Publications
161 results found
Vichayanrat E, Low DA, Stuebner E, et al., 2014, The usefulness of 24 hour ambulatory blood pressure and heart rate monitoring (24hr-ABPM) in diagnosing orthostatic hypotension (OH) in patients with parkinsonian disorders, Joint Congress of European Neurology, Publisher: WILEY-BLACKWELL, Pages: 86-86, ISSN: 1351-5101
Asahina M, Mathias CJ, Katagiri A, et al., 2014, Sudomotor and Cardiovascular Dysfunction in Patients with Early Untreated Parkinson's Disease, JOURNAL OF PARKINSONS DISEASE, Vol: 4, Pages: 385-393, ISSN: 1877-7171
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- Citations: 16
Mawhinney C, Jones H, Joo CH, et al., 2013, Influence of Cold-Water Immersion on Limb and Cutaneous Blood Flow after Exercise, MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, Vol: 45, Pages: 2277-2285, ISSN: 0195-9131
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- Citations: 61
Low DA, 2013, The cerebovasculature: a smooth (muscle) operator?, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 591, Pages: 4959-4960, ISSN: 0022-3751
Pearson J, Kalsi KK, Stoehr EJ, et al., 2013, Erratum to: Haemodynamic responses to dehydration in the resting and exercising human leg (vol 113, pg 1499, 2013), EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, Vol: 113, Pages: 2431-2432, ISSN: 1439-6319
Vichayanrat E, Low DA, Asahina M, et al., 2013, L-DOPS and the treatment of neurogenic orthostatic hypotension, Future Neurology, Vol: 8, Pages: 381-397, ISSN: 1479-6708
L-threo-dihydroxyphenylserine (L-DOPS) is an oral prodrug that is converted to the sympathetic neurotransmitter noradrenaline through a single-step decarboxylation by the endogenous enzyme 3,4-dihydrophenylalanine decarboxylase. DOPS can provide an exogenous source of noradrenaline to adrenergic neurons that are involved in the maintenance of blood pressure. Impaired secretion of noradrenaline at the synaptic junction can result in neurogenic orthostatic hypotension and cause faints and falls. The safety and efficacy of DOPS has been evaluated in patients with neurogenic orthostatic hypotension caused by a variety of neurological conditions that can result in autonomic failure, such as Parkinson's disease, multiple system atrophy, pure autonomic failure and dopamine-hydroxylase deficiency. In this review, we include Phase II and III clinical trials undertaken that have examined the safety, efficacy and tolerability of DOPS in the treatment of neurogenic orthostatic hypotension. Drug mechanisms and pharmacology of the drug are also discussed. © 2013 Future Medicine Ltd.
Pearson J, Kalsi KK, Stoehr EJ, et al., 2013, Haemodynamic responses to dehydration in the resting and exercising human leg, EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, Vol: 113, Pages: 1499-1509, ISSN: 1439-6319
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- Citations: 12
Asahina M, Vichayanrat E, Low DA, et al., 2013, Autonomic dysfunction in parkinsonian disorders: assessment and pathophysiology, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 84, Pages: 674-680, ISSN: 0022-3050
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- Citations: 74
Idiaquez J, Fadic R, Verdugo R, et al., 2013, Pure autonomic failure with cold induced sweating, AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, Vol: 176, Pages: 98-100, ISSN: 1566-0702
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- Citations: 2
Stuebner E, Vichayanrat E, Low DA, et al., 2013, Twenty-four hour non-invasive ambulatory blood pressure and heart rate monitoring in Parkinson’s Disease, Frontiers in Neurology, Vol: 4, ISSN: 1664-2295
Mathias CJ, Iodice V, Low DA, et al., 2013, Treatment of orthostatic hypotension, Autonomic Failure, Publisher: Oxford University Press, Pages: 569-584
Mathias CJ, Low DA, Frankel HL, 2013, Autonomic disturbances in spinal cord lesions, Autonomic Failure, Publisher: Oxford University Press, Pages: 797-817
Lucas da Nóbrega AC, Low DA, Mathias CJ, 2013, Exercise-induced hypotension in autonomic disorders, Autonomic Failure, Publisher: Oxford University Press, Pages: 381-394
Asahina M, Low DA, Mathias CJ, et al., 2013, Skin temperature of the hand in multiple system atrophy and Parkinson's disease, PARKINSONISM & RELATED DISORDERS, Vol: 19, Pages: 560-562, ISSN: 1353-8020
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- Citations: 8
Low DA, Akhtar MA, Iodice V, et al., 2013, Hyperadrenergic activity and the Postural Tachycardia Syndrome (PoTS), Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB), Publisher: FEDERATION AMER SOC EXP BIOL, ISSN: 0892-6638
Seligman WH, Low DA, Asahina M, et al., 2013, Abnormal gastric myoelectrical activity in postural tachycardia syndrome, CLINICAL AUTONOMIC RESEARCH, Vol: 23, Pages: 73-80, ISSN: 0959-9851
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- Citations: 21
Nobrega ACL, Low DA, Mathias CJ, 2013, Exercise-Induced Hypotension in Autonomic Disorders, Autonomic Failure, Editors: Mathias, Bannister, Publisher: Oxford University Press, USA, ISBN: 9780192628503
Hagen EM, Low DA, Vichayanrat E, et al., 2012, 24-hour ambulatory blood pressure profiles in diabetic autonomic neuropathy, amyloid neuropathy and Holmes-Adie syndrome, 16th Congress of the European-Federation-of-Neurological-Societies (EFNS), Publisher: WILEY-BLACKWELL, Pages: 130-130, ISSN: 1351-5101
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- Citations: 1
Iodice V, Low D, Grahame R, et al., 2012, Postural tachycardia syndrome, joint hypermobility syndrome and Chiari type I malformation: clinical description and autonomic evaluation, 16th Congress of the European-Federation-of-Neurological-Societies (EFNS), Publisher: WILEY-BLACKWELL, Pages: 132-132, ISSN: 1351-5101
Vichayanrat E, Low D, Nilsen KB, et al., 2012, Quantitative cardiovascular autonomic function in patients with primary chronic autonomic failure, 16th Congress of the European-Federation-of-Neurological-Societies (EFNS), Publisher: WILEY-BLACKWELL, Pages: 125-125, ISSN: 1351-5101
Low DA, Vichayanrat E, Seligman W, et al., 2012, Electrogastrography in pure autonomic failure, 16th Congress of the European-Federation-of-Neurological-Societies (EFNS), Publisher: WILEY-BLACKWELL, Pages: 123-123, ISSN: 1351-5101
Asahina M, Low DA, Mathias CJ, et al., 2012, Is the "cold hands" sign useful in differentiating multiple system atrophy from Parkinson's disease?, 16th Congress of the European-Federation-of-Neurological-Societies (EFNS), Publisher: WILEY-BLACKWELL, Pages: 323-323, ISSN: 1351-5101
Iodice V, Low D, Mathias C, 2012, The effects of the somatostatin analogue, octreotide, on orthostasis before and after food ingestion, in the postural tachycardia syndrome, 16th Congress of the European-Federation-of-Neurological-Societies (EFNS), Publisher: WILEY-BLACKWELL, Pages: 47-47, ISSN: 1351-5101
Hagen EM, Low DA, Vichayanrat E, et al., 2012, Postural tachycardia syndrome (PoTS) and 24-hour ambulatory blood pressure and heart rate monitoring, 16th Congress of the European-Federation-of-Neurological-Societies (EFNS), Publisher: WILEY-BLACKWELL, Pages: 131-131, ISSN: 1351-5101
Stoehr EJ, Low DA, Nio AQX, et al., 2012, Left Ventricular Mechanics Following Ultra-endurance Exercise - Impact Of Dehydration, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 879-879, ISSN: 0195-9131
Mawhinney C, Jones H, Low DA, et al., 2012, The Influence of Cold Water Immersion on Limb and Cutaneous Blood Flows Following Exercise, MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, Vol: 44, Pages: 388-388, ISSN: 0195-9131
Mathias CJ, Low DA, Iodice V, et al., 2012, Investigation of autonomic disorders, Autonomic Failure, Editors: Mathias, Bannister, Publisher: Oxford University Press, USA, ISBN: 9780192628503
Mathias CJ, Low DA, Iodice V, et al., 2012, Postural tachycardia syndrome-current experience and concepts, NATURE REVIEWS NEUROLOGY, Vol: 8, Pages: 22-34, ISSN: 1759-4758
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- Citations: 162
Kwasnicki RM, Low DA, Wong C, et al., 2012, Investigating the feasibility of using objective motion data to assist the diagnosis and management of cardiovascular autonomic dysfunction, Pages: 137-137
Mathias CJ, Low DA, 2012, Autonomic Disturbances in Spinal Cord Injuries, Primer on the autonomic nervous system, Editors: Robertson, Biaggioni, Burnstock, Low, Paton, San Diego, CA, Publisher: Elsevier Academic Press, Pages: 505-510, ISBN: 9780125897624
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