Imperial College London
Alternate

ProfessorDavidCarling

Faculty of Medicine, Institute of Clinical Sciences

Professor of Biochemistry
 
 
 
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Contact

 

+44 (0)7590 250 559david.carling

 
 
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Location

 

2.14DLMS BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Carling:2023:10.1016/j.celrep.2023.112396,
author = {Carling, D and Bevan, C and Leach, D and Fets, L and Woods, A and Pollard, A and Whilding, C and Penfold, L and Navarro-Pascual, E and Muckett, P and Montoya, A and Mokochinski, J and Constantin, T and Hall, Z and Dore, M and Nikitin, Y},
doi = {10.1016/j.celrep.2023.112396},
journal = {Cell Reports},
pages = {1--21},
title = {AMPK activation protects against prostate cancer by inducing a catabolic cellular state},
url = {http://dx.doi.org/10.1016/j.celrep.2023.112396},
volume = {42},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Emerging evidence indicates that metabolic dysregulation drives prostate cancer (PCa) progression and metastasis. AMP-activated protein kinase (AMPK) is a master regulator of metabolism, although its role in PCa remains unclear. Here, we show that genetic and pharmacological activation of AMPK provides a protective effect on PCa progression in vivo. We show that AMPK activation induces PGC1α expression, leading to catabolic metabolic reprogramming of PCa cells. This catabolic state is characterized by increased mitochondrial gene expression, increased fatty acid oxidation, decreased lipogenic potential, decreased cell proliferation, and decreased cell invasiveness. Together, these changes inhibit PCa disease progression. Additionally, we identify a gene network involved in cell cycle regulation that is inhibited by AMPK activation. Strikingly, we show a correlation between this gene network and PGC1α gene expression in human PCa. Taken together, our findings support the use of AMPK activators for clinical treatment of PCa to improve patient outcome.
AU  - Carling,D
AU  - Bevan,C
AU  - Leach,D
AU  - Fets,L
AU  - Woods,A
AU  - Pollard,A
AU  - Whilding,C
AU  - Penfold,L
AU  - Navarro-Pascual,E
AU  - Muckett,P
AU  - Montoya,A
AU  - Mokochinski,J
AU  - Constantin,T
AU  - Hall,Z
AU  - Dore,M
AU  - Nikitin,Y
DO  - 10.1016/j.celrep.2023.112396
EP  - 21
PY  - 2023///
SN  - 2211-1247
SP  - 1
TI  - AMPK activation protects against prostate cancer by inducing a catabolic cellular state
T2  - Cell Reports
UR  - http://dx.doi.org/10.1016/j.celrep.2023.112396
UR  - https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00407-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124723004072%3F
UR  - http://hdl.handle.net/10044/1/103728
VL  - 42
ER  -
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