Imperial College London
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Dr David C Muller

Faculty of Medicine, School of Public Health

Senior Lecturer in Cancer Epidemiology and Biostatistics
 
 
 
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Contact

 

+44 (0)20 7594 0856david.muller

 
 
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Location

 

161Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mariosa:2022:jnci/djac061,
author = {Mariosa, D and Smith-Byrne, K and Richardson, TG and Ferrari, P and Gunter, MJ and Papadimitriou, N and Murphy, N and Christakoudi, S and Tsilidis, KK and Riboli, E and Muller, D and Purdue, MP and Chanock, SJ and Hung, RJ and Amos, CI and O'Mara, TA and Amiano, P and Pasanisi, F and Rodriguez-Barranco, M and Krogh, V and Tjønneland, A and Halkjær, J and Perez-Cornago, A and Chirlaque, M-D and Skeie, G and Rylander, C and Borch, KB and Aune, D and Heath, AK and Ward, HA and Schulze, M and Bonet, C and Weiderpass, E and Smith, GD and Brennan, P and Johansson, M},
doi = {jnci/djac061},
journal = {JNCI: Journal of the National Cancer Institute},
pages = {1296--1300},
title = {Body size at different ages and risk of six cancers: a Mendelian randomization and prospective cohort study},
url = {http://dx.doi.org/10.1093/jnci/djac061},
volume = {114},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for six obesity-related cancers, we performed univariable and multivariable analyses using i) Mendelian randomization (MR) analysis and ii) longitudinal analyses in prospective cohorts. Both the MR and longitudinal analyses indicated that larger body size at age 10 was associated with higher risk of endometrial (ORMR=1.61, 95%CI = 1.23–2.11) and kidney cancer (ORMR=1.40, 95%CI = 1.09–1.80). These associations were attenuated after accounting for adult body size in both the MR and cohort analyses. Early life BMI was not consistently associated with the other investigated cancers. The lack of clear independent risk associations suggests that early life BMI influences endometrial and kidney cancer risk mainly through pathways that are common with adult BMI.
AU  - Mariosa,D
AU  - Smith-Byrne,K
AU  - Richardson,TG
AU  - Ferrari,P
AU  - Gunter,MJ
AU  - Papadimitriou,N
AU  - Murphy,N
AU  - Christakoudi,S
AU  - Tsilidis,KK
AU  - Riboli,E
AU  - Muller,D
AU  - Purdue,MP
AU  - Chanock,SJ
AU  - Hung,RJ
AU  - Amos,CI
AU  - O'Mara,TA
AU  - Amiano,P
AU  - Pasanisi,F
AU  - Rodriguez-Barranco,M
AU  - Krogh,V
AU  - Tjønneland,A
AU  - Halkjær,J
AU  - Perez-Cornago,A
AU  - Chirlaque,M-D
AU  - Skeie,G
AU  - Rylander,C
AU  - Borch,KB
AU  - Aune,D
AU  - Heath,AK
AU  - Ward,HA
AU  - Schulze,M
AU  - Bonet,C
AU  - Weiderpass,E
AU  - Smith,GD
AU  - Brennan,P
AU  - Johansson,M
DO  - jnci/djac061
EP  - 1300
PY  - 2022///
SN  - 0027-8874
SP  - 1296
TI  - Body size at different ages and risk of six cancers: a Mendelian randomization and prospective cohort study
T2  - JNCI: Journal of the National Cancer Institute
UR  - http://dx.doi.org/10.1093/jnci/djac061
UR  - https://academic.oup.com/jnci/advance-article/doi/10.1093/jnci/djac061/6570593
UR  - http://hdl.handle.net/10044/1/96670
VL  - 114
ER  -
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