Imperial College London
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Dr David C Muller

Faculty of Medicine, School of Public Health

Senior Lecturer in Cancer Epidemiology and Biostatistics
 
 
 
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Contact

 

david.muller

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Muller:2019:10.1136/bmj.k4981,
author = {Muller, DC and Larose, TL and Hodge, A and Guida, F and Langhammer, A and Grankvist, K and Meyer, K and Cai, Q and Arslan, AA and Zeleniuch-Jacquotte, A and Albanes, D and Giles, GG and Sesso, HD and Lee, I-M and Gaziano, JM and Yuan, J-M and Hoffman, Bolton J and Buring, JE and Visvanathan, K and Le, Marchand L and Purdue, MP and Caporaso, NE and Midttun, Ø and Ueland, PM and Prentice, RL and Weinstein, SJ and Stevens, VL and Zheng, W and Blot, WJ and Shu, X-O and Zhang, X and Xiang, Y-B and Koh, W-P and Hveem, K and Thomson, CA and Pettinger, M and Engström, G and Brunnström, H and Milne, RL and Stampfer, MJ and Han, J and Johansson, M and Brennan, P and Severi, G and Johansson, M},
doi = {10.1136/bmj.k4981},
journal = {BMJ},
pages = {k4981--k4981},
title = {Circulating high sensitivity C reactive protein concentrations and risk of lung cancer: nested case-control study within Lung Cancer Cohort Consortium.},
url = {http://dx.doi.org/10.1136/bmj.k4981},
volume = {364},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVES: To conduct a comprehensive analysis of prospectively measured circulating high sensitivity C reactive protein (hsCRP) concentration and risk of lung cancer overall, by smoking status (never, former, and current smokers), and histological sub-type. DESIGN: Nested case-control study. SETTING: 20 population based cohort studies in Asia, Europe, Australia, and the United States. PARTICIPANTS: 5299 patients with incident lung cancer, with individually incidence density matched controls. EXPOSURE: Circulating hsCRP concentrations in prediagnostic serum or plasma samples. MAIN OUTCOME MEASURE: Incident lung cancer diagnosis. RESULTS: A positive association between circulating hsCRP concentration and the risk of lung cancer for current (odds ratio associated with a doubling in hsCRP concentration 1.09, 95% confidence interval 1.05 to 1.13) and former smokers (1.09, 1.04 to 1.14) was observed, but not for never smokers (P<0.01 for interaction). This association was strong and consistent across all histological subtypes, except for adenocarcinoma, which was not strongly associated with hsCRP concentration regardless of smoking status (odds ratio for adenocarcinoma overall 0.97, 95% confidence interval 0.94 to 1.01). The association between circulating hsCRP concentration and the risk of lung cancer was strongest in the first two years of follow-up for former and current smokers. Including hsCRP concentration in a risk model, in addition to smoking based variables, did not improve risk discrimination overall, but slightly improved discrimination for cancers diagnosed in the first two years of follow-up. CONCLUSIONS: Former and current smokers with higher circulating hsCRP concentrations had a higher risk of lung cancer overall. Circulating hsCRP concentration was not associated with the risk of lung adenocarcinoma. Circulating hsCRP concentration could be a prediagnostic marker of lung cancer rather than a causal risk factor.
AU  - Muller,DC
AU  - Larose,TL
AU  - Hodge,A
AU  - Guida,F
AU  - Langhammer,A
AU  - Grankvist,K
AU  - Meyer,K
AU  - Cai,Q
AU  - Arslan,AA
AU  - Zeleniuch-Jacquotte,A
AU  - Albanes,D
AU  - Giles,GG
AU  - Sesso,HD
AU  - Lee,I-M
AU  - Gaziano,JM
AU  - Yuan,J-M
AU  - Hoffman,Bolton J
AU  - Buring,JE
AU  - Visvanathan,K
AU  - Le,Marchand L
AU  - Purdue,MP
AU  - Caporaso,NE
AU  - Midttun,Ø
AU  - Ueland,PM
AU  - Prentice,RL
AU  - Weinstein,SJ
AU  - Stevens,VL
AU  - Zheng,W
AU  - Blot,WJ
AU  - Shu,X-O
AU  - Zhang,X
AU  - Xiang,Y-B
AU  - Koh,W-P
AU  - Hveem,K
AU  - Thomson,CA
AU  - Pettinger,M
AU  - Engström,G
AU  - Brunnström,H
AU  - Milne,RL
AU  - Stampfer,MJ
AU  - Han,J
AU  - Johansson,M
AU  - Brennan,P
AU  - Severi,G
AU  - Johansson,M
DO  - 10.1136/bmj.k4981
EP  - 4981
PY  - 2019///
SN  - 0959-8138
SP  - 4981
TI  - Circulating high sensitivity C reactive protein concentrations and risk of lung cancer: nested case-control study within Lung Cancer Cohort Consortium.
T2  - BMJ
UR  - http://dx.doi.org/10.1136/bmj.k4981
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30606716
UR  - http://hdl.handle.net/10044/1/66177
VL  - 364
ER  -
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