Imperial College London
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Dr David C Muller

Faculty of Medicine, School of Public Health

Senior Lecturer in Cancer Epidemiology and Biostatistics
 
 
 
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Contact

 

david.muller

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sandanger:2018:10.1038/s41598-018-34334-6,
author = {Sandanger, T and Nost, T and Guida, F and Rylander, C and Campanella, G and Muller, D and van, Dongen J and Boomsma, D and Johansson, M and Vineis, P and Vermeulen, R and Lund, E and Chadeau, M},
doi = {10.1038/s41598-018-34334-6},
journal = {Scientific Reports},
title = {DNA methylation and associated gene expression in blood prior to lung cancer diagnosis in the Norwegian Women and Cancer cohort},
url = {http://dx.doi.org/10.1038/s41598-018-34334-6},
volume = {8},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The majority of lung cancer is caused by tobacco smoking, and lung cancer-relevant epigenetic markers have been identified in relation to smoking exposure. Still, smoking-related markers appear to mediate little of the effect of smoking on lung cancer. Thus in order to identify disease-relevant markers and enhance our understanding of pathways, a wide search is warranted. Through an epigenome-wide search within a case-control study (131 cases, 129 controls) nested in a Norwegian prospective cohort of women, we found 25 CpG sites associated with lung cancer. Twenty-three were classified as associated with smoking (LC-AwS), and two were classified as unassociated with smoking (LC-non-AwS), as they remained associated with lung cancer after stringent adjustment for smoking exposure using the comprehensive smoking index (CSI): cg10151248 (PC, CSI-adjusted odds ratio (OR) = 0.34 [0.23–0.52] per standard deviation change in methylation) and cg13482620 (B3GNTL1, CSI-adjusted OR = 0.33 [0.22–0.50]). Analysis among never smokers and a cohort of smoking-discordant twins confirmed the classification of the two LC-non-AwS CpG sites. Gene expression profiles demonstrated that the LC-AwS CpG sites had different enriched pathways than LC-non-AwS sites. In conclusion, using blood-derived DNA methylation and gene expression profiles from a prospective lung cancer case-control study in women, we identified 25 CpG lung cancer markers prior to diagnosis, two of which were LC-non-AwS markers and related to distinct pathways.
AU  - Sandanger,T
AU  - Nost,T
AU  - Guida,F
AU  - Rylander,C
AU  - Campanella,G
AU  - Muller,D
AU  - van,Dongen J
AU  - Boomsma,D
AU  - Johansson,M
AU  - Vineis,P
AU  - Vermeulen,R
AU  - Lund,E
AU  - Chadeau,M
DO  - 10.1038/s41598-018-34334-6
PY  - 2018///
SN  - 2045-2322
TI  - DNA methylation and associated gene expression in blood prior to lung cancer diagnosis in the Norwegian Women and Cancer cohort
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-018-34334-6
UR  - http://hdl.handle.net/10044/1/65308
VL  - 8
ER  -
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