Imperial College London
Dr David Low

DrDavidLow

Faculty of Medicine, Department of Surgery & Cancer

Honorary Senior Lecturer
 
 
 
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+44 (0)1519 046 244david.low

 
 
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Summary

 

Publications

Citation

BibTex format

@article{Bailey:2016:10.1097/GME.0000000000000625,
author = {Bailey, TG and Cable, NT and Aziz, N and Dobson, R and Sprung, VS and Low, DA and Jones, H},
doi = {10.1097/GME.0000000000000625},
journal = {Menopause},
title = {Exercise training reduces the frequency of menopausal hot flushes by improving thermoregulatory control},
url = {http://dx.doi.org/10.1097/GME.0000000000000625},
volume = {23},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE: Postmenopausal hot flushes occur due to a reduction in estrogen production causing thermoregulatory and vascular dysfunction. Exercise training enhances thermoregulatory control of sweating, skin and brain blood flow. We aimed to determine if improving thermoregulatory control and vascular function with exercise training alleviated hot flushes. METHODS: Twenty-one symptomatic women completed a 7-day hot flush questionnaire and underwent brachial artery flow-mediated dilation and a cardiorespiratory fitness test. Sweat rate and skin blood flow temperature thresholds and sensitivities, and middle cerebral artery velocity (MCAv) were measured during passive heating. Women performed 16 weeks of supervised exercise training or control, and measurements were repeated. RESULTS: There was a greater improvement in cardiorespiratory fitness (4.45mL/kg/min [95% CI: 1.87, 8.16]; P=0.04) and reduced hot flush frequency (48 hot flushes/wk [39, 56]; P<0.001) after exercise compared with control. Exercise reduced basal core temperature (0.14°C [0.01, 0.27]; P=0.03) and increased basal MCAv (2.8cm/s [1.0, 5.2]; P=0.04) compared with control. Sweat rate and skin blood flow thresholds occurred approximately 0.19°C and 0.17°C earlier, alongside improved sweating sensitivity with exercise. MCAv decreased during heating (P<0.005), but was maintained 4.5cm/s (3.6, 5.5; P<0.005) higher during heating after exercise compared with control (0.6cm/s [-0.4, 1.4]). CONCLUSIONS: Exercise training that improves cardiorespiratory fitness reduces self-reported hot flushes. Improvements are likely mediated through greater thermoregulatory control in response to increases in core temperature and enhanced vascular function in the cutaneous and cerebral circulations.
AU  - Bailey,TG
AU  - Cable,NT
AU  - Aziz,N
AU  - Dobson,R
AU  - Sprung,VS
AU  - Low,DA
AU  - Jones,H
DO  - 10.1097/GME.0000000000000625
PY  - 2016///
SN  - 1072-3714
TI  - Exercise training reduces the frequency of menopausal hot flushes by improving thermoregulatory control
T2  - Menopause
UR  - http://dx.doi.org/10.1097/GME.0000000000000625
UR  - http://hdl.handle.net/10044/1/33199
VL  - 23
ER  -
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