Imperial College London
Alternate

ProfessorDavidCarling

Faculty of Medicine, Institute of Clinical Sciences

Professor of Biochemistry
 
 
 
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Contact

 

+44 (0)7590 250 559david.carling

 
 
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Location

 

2.14DLMS BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{McGlone:2023:10.1111/liv.15614,
author = {McGlone, ER and Siebert, M and Dore, M and Hope, DCD and Davies, I and Owen, B and Khoo, B and Goldin, R and Carling, D and Bloom, S and Le, Gall M and Tan, TM-M},
doi = {10.1111/liv.15614},
journal = {Liver International},
pages = {1890--1900},
title = {Sleeve gastrectomy causes weight-loss independent improvements in hepatic steatosis},
url = {http://dx.doi.org/10.1111/liv.15614},
volume = {43},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background and AimsSleeve gastrectomy (VSG) leads to improvement in hepatic steatosis, associated with weight loss. The aims of this study were to investigate whether VSG leads to weight-loss independent improvements in liver steatosis in mice with diet-induced obesity (DIO); and to metabolically and transcriptomically profile hepatic changes in mice undergoing VSG.MethodsMice with DIO were treated with VSG, sham surgery with subsequent food restriction to weight-match to the VSG group (Sham-WM), or sham surgery with return to unrestricted diet (Sham-Ad lib). Hepatic steatosis, glucose tolerance, insulin and glucagon resistance, and hepatic transcriptomics were investigated at the end of the study period and treatment groups were compared with mice undergoing sham surgery only (Sham-Ad lib).ResultsVSG led to much greater improvement in liver steatosis than Sham-WM (liver triglyceride mg/mg 2.5 ± 0.1, 2.1 ± 0.2, 1.6 ± 0.1 for Sham-AL, Sham-WM and VSG respectively; p = 0.003). Homeostatic model assessment of insulin resistance was improved following VSG only (51.2 ± 8.8, 36.3 ± 5.3, 22.3 ± 6.1 for Sham-AL, Sham-WM and VSG respectively; p = 0.03). The glucagon-alanine index, a measure of glucagon resistance, fell with VSG but was significantly increased in Sham-WM (9.8 ± 1.7, 25.8 ± 4.6 and 5.2 ± 1.2 in Sham Ad-lib, Sham-WM and VSG respectively; p = 0.0003). Genes downstream of glucagon receptor signalling which govern fatty acid synthesis (Acaca, Acacb, Me1, Acly, Fasn and Elovl6) were downregulated following VSG but upregulated in Sham-WM.ConclusionsChanges in glucagon sensitivity may contribute to weight-loss independent improvements in hepatic steatosis following VSG.
AU  - McGlone,ER
AU  - Siebert,M
AU  - Dore,M
AU  - Hope,DCD
AU  - Davies,I
AU  - Owen,B
AU  - Khoo,B
AU  - Goldin,R
AU  - Carling,D
AU  - Bloom,S
AU  - Le,Gall M
AU  - Tan,TM-M
DO  - 10.1111/liv.15614
EP  - 1900
PY  - 2023///
SN  - 1478-3223
SP  - 1890
TI  - Sleeve gastrectomy causes weight-loss independent improvements in hepatic steatosis
T2  - Liver International
UR  - http://dx.doi.org/10.1111/liv.15614
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000991490400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://onlinelibrary.wiley.com/doi/10.1111/liv.15614
UR  - http://hdl.handle.net/10044/1/107330
VL  - 43
ER  -
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