Imperial College London
Portrait Picture

Dr David C Muller

Faculty of Medicine, School of Public Health

Senior Lecturer in Cancer Epidemiology and Biostatistics
 
 
 
//

Contact

 

+44 (0)20 7594 0856david.muller

 
 
//

Location

 

161Norfolk PlaceSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Honda:2019:10.1002/ijc.31900,
author = {Honda, K and Katzke, VA and Husing, A and Okaya, S and Shoji, H and Onidani, K and Olsen, A and Tjonneland, A and Overvad, K and Weiderpass, E and Vineis, P and Muller, DC and Tsilidis, KK and Palli, D and Pala, V and Tumino, R and Naccarati, A and Panico, S and Aleksandrova, K and Boeing, H and Bueno-de-Mesquita, HB and Peeters, PH and Trichopoulou, A and Lagiou, P and Khab, K-T and Wareham, NJ and Travis, RC and Merino, S and Duell, EJ and Rodríguez-Barranco, M and Chirlaque, MD and Barricarte, A and Rebours, V and Boutron-Ruault, M-C and Romana, Mancini F and Brennan, P and Scelo, G and Manjer, J and Sund, M and Ohlund, D and Canzian, F and Kaaks, R},
doi = {10.1002/ijc.31900},
journal = {International Journal of Cancer},
pages = {1877--1887},
title = {CA19-9 and Apolipoprotein-A2 isoforms as detection markers for pancreatic cancer - a prospective evaluation},
url = {http://dx.doi.org/10.1002/ijc.31900},
volume = {144},
year = {2019}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Recently, we identified unique processing patterns of apolipoprotein A2 (ApoA2) in patients with pancreatic cancer. This study provides a first prospective evaluation of an ApoA2 isoform (“ApoA2-ATQ/AT”), alone and in combination with carbohydrate antigen 19-9 (CA19-9), as an early detection biomarker for pancreatic cancer.We performed ELISA measurements of CA19-9 and ApoA2-ATQ/AT in 156 patients with pancreatic cancer and 217 matched controls within the European EPIC cohort, using plasma samples collected up to 60 months prior to diagnosis. The detection discrimination statistics were calculated for risk scores by strata of lag-time.For CA19-9, in univariate marker analyses, C-statistics to distinguish future pancreatic cancer patients from cancer-free individuals were 0.80 for plasma taken ≤6 months before diagnosis, and 0.71 for >6-18 months; for ApoA2-ATQ/AT, C-statistics were 0.62, and 0.65, respectively. Joint models based on ApoA2-ATQ/AT plus CA19-9 significantly improved discrimination within >6-18 months (C = 0.74 vs. 0.71 for CA19-9 alone, p = 0.022) and ≤18 months (C = 0.75 vs. 0.74, p = 0.022). At 98% specificity, and for lag times of ≤6, >6-18 or ≤18 months, sensitivities were 57%, 36% and 43% for CA19-9 combined with ApoA2-ATQ/AT, respectively, vs. 50%, 29% and 36% for CA19-9 alone. Compared to CA19-9 alone, the combination of CA19-9 and ApoA2-ATQ/AT may improve detection of pancreatic cancer up to 18 months prior to diagnosis under usual care, and may provide a useful first measure for pancreatic cancer detection prior to imaging.
AU  - Honda,K
AU  - Katzke,VA
AU  - Husing,A
AU  - Okaya,S
AU  - Shoji,H
AU  - Onidani,K
AU  - Olsen,A
AU  - Tjonneland,A
AU  - Overvad,K
AU  - Weiderpass,E
AU  - Vineis,P
AU  - Muller,DC
AU  - Tsilidis,KK
AU  - Palli,D
AU  - Pala,V
AU  - Tumino,R
AU  - Naccarati,A
AU  - Panico,S
AU  - Aleksandrova,K
AU  - Boeing,H
AU  - Bueno-de-Mesquita,HB
AU  - Peeters,PH
AU  - Trichopoulou,A
AU  - Lagiou,P
AU  - Khab,K-T
AU  - Wareham,NJ
AU  - Travis,RC
AU  - Merino,S
AU  - Duell,EJ
AU  - Rodríguez-Barranco,M
AU  - Chirlaque,MD
AU  - Barricarte,A
AU  - Rebours,V
AU  - Boutron-Ruault,M-C
AU  - Romana,Mancini F
AU  - Brennan,P
AU  - Scelo,G
AU  - Manjer,J
AU  - Sund,M
AU  - Ohlund,D
AU  - Canzian,F
AU  - Kaaks,R
DO  - 10.1002/ijc.31900
EP  - 1887
PY  - 2019///
SN  - 0020-7136
SP  - 1877
TI  - CA19-9 and Apolipoprotein-A2 isoforms as detection markers for pancreatic cancer - a prospective evaluation
T2  - International Journal of Cancer
UR  - http://dx.doi.org/10.1002/ijc.31900
UR  - http://hdl.handle.net/10044/1/62704
VL  - 144
ER  -
Download