Professor David Sharp is a neurologist and Centre Director of UK DRI Care Research & Technology, focusing on using technology to enhance the lives of people living with dementia. He is also Scientific Director of the Imperial College Clinical Imaging Facility and Associate Director of the Imperial Centre for Injury Studies. His research programme aims to improve clinical outcomes after dementia and traumatic brain injury (TBI), focusing on common cognitive impairments in domains such as memory and attention. He uses cognitive neuroscience and advanced neuroimaging to investigate the effect of brain injury on brain network function and the effects of inflammation and neurodegeneration. His has explored how new treatments of cognitive impairment can be personalised and his current work focuses on harnessing neurotechnology development to improve the lives of those living with dementia and the effects of brain injury.
et al., 2023, Alzheimer’s disease marker phospho-tau181 is not elevated in the first year after moderate-severe TBI, Journal of Neurology, Neurosurgery and Psychiatry, ISSN:0022-3050
Sharp DJ, Graham NSN, 2023, Clinical outcomes evolve years after traumatic brain injury, Nature Reviews Neurology, Vol:19, ISSN:1759-4758, Pages:579-580
et al., 2023, Multicohort cross-sectional study of cognitive and behavioural digital biomarkers in neurodegeneration: the Living Lab study protocol, Bmj Open, Vol:13, ISSN:2044-6055, Pages:1-9
et al., 2023, Distinct patterns of neurodegeneration after TBI and in Alzheimer's disease, Alzheimer's and Dementia, Vol:19, ISSN:1552-5260, Pages:3065-3077