, SCOTT J, et al., 1994, YEAST SNF1 IS FUNCTIONALLY RELATED TO MAMMALIAN AMP-ACTIVATED PROTEIN-KINASE AND REGULATES ACETYL-COA CARBOXYLASE IN-VIVO, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 269, Pages: 19509-19515, ISSN: 0021-9258
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- Citations: 332
DAVIES SP, HAWLEY SA, WOODS A, et al., 1994, PURIFICATION OF THE AMP-ACTIVATED PROTEIN-KINASE ON ATP-GAMMA-SEPHAROSE AND ANALYSIS OF ITS SUBUNIT STRUCTURE, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 223, Pages: 351-357, ISSN: 0014-2956
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- Citations: 129
VERHOEVEN AJM, CARLING D, JANSEN H, 1994, HEPATIC LIPASE GENE IS TRANSCRIBED IN RAT ADRENALS INTO A TRUNCATED MESSENGER-RNA, JOURNAL OF LIPID RESEARCH, Vol: 35, Pages: 966-975, ISSN: 0022-2275
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- Citations: 25
SULLIVAN JE, CAREY F, CARLING D, et al., 1994, CHARACTERIZATION OF 5'-AMP-ACTIVATED PROTEIN-KINASE IN HUMAN LIVER USING SPECIFIC PEPTIDE-SUBSTRATES AND THE EFFECTS OF 5'-AMP ANALOGS ON ENZYME-ACTIVITY, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 200, Pages: 1551-1556, ISSN: 0006-291X
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- Citations: 77
CARLING D, AGUAN K, WOODS A, et al., 1994, MAMMALIAN AMP-ACTIVATED PROTEIN-KINASE IS HOMOLOGOUS TO YEAST AND PLANT PROTEIN-KINASES INVOLVED IN THE REGULATION OF CARBON METABOLISM, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 269, Pages: 11442-11448, ISSN: 0021-9258
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- Citations: 201
DAVIES SP, CARLING D, MUNDAY MR, et al., 1992, DIURNAL RHYTHM OF PHOSPHORYLATION OF RAT-LIVER ACETYL COA CARBOXYLASE BY THE AMP-ACTIVATED PROTEIN-KINASE, DEMONSTRATED USING FREEZE-CLAMPING - EFFECTS OF HIGH-FAT DIETS, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 203, Pages: 615-623, ISSN: 0014-2956
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- Citations: 142
Carling D, Clarke PR, Grahame Hardie D, 1991, [29] Adenosine monophosphate-activated protein kinase: Hydroxymethylglutaryl-CoA reductase kinase, Methods in Enzymology, Publisher: Elsevier, Pages: 362-371
CARLING D, CLARKE PR, HARDIE DG, 1991, ADENOSINE MONOPHOSPHATE-ACTIVATED PROTEIN-KINASE - HYDROXYMETHYLGLUTARYL-COA REDUCTASE KINASE, METHODS IN ENZYMOLOGY, Vol: 200, Pages: 362-371, ISSN: 0076-6879
DAVIES SP, CARLING D, HARDIE DG, 1989, TISSUE DISTRIBUTION OF THE AMP-ACTIVATED PROTEIN-KINASE, AND LACK OF ACTIVATION BY CYCLIC-AMP-DEPENDENT PROTEIN-KINASE, STUDIED USING A SPECIFIC AND SENSITIVE PEPTIDE ASSAY, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 186, Pages: 123-128, ISSN: 0014-2956
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- Citations: 390
CARLING D, CLARKE PR, ZAMMIT VA, et al., 1989, PURIFICATION AND CHARACTERIZATION OF THE AMP-ACTIVATED PROTEIN-KINASE - COPURIFICATION OF ACETYL-COA CARBOXYLASE KINASE AND 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE KINASE-ACTIVITIES, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 186, Pages: 129-136, ISSN: 0014-2956
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- Citations: 347
CARLING D, HARDIE DG, 1989, THE SUBSTRATE AND SEQUENCE SPECIFICITY OF THE AMP-ACTIVATED PROTEIN-KINASE - PHOSPHORYLATION OF GLYCOGEN-SYNTHASE AND PHOSPHORYLASE-KINASE, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 1012, Pages: 81-86, ISSN: 0006-3002
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- Citations: 251
GARTON AJ, CAMPBELL DG, CARLING D, et al., 1989, PHOSPHORYLATION OF BOVINE HORMONE-SENSITIVE LIPASE BY THE AMP-ACTIVATED PROTEIN-KINASE - A POSSIBLE ANTILIPOLYTIC MECHANISM, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 179, Pages: 249-254, ISSN: 0014-2956
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- Citations: 235
HAYSTEAD TAJ, SIM ATR, CARLING D, et al., 1989, EFFECTS OF THE TUMOR PROMOTER OKADAIC ACID ON INTRACELLULAR PROTEIN-PHOSPHORYLATION AND METABOLISM, NATURE, Vol: 337, Pages: 78-81, ISSN: 0028-0836
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- Citations: 864
HARDIE DG, CARLING D, SIM ATR, 1989, THE AMP-ACTIVATED PROTEIN-KINASE - A MULTISUBSTRATE REGULATOR OF LIPID-METABOLISM, TRENDS IN BIOCHEMICAL SCIENCES, Vol: 14, Pages: 20-23, ISSN: 0968-0004
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- Citations: 170
MUNDAY MR, CARLING D, HARDIE DG, 1988, NEGATIVE INTERACTIONS BETWEEN PHOSPHORYLATION OF ACETYL-COA CARBOXYLASE BY THE CYCLIC AMP-DEPENDENT AND AMP-ACTIVATED PROTEIN-KINASES, FEBS LETTERS, Vol: 235, Pages: 144-148, ISSN: 0014-5793
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- Citations: 37
MUNDAY MR, CAMPBELL DG, CARLING D, et al., 1988, IDENTIFICATION BY AMINO-ACID SEQUENCING OF 3 MAJOR REGULATORY PHOSPHORYLATION SITES ON RAT ACETYL-COA CARBOXYLASE, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 175, Pages: 331-338, ISSN: 0014-2956
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- Citations: 234
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