Imperial College London
Dr David Low

DrDavidLow

Faculty of Medicine, Department of Surgery & Cancer

Honorary Senior Lecturer
 
 
 
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+44 (0)1519 046 244david.low

 
 
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Summary

 

Publications

Citation

BibTex format

@article{Dawson:2015:10.1111/micc.12196,
author = {Dawson, EA and Low, DA and Meeuwis, IH and Kerstens, FG and Atkinson, CL and Cable, NT and Green, DJ and Thijssen, DH},
doi = {10.1111/micc.12196},
journal = {Microcirculation},
pages = {276--284},
title = {Reproducibility of cutaneous vascular conductance responses to slow local heating assessed using seven-laser array probes},
url = {http://dx.doi.org/10.1111/micc.12196},
volume = {22},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE: Gradual local heating of the skin induces a largely NO-mediated vasodilatation. However, use of this assessment of microvascular health is limited because little is known about its reproducibility. METHODS: Healthy volunteers (n = 9) reported twice to the laboratory. CVC, derived from laser Doppler flux and mean arterial pressure, was examined in response to a standardized local heating protocol (0.5°C per 150 second from 33°C to 42°C, followed by 20 minutes at 44°C). Skin responses were examined at two locations on the forearm (between-site). Heating was repeated after a break of 24-72 hours (between-day). Reproducibility of skin responses at 33-42°C is presented for absolute CVC and relative CVC responses corrected for maximal CVC at 44°C (%CVCmax ). RESULTS: Between-day reproducibility of baseline CVC and %CVCmax for both sites was relatively poor (22-30%). At 42°C, CVC and %CVCmax responses showed less variation (9-19%), whilst absolute CVC responses at 44°C were 14-17%. Between-day variation for %CVCmax increased when using data from site 1 on day 1, but site 2 on the subsequent day (25%). CONCLUSION: Day-to-day reproducibility of baseline laser Doppler-derived skin perfusion responses is poor, but acceptable when absolute and relative skin perfusion to a local gradual heating protocol is utilized and site-to-site variation is minimized.
AU  - Dawson,EA
AU  - Low,DA
AU  - Meeuwis,IH
AU  - Kerstens,FG
AU  - Atkinson,CL
AU  - Cable,NT
AU  - Green,DJ
AU  - Thijssen,DH
DO  - 10.1111/micc.12196
EP  - 284
PY  - 2015///
SN  - 1549-8719
SP  - 276
TI  - Reproducibility of cutaneous vascular conductance responses to slow local heating assessed using seven-laser array probes
T2  - Microcirculation
UR  - http://dx.doi.org/10.1111/micc.12196
UR  - http://hdl.handle.net/10044/1/31213
VL  - 22
ER  -
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