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@article{Evans:2021:10.3389/fnins.2021.727311,
author = {Evans, M and Wade, C and Hohenschurz-Schmidt, D and Lally, P and Ugwudike, A and Shah, K and Bangerter, N and Sharp, D and Rice, ASC},
doi = {10.3389/fnins.2021.727311},
journal = {Frontiers in Neuroscience},
title = {Magnetic resonance imaging as a biomarker in diabetic and HIV-associated peripheral neuropathy: A systematic review-based narrative},
url = {http://dx.doi.org/10.3389/fnins.2021.727311},
volume = {15},
year = {2021}
}

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TY  - JOUR
AB  - Background: Peripheral neuropathy can be caused by diabetes mellitus and HIV infection, and often leaves patients with treatment-resistant neuropathic pain. To better treat this condition, we need greater understanding of the pathogenesis, as well as objective biomarkers to predict treatment response. Magnetic resonance imaging (MRI) has a firm place as a biomarker for diseases of the central nervous system (CNS), but until recently has had little role for disease of the peripheral nervous system. Objectives: To review the current state-of-the-art of peripheral nerve MRI in diabetic and HIV symmetrical polyneuropathy. We used systematic literature search methods to identify all studies currently published, using this as a basis for a narrative review to discuss major findings in the literature. We also assessed risk of bias, as well as technical aspects of MRI and statistical analysis. Methods: Protocol was pre-registered on NIHR PROSPERO database. MEDLINE, Web of Science and EMBASE databases were searched from 1946 to 15th August 2020 for all studies investigating either diabetic or HIV neuropathy and MRI, focusing exclusively on studies investigating symmetrical polyneuropathy. The NIH quality assessment tool for observational and cross-sectional cohort studies was used for risk of bias assessment. Results: The search resulted in 18 papers eligible for review, 18 for diabetic neuropathy and 0 for HIV neuropathy. Risk of bias assessment demonstrated that studies generally lacked explicit sample size justifications, and some may be underpowered. Whilst most studies made efforts to balance groups for confounding variables (age, gender, BMI, disease duration), there was lack of consistencybetween studies. Overall, the literature provides convincing evidence that DPN is associated with larger nerve cross sectional area, T2-weighted hyperintense and hypointense lesions, evidence of nerve oedema on Dixon imaging, decreased fractional anisotropy and increased apparent dif
AU  - Evans,M
AU  - Wade,C
AU  - Hohenschurz-Schmidt,D
AU  - Lally,P
AU  - Ugwudike,A
AU  - Shah,K
AU  - Bangerter,N
AU  - Sharp,D
AU  - Rice,ASC
DO  - 10.3389/fnins.2021.727311
PY  - 2021///
SN  - 1662-453X
TI  - Magnetic resonance imaging as a biomarker in diabetic and HIV-associated peripheral neuropathy: A systematic review-based narrative
T2  - Frontiers in Neuroscience
UR  - http://dx.doi.org/10.3389/fnins.2021.727311
UR  - http://hdl.handle.net/10044/1/91135
VL  - 15
ER  -

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