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@article{De:2019:10.1097/QAD.0000000000002063,
author = {De, Francesco D and Wit, FW and Burkle, A and Oehlke, S and Kootstra, NA and Winston, A and Franceschi, C and Garagnani, P and Pirazzini, C and Libert, C and Grune, T and Weber, D and Jansen, EHJM and Sabin, CA and Reiss, P and Reiss, P and Winston, A and Wit, FW and Prins, M and van, der Loeff MFS and Schouten, J and Schmand, B and Geurtsen, GJ and Sharp, DJ and Caan, MWA and Majoie, C and Villaudy, J and Berkhout, B and Kootstra, NA and Gisslen, M and Pasternak, A and Sabin, CA and Guaraldi, G and Burkle, A and Libert, C and Franceschi, C and Kalsbeek, A and Fliers, E and Hoeijmakers, J and Pothof, J and van, der Valk M and Bisschop, PH and Portegies, P and Zaheri, S and Burger, D and Cole, JH and Biirkle, A and Zikkenheiner, W and Janssen, FR and Underwood, J and Kooij, KW and van, Zoest RA and Doyle, N and van, der Loeff MS and Schmand, BA and Verheij, E and Verboeket, SO and Elsenga, BC and Hillebregt, MMJ and Ruijs, YMC and Benschop, DP and Tembo, L and McDonald, L and Stott, M a},
doi = {10.1097/QAD.0000000000002063},
journal = {AIDS},
pages = {259--268},
title = {Do people living with HIV experience greater age advancement than their HIV-negative counterparts?},
url = {http://dx.doi.org/10.1097/QAD.0000000000002063},
volume = {33},
year = {2019}
}

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TY  - JOUR
AB  - Objectives: Despite successful antiretroviral therapy, people living with HIV (PLWH)may show signs of premature/accentuated aging. We compared established biomarkersof aging in PLWH, appropriately chosen HIV-negative individuals, and blood donors,and explored factors associated with biological age advancement.Design: Cross-sectional analysis of 134 PLWH on suppressive antiretroviral therapy, 79lifestyle-comparable HIV-negative controls aged 45 years or older from the Co-morBidity in Relation to AIDS (COBRA) cohort, and 35 age-matched blood donors.Methods: Biological age was estimated using a validated algorithm based on 10biomarkers. Associations between ‘age advancement’ (biological minus chronological age) and HIV status/parameters, lifestyle, cytomegalovirus (CMV), hepatitisB (HBV) and hepatitis C virus (HCV) infections were investigated using linear regression.Results: The average (95% CI) age advancement was greater in both HIV-positive [13.2(11.6–14.9) years] and HIV-negative [5.5 (3.8–7.2) years] COBRA participants comparedwith blood donors [7.0 (4.1 to 9.9) years, both P’s< 0.001)], but also in HIV-positivecompared with HIV-negative participants (P < 0.001). Chronic HBV, higher anti-CMVIgG titer and CD8þ T-cell count were each associated with increased age advancement, independently of HIV-status/group. Among HIV-positive participants, ageadvancement was increased by 3.5 (0.1–6.8) years among those with nadir CD4þT-cell count less than 200 cells/ml and by 0.1 (0.06–0.2) years for each additionalmonth of exposure to saquinavir.
AU  - De,Francesco D
AU  - Wit,FW
AU  - Burkle,A
AU  - Oehlke,S
AU  - Kootstra,NA
AU  - Winston,A
AU  - Franceschi,C
AU  - Garagnani,P
AU  - Pirazzini,C
AU  - Libert,C
AU  - Grune,T
AU  - Weber,D
AU  - Jansen,EHJM
AU  - Sabin,CA
AU  - Reiss,P
AU  - Reiss,P
AU  - Winston,A
AU  - Wit,FW
AU  - Prins,M
AU  - van,der Loeff MFS
AU  - Schouten,J
AU  - Schmand,B
AU  - Geurtsen,GJ
AU  - Sharp,DJ
AU  - Caan,MWA
AU  - Majoie,C
AU  - Villaudy,J
AU  - Berkhout,B
AU  - Kootstra,NA
AU  - Gisslen,M
AU  - Pasternak,A
AU  - Sabin,CA
AU  - Guaraldi,G
AU  - Burkle,A
AU  - Libert,C
AU  - Franceschi,C
AU  - Kalsbeek,A
AU  - Fliers,E
AU  - Hoeijmakers,J
AU  - Pothof,J
AU  - van,der Valk M
AU  - Bisschop,PH
AU  - Portegies,P
AU  - Zaheri,S
AU  - Burger,D
AU  - Cole,JH
AU  - Biirkle,A
AU  - Zikkenheiner,W
AU  - Janssen,FR
AU  - Underwood,J
AU  - Kooij,KW
AU  - van,Zoest RA
AU  - Doyle,N
AU  - van,der Loeff MS
AU  - Schmand,BA
AU  - Verheij,E
AU  - Verboeket,SO
AU  - Elsenga,BC
AU  - Hillebregt,MMJ
AU  - Ruijs,YMC
AU  - Benschop,DP
AU  - Tembo,L
AU  - McDonald,L
AU  - Stott,M
AU  - Legg,K
AU  - Lovell,A
AU  - Erlwein,O
AU  - Kingsley,C
AU  - Norsworthy,P
AU  - Mullaney,S
AU  - Kruijer,T
AU  - del,Grande L
AU  - Olthof,V
AU  - Visser,GR
AU  - May,L
AU  - Verbraak,F
AU  - Demirkaya,N
AU  - Visser,I
AU  - Majoie,CBLM
AU  - Su,T
AU  - Leech,R
AU  - Huguet,J
AU  - Frankin,E
AU  - van,der Kuyl A
AU  - Weijer,K
AU  - Siteur-Van,Rijnstra E
AU  - Harskamp-Holwerda,AM
AU  - Maurer,I
AU  - Ruiz,MMM
AU  - Girigorie,AF
AU  - Boeser-Nunnink,B
AU  - Kals-Beek,A
AU  - Bisschop,PHLT
AU  - de,Graaff-Teulen M
AU  - Dewaele,S
AU  - Garagnani,P
AU  - Pirazzini,C
AU  - Capri,M
AU  - Dall'Olio,F
AU  - Chiricolo,M
AU  - Salvioli,S
AU  - Fuchs,D
AU  - Zetterberg,H
AU  - Weber,D
AU  - Grune,T
AU  - Jansen,EHJM
AU  - De,Francesco D
AU  - Sindlinger,T
AU  - Oehlke,S
DO  - 10.1097/QAD.0000000000002063
EP  - 268
PY  - 2019///
SN  - 0269-9370
SP  - 259
TI  - Do people living with HIV experience greater age advancement than their HIV-negative counterparts?
T2  - AIDS
UR  - http://dx.doi.org/10.1097/QAD.0000000000002063
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000460936700009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/68177
VL  - 33
ER  -

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