Imperial College London
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ProfessorDavidSharp

Faculty of Medicine, Department of Brain Sciences

Professor of Neurology
 
 
 
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Contact

 

+44 (0)20 7594 7991david.sharp Website

 
 
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Location

 

UREN.927Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Baker:2022:braincomms/fcac033,
author = {Baker, C and Martin, P and Wilson, M and Ghajari, M and Sharp, D},
doi = {braincomms/fcac033},
journal = {Brain Communications},
title = {The relationship between road traffic collision dynamics and traumatic brain injury pathology},
url = {http://dx.doi.org/10.1093/braincomms/fcac033},
volume = {4},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Road traffic collisions are a major cause of traumatic brain injury. However, the relationship between road traffic collision dynamics and traumatic brain injury risk for different road users is unknown. We investigated 2,065 collisions from Great Britain’s Road Accident In-depth Studies collision database involving 5,374 subjects (2013-20). 595 subjects sustained a traumatic brain injury (20.2% of 2,940 casualties), including 315 moderate-severe and 133 mild-probable. Key pathologies included skull fracture (179, 31.9%), subarachnoid haemorrhage (171, 30.5%), focal brain injury (168, 29.9%) and subdural haematoma (96, 17.1%). These results were extended nationally using  >1,000,000 police-reported collision casualties. Extrapolating  from  the in-depth data we estimate that there are ~20,000 traumatic brain injury casualties (~5,000  moderate-severe) annually on Great Britain’s roads, accounting for severity differences. Detailed  collision  investigation allows vehicle collision dynamics to be understood and the change-in-velocity (known as delta-V) to be estimated for a subset of in-depth collision data. Higher delta-V increased the risk of moderate-severe brain injury for  all road users. The four key pathologies were not observed below 8km/h delta-V for pedestrians/cyclists and 19km/h delta-V for car occupants (higher delta-V threshold for focal injury in both groups). Traumatic brain injury risk depended on road user type, delta-V and impact direction. Accounting for delta-V, pedestrians/cyclists had a 6-times higher likelihood of moderate-severe brain injury than car occupants. Wearing a cycle helmet was protective against overall and mild-to-moderate-severe brain injury, particularly skull fracture and subdural haematoma. Cycle helmet protection was not due to travel or impact speed differences between helmeted and non-helmeted cyclist groups. We additionally examined the influence of delta-V direction. Car occupants exposed to a higher latera
AU  - Baker,C
AU  - Martin,P
AU  - Wilson,M
AU  - Ghajari,M
AU  - Sharp,D
DO  - braincomms/fcac033
PY  - 2022///
SN  - 2632-1297
TI  - The relationship between road traffic collision dynamics and traumatic brain injury pathology
T2  - Brain Communications
UR  - http://dx.doi.org/10.1093/braincomms/fcac033
UR  - https://academic.oup.com/braincomms/article/4/2/fcac033/6527565
UR  - http://hdl.handle.net/10044/1/94461
VL  - 4
ER  -
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