Publications
114 results found
Wozniak MB, Scelo G, Muller DC, et al., 2015, Circulating MicroRNAs as Non-Invasive Biomarkers for Early Detection of Non-Small-Cell Lung Cancer, PLOS One, Vol: 10, ISSN: 1932-6203
BACKGROUND: Detection of lung cancer at an early stage by sensitive screening tests could be an important strategy to improving prognosis. Our objective was to identify a panel of circulating microRNAs in plasma that will contribute to early detection of lung cancer. MATERIAL AND METHODS: Plasma samples from 100 early stage (I to IIIA) non-small-cell lung cancer (NSCLC) patients and 100 non-cancer controls were screened for 754 circulating microRNAs via qRT-PCR, using TaqMan MicroRNA Arrays. Logistic regression with a lasso penalty was used to select a panel of microRNAs that discriminate between cases and controls. Internal validation of model discrimination was conducted by calculating the bootstrap optimism-corrected AUC for the selected model. RESULTS: We identified a panel of 24 microRNAs with optimum classification performance. The combination of these 24 microRNAs alone could discriminate lung cancer cases from non-cancer controls with an AUC of 0.92 (95% CI: 0.87-0.95). This classification improved to an AUC of 0.94 (95% CI: 0.90-0.97) following addition of sex, age and smoking status to the model. Internal validation of the model suggests that the discriminatory power of the panel will be high when applied to independent samples with a corrected AUC of 0.78 for the 24-miRNA panel alone. CONCLUSION: Our 24-microRNA predictor improves lung cancer prediction beyond that of known risk factors.
Ferrari P, Licaj I, Muller DC, et al., 2014, Lifetime alcohol use and overall and cause-specific mortality in the European Prospective Investigation into Cancer and nutrition (EPIC) study, BMJ Open, Vol: 4, ISSN: 2044-6055
Objectives: To investigate the role of factors thatmodulate the association between alcohol and mortality,and to provide estimates of absolute risk of death.Design: The European Prospective Investigation intoCancer and nutrition (EPIC).Setting: 23 centres in 10 countries.Participants: 380 395 men and women, free ofcancer, diabetes, heart attack or stroke at enrolment,followed up for 12.6 years on average.Main outcome measures: 20 453 fatal events, ofwhich 2053 alcohol-related cancers (ARC, includingcancers of upper aerodigestive tract, liver, colorectal andfemale breast), 4187 cardiovascular diseases/coronaryheart disease (CVD/CHD), 856 violent deaths andinjuries. Lifetime alcohol use was assessed atrecruitment.Results: HRs comparing extreme drinkers (≥30 g/dayin women and ≥60 g/day in men) to moderate drinkers(0.1–4.9 g/day) were 1.27 (95% CI 1.13 to 1.43) inwomen and 1.53 (1.39 to 1.68) in men. Strongassociations were observed for ARC mortality, in menparticularly, and for violent deaths and injuries, in menonly. No associations were observed for CVD/CHDmortality among drinkers, whereby HRs were higher innever compared to moderate drinkers. Overall mortalityseemed to be more strongly related to beer than wineuse, particularly in men. The 10-year risks of overalldeath for women aged 60 years, drinking more than30 g/day was 5% and 7%, for never and currentsmokers, respectively. Corresponding figures in menconsuming more than 60 g/day were 11% and 18%, innever and current smokers, respectively. In competingrisks analyses, mortality due to CVD/CHD was morepronounced than ARC in men, while CVD/CHD and ARCmortality were of similar magnitude in women.Conclusions: In this large European cohort, alcohol usewas positively associated with overall mortality, ARC andviolent death and injuries, but marginally to CVD/CHD.Absolute risks of death observed in EPIC suggest thatalcohol is an important determinant of total mortality.
Johansson M, Fanidi A, Muller DC, et al., 2014, Circulating Biomarkers of One-Carbon Metabolism in Relation to Renal Cell Carcinoma Incidence and Survival, JNCI: Journal of the National Cancer Institute, Vol: 106, ISSN: 0027-8874
Background The etiology of renal cell carcinoma (RCC) is only partially understood, but a metabolic component appears likely.We investigated biomarkers of one-carbon metabolism and RCC onset and survival.Methods The European Prospective Investigation into Cancer and Nutrition (EPIC) recruited 385747 participants with bloodsamples between 1992 and 2000, and this analysis included 556 RCC case-control pairs. A subsequent replicationstudy included 144 case-control pairs nested within the Melbourne Collaborative Cohort Study (MCCS). Plasmaconcentrations of vitamin B2, vitamin B6, folate, vitamin B12, methionine and homocysteine were measuredin prediagnostic samples and evaluated with respect to RCC risk using conditional and unconditional logisticregression models, and to all-cause mortality in RCC cases using Cox regression models. All statistical tests weretwo-sided.Results EPIC participants with higher plasma concentrations of vitamin B6 had lower risk of RCC, the odds ratio comparingthe 4th and 1st quartiles (OR4vs1) being 0.40 95% confidence interval [CI] = 0.28 to 0.57, Ptrend < .001. We foundsimilar results after adjusting for potential confounders (adjusted Ptrend < .001). In survival analysis, the hazardratio for all-cause mortality in RCC cases when comparing the 4th and 1st quartiles (HR4vs1) of vitamin B6 was 0.57(95% CI = 0.37 to 0.87, Ptrend < .001). Subsequent replication of these associations within the MCCS yielded very similar results for both RCC risk(OR4vs1 = 0.47, 95% CI = 0.23 to 0.99, Ptrend = .07) and all-cause mortality (HR4vs1 = 0.56, 95% CI = 0.27 to 1.17,Ptrend = .02). No association was evident for the other measured biomarkers.Conclusion Study participants with higher circulating concentrations of vitamin B6 had lower risk of RCC and improved survivalfollowing diagnosis in two independent cohorts.
Agogo GO, van der Voet H, van't Veer P, et al., 2014, Use of Two-Part Regression Calibration Model to Correct for Measurement Error in Episodically Consumed Foods in a Single-Replicate Study Design: EPIC Case Study, PLOS One, Vol: 9, ISSN: 1932-6203
In epidemiologic studies, measurement error in dietary variables often attenuates association between dietary intake and disease occurrence. To adjust for the attenuation caused by error in dietary intake, regression calibration is commonly used. To apply regression calibration, unbiased reference measurements are required. Short-term reference measurements for foods that are not consumed daily contain excess zeroes that pose challenges in the calibration model. We adapted two-part regression calibration model, initially developed for multiple replicates of reference measurements per individual to a single-replicate setting. We showed how to handle excess zero reference measurements by two-step modeling approach, how to explore heteroscedasticity in the consumed amount with variance-mean graph, how to explore nonlinearity with the generalized additive modeling (GAM) and the empirical logit approaches, and how to select covariates in the calibration model. The performance of two-part calibration model was compared with the one-part counterpart. We used vegetable intake and mortality data from European Prospective Investigation on Cancer and Nutrition (EPIC) study. In the EPIC, reference measurements were taken with 24-hour recalls. For each of the three vegetable subgroups assessed separately, correcting for error with an appropriately specified two-part calibration model resulted in about three fold increase in the strength of association with all-cause mortality, as measured by the log hazard ratio. Further found is that the standard way of including covariates in the calibration model can lead to over fitting the two-part calibration model. Moreover, the extent of adjusting for error is influenced by the number and forms of covariates in the calibration model. For episodically consumed foods, we advise researchers to pay special attention to response distribution, nonlinearity, and covariate inclusion in specifying the calibration model.
Engeset D, Braaten T, Teucher B, et al., 2014, Fish consumption and mortality in the European Prospective Investigation into Cancer and Nutrition cohort, European Journal of Epidemiology, Vol: 30, Pages: 57-70, ISSN: 1573-7284
Fish is a source of important nutrients and may play a role in preventing heart diseases and other health outcomes. However, studies of overall mortality and cause-specific mortality related to fish consumption are inconclusive. We examined the rate of overall mortality, as well as mortality from ischaemic heart disease and cancer in relation to the intake of total fish, lean fish, and fatty fish in a large prospective cohort including ten European countries. More than 500,000 men and women completed a dietary questionnaire in 1992–1999 and were followed up for mortality until the end of 2010. 32,587 persons were reported dead since enrolment. Hazard ratios and their 99 % confidence interval were estimated using Cox proportional hazard regression models. Fish consumption was examined using quintiles based on reported consumption, using moderate fish consumption (third quintile) as reference, and as continuous variables, using increments of 10 g/day. All analyses were adjusted for possible confounders. No association was seen for fish consumption and overall or cause-specific mortality for both the categorical and the continuous analyses, but there seemed to be a U-shaped trend (p < 0.000) with fatty fish consumption and total mortality and with total fish consumption and cancer mortality (p = 0.046).
Muller DC, Fanidi A, Midttun O, et al., 2014, Circulating 25-Hydroxyvitamin D<sub>3</sub> in Relation to Renal Cell Carcinoma Incidence and Survival in the EPIC Cohort, AMERICAN JOURNAL OF EPIDEMIOLOGY, Vol: 180, Pages: 810-820, ISSN: 0002-9262
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- Citations: 24
Papa N, Lawrentschuk N, Muller D, et al., 2014, Rural residency and prostate cancer specific mortality: results from the Victorian Radical Prostatectomy Register, AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH, Vol: 38, Pages: 449-454, ISSN: 1326-0200
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- Citations: 18
Hussain SM, Wang Y, Muller DC, et al., 2014, Association between index-to-ring finger length ratio and risk of severe knee and hip osteoarthritis requiring total joint replacement, RHEUMATOLOGY, Vol: 53, Pages: 1200-1207, ISSN: 1462-0324
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- Citations: 17
Severi G, FitzGerald LM, Muller DC, et al., 2014, A three-protein biomarker panel assessed in diagnostic tissue predicts death from prostate cancer for men with localized disease, Cancer Medicine, Vol: 3, Pages: 1266-1274, ISSN: 2045-7634
Only a minority of prostate cancers lead to death. Because no tissue biomarkers of aggressiveness other than Gleason score are available at diagnosis, many nonlethal cancers are treated aggressively. We evaluated whether a panel of biomarkers, associated with a range of disease outcomes in previous studies, could predict death from prostate cancer for men with localized disease. Using a case-only design, subjects were identified from three Australian epidemiological studies. Men who had died of their disease, "cases" (N = 83), were matched to "referents" (N = 232), those who had not died of prostate cancer, using incidence density sampling. Diagnostic tissue was retrieved to assess expression of AZGP1, MUC1, NKX3.1, p53, and PTEN by semiquantitative immunohistochemistry (IHC). Poisson regression was used to estimate mortality rate ratios (MRRs) adjusted for age, Gleason score, and stage and to estimate survival probabilities. Expression of MUC1 and p53 was associated with increased mortality (MRR 2.51, 95% CI 1.14-5.54, P = 0.02 and 3.08, 95% CI 1.41-6.95, P = 0.005, respectively), whereas AZGP1 expression was associated with decreased mortality (MRR 0.44, 95% CI 0.20-0.96, P = 0.04). Analyzing all markers under a combined model indicated that the three markers were independent predictors of prostate cancer death and survival. For men with localized disease at diagnosis, assessment of AZGP1, MUC1, and p53 expression in diagnostic tissue by IHC could potentially improve estimates of risk of dying from prostate cancer based only on Gleason score and clinical stage.
Bolton DM, Ta A, Bagnato M, et al., 2014, Interval to biochemical recurrence following radical prostatectomy does not affect survival in men with low-risk prostate cancer, WORLD JOURNAL OF UROLOGY, Vol: 32, Pages: 431-435, ISSN: 0724-4983
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- Citations: 15
Papa N, Lawrentschuk N, Muller D, et al., 2014, Rural residency and prostate cancer specific mortality: results from the Victorian Radical Prostatectomy Register, 67th Annual Scientific Meeting of the Urological-Society-of-Australia-and-New-Zealand, Publisher: WILEY-BLACKWELL, Pages: 40-40, ISSN: 1464-4096
Muller DC, 2013, Second to fourth digit ratio: A predictor of disease in later life?, MATURITAS, Vol: 75, Pages: 1-2, ISSN: 0378-5122
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- Citations: 4
Muller DC, Manning JT, Hopper JL, et al., 2013, No strong association between second to fourth digit ratio (2D:4D) and adult anthropometric measures with emphasis on adiposity, ANNALS OF HUMAN BIOLOGY, Vol: 40, Pages: 201-204, ISSN: 0301-4460
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- Citations: 13
Muller DC, Baglietto L, Manning JT, et al., 2013, Reply to comment on: 'Second to fourth digit ratio (2D:4D), breast cancer risk factors, and breast cancer risk: a prospective cohort study', BRITISH JOURNAL OF CANCER, Vol: 108, Pages: 743-743, ISSN: 0007-0920
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- Citations: 2
Muller DC, Giles GG, Sinclair R, et al., 2013, Age-Dependent Associations between Androgenetic Alopecia and Prostate Cancer Risk, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol: 22, Pages: 209-215, ISSN: 1055-9965
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- Citations: 17
Muller DC, Baglietto L, Manning JT, et al., 2012, Second to fourth digit ratio (2D: 4D), breast cancer risk factors, and breast cancer risk: a prospective cohort study, BRITISH JOURNAL OF CANCER, Vol: 107, Pages: 1631-1636, ISSN: 0007-0920
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- Citations: 64
Jabbour A, Boshell D, Sesel K, et al., 2012, Inducible myocardial ischaemia diagnosed using computed tomography dipyridamole stress myocardial perfusion technique, JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY, Vol: 56, Pages: 445-448, ISSN: 1754-9477
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- Citations: 4
Muller DC, Giles GG, Manning JT, et al., 2011, Second to fourth digit ratio (2D: 4D) and prostate cancer risk in the Melbourne Collaborative Cohort Study, BRITISH JOURNAL OF CANCER, Vol: 105, Pages: 438-440, ISSN: 0007-0920
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- Citations: 27
Muller DC, Giles GG, Bassett J, et al., 2011, Second to fourth digit ratio (2D:4D) and concentrations of circulating sex hormones in adulthood, Reproductive Biology and Endocrinology, Vol: 9, ISSN: 1477-7827
BACKGROUND: The second to fourth digit ratio (2D:4D) is used as a marker of prenatal sex hormone exposure. The objective of this study was to examine whether circulating concentrations of sex hormones and SHBG measured in adulthood was associated with 2D:4D. METHODS: This analysis was based on a random sample from the Melbourne Collaborative Cohort Study. The sample consisted of of 1036 men and 620 post-menopausal women aged between 39 and 70 at the time of blood draw. Concentrations of circulating sex hormones were measured from plasma collected at baseline (1990-1994), while digit length was measured from hand photocopies taken during a recent follow-up (2003-2009). The outcome measures were circulating concentrations of testosterone, oestradiol, dehydroepiandrosterone sulphate, androstenedione, Sex Hormone Binding Globulin, androstenediol glucoronide for men only and oestrone sulphate for women only. Free testosterone and oestradiol were estimated using standard formulae derived empirically. Predicted geometric mean hormone concentrations (for tertiles of 2D:4D) and conditional correlation coefficients (for continuous 2D:4D) were obtained using mixed effects linear regression models. RESULTS: No strong associations were observed between 2D:4D measures and circulating concentrations of hormones for men or women. For males, right 2D:4D was weakly inversely associated with circulating testosterone (predicted geometric mean testosterone was 15.9 and 15.0 nmol/L for the lowest and highest tertiles of male right 2D:4D respectively (P-trend = 0.04). There was a similar weak association between male right 2D:4D and the ratio of testosterone to oestradiol. These associations were not evident in analyses of continuous 2D:4D. CONCLUSIONS: There were no strong associations between any adult circulating concentration of sex hormone or SHGB and 2D:4D. These results contribute to the growing body of evidence indicating that 2D:4D is unrelated to adult sex hormone concentrations
Severi G, Baglietto L, Muller DC, et al., 2010, Asthma, Asthma Medications, and Prostate Cancer Risk, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol: 19, Pages: 2318-2324, ISSN: 1055-9965
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- Citations: 24
Muller DC, Severi G, Baglietto L, et al., 2009, Dietary Patterns and Prostate Cancer Risk, CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol: 18, Pages: 3126-3129, ISSN: 1055-9965
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- Citations: 40
Abben R, Abizaid A, Abou-Chebl A, et al., 2009, Angiography and Interventional Cardiology (i2 Summit) (vol 53, pg A1, 2009), JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 53, Pages: 1383-1386, ISSN: 0735-1097
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- Citations: 1
Kelsall HL, Baglietto L, Muller D, et al., 2009, The effect of socioeconomic status on survival from colorectal cancer in the Melbourne Collaborative Cohort Study, SOCIAL SCIENCE & MEDICINE, Vol: 68, Pages: 290-297, ISSN: 0277-9536
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- Citations: 36
Dehmer GJ, Blankenship J, Wharton TP, et al., 2007, The current status and future direction of percutaneous coronary intervention without on-site surgical backup: An expert consensus document from the society for cardiovascular angiography and interventions, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 69, Pages: 471-478, ISSN: 1522-1946
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- Citations: 46
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