Imperial College London
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Dr David C Muller

Faculty of Medicine, School of Public Health

Senior Lecturer in Cancer Epidemiology and Biostatistics
 
 
 
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david.muller

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Freisling:2020:10.1186/s12916-019-1474-7,
author = {Freisling, H and Viallon, V and Lennon, H and Bagnardi, V and Ricci, C and Butterworth, AS and Sweeting, M and Muller, D and Romieu, I and Bazelle, P and Kvaskoff, M and Arveux, P and Severi, G and Bamia, C and Kühn, T and Kaaks, R and Bergmann, M and Boeing, H and Tjønneland, A and Olsen, A and Overvad, K and Dahm, CC and Menéndez, V and Agudo, A and Sánchez, M-J and Amiano, P and Santiuste, C and Gurrea, AB and Tong, TYN and Schmidt, JA and Tzoulaki, I and Tsilidis, KK and Ward, H and Palli, D and Agnoli, C and Tumino, R and Ricceri, F and Panico, S and Picavet, HSJ and Bakker, M and Monninkhof, E and Nilsson, P and Manjer, J and Rolandsson, O and Thysell, E and Weiderpass, E and Jenab, M and Riboli, E and Vineis, P and Danesh, J and Wareham, NJ and Gunter, MJ and Ferrari, P},
doi = {10.1186/s12916-019-1474-7},
journal = {BMC Medicine},
pages = {5--5},
title = {Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study},
url = {http://dx.doi.org/10.1186/s12916-019-1474-7},
volume = {18},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Although lifestyle factors have been studied in relation to individual non-communicable diseases (NCDs), their association with development of a subsequent NCD, defined as multimorbidity, has been scarcely investigated. The aim of this study was to investigate associations between five lifestyle factors and incident multimorbidity of cancer and cardiometabolic diseases. METHODS: In this prospective cohort study, 291,778 participants (64% women) from seven European countries, mostly aged 43 to 58 years and free of cancer, cardiovascular disease (CVD), and type 2 diabetes (T2D) at recruitment, were included. Incident multimorbidity of cancer and cardiometabolic diseases was defined as developing subsequently two diseases including first cancer at any site, CVD, and T2D in an individual. Multi-state modelling based on Cox regression was used to compute hazard ratios (HR) and 95% confidence intervals (95% CI) of developing cancer, CVD, or T2D, and subsequent transitions to multimorbidity, in relation to body mass index (BMI), smoking status, alcohol intake, physical activity, adherence to the Mediterranean diet, and their combination as a healthy lifestyle index (HLI) score. Cumulative incidence functions (CIFs) were estimated to compute 10-year absolute risks for transitions from healthy to cancer at any site, CVD (both fatal and non-fatal), or T2D, and to subsequent multimorbidity after each of the three NCDs. RESULTS: During a median follow-up of 11 years, 1910 men and 1334 women developed multimorbidity of cancer and cardiometabolic diseases. A higher HLI, reflecting healthy lifestyles, was strongly inversely associated with multimorbidity, with hazard ratios per 3-unit increment of 0.75 (95% CI, 0.71 to 0.81), 0.84 (0.79 to 0.90), and 0.82 (0.77 to 0.88) after cancer, CVD, and T2D, respectively. After T2D, the 10-year absolute risks of multimorbidity were 40% and 25% for men and women, respectively, with unhealthy lifestyle, and 30% and 18
AU  - Freisling,H
AU  - Viallon,V
AU  - Lennon,H
AU  - Bagnardi,V
AU  - Ricci,C
AU  - Butterworth,AS
AU  - Sweeting,M
AU  - Muller,D
AU  - Romieu,I
AU  - Bazelle,P
AU  - Kvaskoff,M
AU  - Arveux,P
AU  - Severi,G
AU  - Bamia,C
AU  - Kühn,T
AU  - Kaaks,R
AU  - Bergmann,M
AU  - Boeing,H
AU  - Tjønneland,A
AU  - Olsen,A
AU  - Overvad,K
AU  - Dahm,CC
AU  - Menéndez,V
AU  - Agudo,A
AU  - Sánchez,M-J
AU  - Amiano,P
AU  - Santiuste,C
AU  - Gurrea,AB
AU  - Tong,TYN
AU  - Schmidt,JA
AU  - Tzoulaki,I
AU  - Tsilidis,KK
AU  - Ward,H
AU  - Palli,D
AU  - Agnoli,C
AU  - Tumino,R
AU  - Ricceri,F
AU  - Panico,S
AU  - Picavet,HSJ
AU  - Bakker,M
AU  - Monninkhof,E
AU  - Nilsson,P
AU  - Manjer,J
AU  - Rolandsson,O
AU  - Thysell,E
AU  - Weiderpass,E
AU  - Jenab,M
AU  - Riboli,E
AU  - Vineis,P
AU  - Danesh,J
AU  - Wareham,NJ
AU  - Gunter,MJ
AU  - Ferrari,P
DO  - 10.1186/s12916-019-1474-7
EP  - 5
PY  - 2020///
SN  - 1741-7015
SP  - 5
TI  - Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study
T2  - BMC Medicine
UR  - http://dx.doi.org/10.1186/s12916-019-1474-7
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31918762
UR  - http://hdl.handle.net/10044/1/76262
VL  - 18
ER  -
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