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@article{Van:2021:10.3390/nu13061843,
author = {Van, Puyvelde H and Papadimitriou, N and Clasen, J and Muller, D and Biessy, C and Ferrari, P and Halkjaer, J and Overvad, K and Tjonneland, A and Fortner, RT and Katzke, V and Schulze, MB and Chiodini, P and Masala, G and Pala, V and Sacerdote, C and Tumino, R and Bakker, MF and Agudo, A and Ardanaz, E and Chirlaque, Lopez MD and Sanchez, M-J and Ericson, U and Gylling, B and Karlsson, T and Manjer, J and Schmidt, JA and Nicolas, G and Casagrande, C and Weiderpass, E and Heath, AK and Godderis, L and Van, Herck K and De, Bacquer D and Gunter, MJ and Huybrechts, I},
doi = {10.3390/nu13061843},
journal = {Nutrients},
pages = {1--15},
title = {Dietary methyl-group donor intake and breast cancer risk in the European prospective investigation into cancer and nutrition (EPIC)},
url = {http://dx.doi.org/10.3390/nu13061843},
volume = {13},
year = {2021}
}

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TY  - JOUR
AB  - (1) Background: Methyl-group donors (MGDs), including folate, choline, betaine, and methionine, may influence breast cancer (BC) risk through their role in one-carbon metabolism; (2) Methods: We studied the relationship between dietary intakes of MGDs and BC risk, adopting data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort; (3) Results: 318,686 pre- and postmenopausal women were followed between enrolment in 1992–2000 and December 2013–December 2015. Dietary MGD intakes were estimated at baseline through food-frequency questionnaires. Multivariable Cox proportional hazards regression models were used to quantify the association between dietary intake of MGDs, measured both as a calculated score based on their sum and individually, and BC risk. Subgroup analyses were performed by hormone receptor status, menopausal status, and level of alcohol intake. During a mean follow-up time of 14.1 years, 13,320 women with malignant BC were identified. No associations were found between dietary intakes of the MGD score or individual MGDs and BC risk. However, a potential U-shaped relationship was observed between dietary folate intake and overall BC risk, suggesting an inverse association for intakes up to 350 µg/day compared to a reference intake of 205 µg/day. No statistically significant differences in the associations were observed by hormone receptor status, menopausal status, or level of alcohol intake; (4) Conclusions: There was no strong evidence for an association between MGDs involved in one-carbon metabolism and BC risk. However, a potential U-shaped trend was suggested for dietary folate intake and BC risk. Further research is needed to clarify this association.
AU  - Van,Puyvelde H
AU  - Papadimitriou,N
AU  - Clasen,J
AU  - Muller,D
AU  - Biessy,C
AU  - Ferrari,P
AU  - Halkjaer,J
AU  - Overvad,K
AU  - Tjonneland,A
AU  - Fortner,RT
AU  - Katzke,V
AU  - Schulze,MB
AU  - Chiodini,P
AU  - Masala,G
AU  - Pala,V
AU  - Sacerdote,C
AU  - Tumino,R
AU  - Bakker,MF
AU  - Agudo,A
AU  - Ardanaz,E
AU  - Chirlaque,Lopez MD
AU  - Sanchez,M-J
AU  - Ericson,U
AU  - Gylling,B
AU  - Karlsson,T
AU  - Manjer,J
AU  - Schmidt,JA
AU  - Nicolas,G
AU  - Casagrande,C
AU  - Weiderpass,E
AU  - Heath,AK
AU  - Godderis,L
AU  - Van,Herck K
AU  - De,Bacquer D
AU  - Gunter,MJ
AU  - Huybrechts,I
DO  - 10.3390/nu13061843
EP  - 15
PY  - 2021///
SN  - 2072-6643
SP  - 1
TI  - Dietary methyl-group donor intake and breast cancer risk in the European prospective investigation into cancer and nutrition (EPIC)
T2  - Nutrients
UR  - http://dx.doi.org/10.3390/nu13061843
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000666446000001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.mdpi.com/2072-6643/13/6/1843
UR  - http://hdl.handle.net/10044/1/92268
VL  - 13
ER  -

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