Imperial College London
Dr David Low

DrDavidLow

Faculty of Medicine, Department of Surgery & Cancer

Honorary Senior Lecturer
 
 
 
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+44 (0)1519 046 244david.low

 
 
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Summary

 

Publications

Citation

BibTex format

@article{Stuebner:2015:10.1007/s10286-015-0270-5,
author = {Stuebner, E and Vichayanrat, E and Low, DA and Mathias, CJ and Isenmann, S and Haensch, CA},
doi = {10.1007/s10286-015-0270-5},
journal = {Clinical Autonomic Research},
pages = {109--116},
title = {Non-dipping nocturnal blood pressure and psychosis parameters in Parkinson disease},
url = {http://dx.doi.org/10.1007/s10286-015-0270-5},
volume = {25},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundNon-motor symptoms are increasingly recognized in Parkinson disease (PD) and include physical as well as psychological symptoms. A psychological condition that has been well studied in PD is psychosis. Cardiovascular autonomic dysfunction in PD can include a reversed or loss of blood pressure (BP) circadian rhythm, referred to as nocturnal non-dipping. The aim of this study was to determine the relationship between 24 h ambulatory blood pressure measurements (ABPM), i.e., absence or presence of nocturnal dipping, and psychosis scores in PD.MethodsTwenty-one patiens with PD underwent 24 h ABPM using an autonomic protocol. A decrease in nocturnal mean arterial blood pressure of less than 10 % was defined as non-dipping. Patients were interviewed (including the brief psychiatric rating scale; BPRS) for the assessment of psychosis.ResultsEleven patients were dippers and 10 were non-dippers. BPRS scores were higher in non-dippers, who, on average, met the criteria for psychosis (mean non-dipper BPRS: 34.3 ± 7.3 vs mean dipper BPRS: 27.5 ± 5.3; cutoff for “mildly ill” 31). There was a correlation between BPRS scores and non-dipping, indicating that those patients who had a blunted nocturnal fall in BP were more prone to psychotic symptoms (Pearson’s Correlation = 0.554, p = 0.009).ConclusionThese results suggest that, among PD patients, a non-dipping circadian rhythm is associated with more severe symptoms of psychosis than is a dipping circadian rhythm. This association warrants further investigation.
AU  - Stuebner,E
AU  - Vichayanrat,E
AU  - Low,DA
AU  - Mathias,CJ
AU  - Isenmann,S
AU  - Haensch,CA
DO  - 10.1007/s10286-015-0270-5
EP  - 116
PY  - 2015///
SN  - 1619-1560
SP  - 109
TI  - Non-dipping nocturnal blood pressure and psychosis parameters in Parkinson disease
T2  - Clinical Autonomic Research
UR  - http://dx.doi.org/10.1007/s10286-015-0270-5
UR  - http://hdl.handle.net/10044/1/31360
VL  - 25
ER  -
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