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@article{Carling:2017:10.1016/j.ceb.2017.01.005,
author = {Carling, D},
doi = {10.1016/j.ceb.2017.01.005},
journal = {Current Opinion in Cell Biology},
pages = {31--37},
title = {AMPK signalling in health and disease},
url = {http://dx.doi.org/10.1016/j.ceb.2017.01.005},
volume = {45},
year = {2017}
}

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TY  - JOUR
AB  - In eukaryotic cells AMP-activated protein kinase (AMPK) plays a major role in regulating cellular energy balance. AMPK responds to changes in intracellular adenine nucleotide levels, being activated by an increase in AMP/ADP relative to ATP. Activation of AMPK increases the rate of catabolic (ATP-generating) pathways and decreases the rate of anabolic (ATP-utilising) pathways. In addition to its role in maintaining intracellular energy balance, AMPK regulates whole body energy metabolism. Given its key role in controlling energy homeostasis, AMPK has attracted widespread interest as a potential therapeutic target for metabolic diseases, including type 2 diabetes and, more recently, cancer. Here I review the regulation of AMPK and its potential as a target for therapeutic intervention in human disease.
AU  - Carling,D
DO  - 10.1016/j.ceb.2017.01.005
EP  - 37
PY  - 2017///
SN  - 1879-0410
SP  - 31
TI  - AMPK signalling in health and disease
T2  - Current Opinion in Cell Biology
UR  - http://dx.doi.org/10.1016/j.ceb.2017.01.005
UR  - http://www.ncbi.nlm.nih.gov/pubmed/28232179
UR  - http://hdl.handle.net/10044/1/45767
VL  - 45
ER  -

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